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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | W | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | CC Sabathia | 233 | 2002-2020 | |
| 2 | Justin Verlander# | 202 | 2007-2026 | |
| 3 | Catfish Hunter | 201 | 1965-1976 | |
| 4 | Adam Wainwright | 183 | 2004-2023 | |
| 5 | Clayton Kershaw# | 182 | 2009-2025 | |
| 6 | Max Scherzer# | 176 | 2009-2026 | |
| 7 | Jake Peavy | 175 | 2002-2018 | |
| 8 | Felix Hernandez | 167 | 2005-2021 | |
| 9 | Sandy Koufax | 165 | 1955-1966 | |
| 10 | Josh M. Johnson | 160 | 2006-2017 | |
| 11 | John Lackey | 159 | 2003-2017 | |
| 12 | Smith Smith | 158 | 2002-2017 | |
| 13 | Bartolo Colon | 153 | 1997-2019 | |
| 14 | Cole Hamels | 149 | 2007-2022 | |
| 14 | Jon Lester | 149 | 2007-2021 | |
| 14 | David Price | 149 | 2009-2023 | |
| 17 | Johnny Cueto | 146 | 2010-2023 | |
| 17 | Stephen Strasburg | 146 | 2010-2025 | |
| 19 | Zack Wheeler# | 141 | 2010-2026 | |
| 20 | Lance Lynn# | 138 | 2010-2025 | |
| 20 | Smith Smith | 138 | 2006-2020 | |
| 22 | Larry Dierker | 137 | 1964-1976 | |
| 23 | Charlie Morton# | 136 | 2010-2025 | |
| 24 | Nathan Eovaldi# | 132 | 2012-2026 | |
| 25 | Yu Darvish# | 130 | 2012-2026 | |
| 26 | Jacob Degrom# | 128 | 2012-2026 | |
| 26 | Bob Feller | 128 | 1947-1956 | |
| 28 | Chris Sale# | 127 | 2011-2026 | |
| 29 | Johnny Antonelli | 126 | 1948-1961 | |
| 29 | Gerrit Cole# | 126 | 2012-2026 | |
| 29 | Lance McCullers Jr.# | 126 | 2016-2026 | |
| 29 | Anibal Sanchez | 126 | 2007-2021 | |
| 33 | Matt Cain | 123 | 2006-2019 | |
| 34 | Michael Pineda | 121 | 2011-2023 | |
| 35 | Smith Smith | 119 | 2004-2017 | |
| 36 | Kevin Gausman# | 116 | 2013-2026 | |
| 37 | J.J. Franco | 115 | 1999-2014 | |
| 37 | Scott Kazmir | 115 | 2005-2018 | |
| 39 | Jered Weaver | 112 | 2007-2017 | |
| 40 | Jordan Zimmermann | 111 | 2010-2021 | |
| 41 | James Shields | 110 | 2007-2019 | |
| 42 | Patrick Corbin# | 109 | 2012-2026 | |
| 43 | Jose Quintana# | 108 | 2013-2025 | |
| 44 | Ricky Nolasco | 107 | 2007-2017 | |
| 45 | Edinson Volquez | 106 | 2008-2020 | |
| 46 | Alex Cobb# | 105 | 2012-2025 | |
| 46 | Kyle Gibson# | 105 | 2010-2025 | |
| 46 | Billy O'Dell | 105 | 1954-1967 | |
| 46 | Jameson Taillon# | 105 | 2014-2026 | |
| 50 | Aaron Harang | 104 | 2002-2015 | |
| 51 | Madison Bumgarner | 103 | 2011-2023 | |
| 52 | Clay Buchholz | 102 | 2008-2020 | |
| 52 | Lucas Giolito# | 102 | 2016-2026 | |
| 54 | Gio Gonzalez | 101 | 2010-2022 | |
| 54 | Marcus Stroman# | 101 | 2015-2026 | |
| 56 | Jon Gray# | 100 | 2015-2026 | |
| 56 | Rick Porcello | 100 | 2011-2021 | |
| 56 | Brandon Woodruff# | 100 | 2015-2026 | |
| 59 | Rich Hill# | 99 | 2006-2023 | |
| 59 | Ian Kennedy | 99 | 2010-2022 | |
| 59 | Tyler Mahle# | 99 | 2017-2026 | |
| 59 | Brandon McCarthy | 99 | 2006-2019 | |
| 59 | Ervin Santana | 99 | 2002-2019 | |
| 64 | Max Fried# | 98 | 2018-2026 | |
| 64 | German Marquez# | 98 | 2018-2025 | |
| 66 | Wade Miley# | 97 | 2010-2024 | |
| 66 | Danny Salazar | 97 | 2010-2021 | |
| 68 | Chad Billingsley | 96 | 2007-2015 | |
| 68 | Ubaldo Jimenez | 96 | 2010-2020 | |
| 70 | Brett Anderson | 95 | 2010-2021 | |
| 70 | Brett Myers | 95 | 2003-2014 | |
| 70 | Michael Wacha# | 95 | 2015-2026 | |
| 73 | Phil Hughes | 94 | 2009-2018 | |
| 73 | Jeff Samardzija | 94 | 2010-2020 | |
| 75 | Miles Mikolas# | 93 | 2010-2025 | |
| 75 | Shohei Ohtani# | 93 | 2018-2026 | |
| 75 | Masahiro Tanaka | 93 | 2014-2021 | |
| 78 | Sonny Gray# | 92 | 2012-2026 | |
| 78 | Carlos Rodon# | 92 | 2015-2026 | |
| 78 | Luis Severino# | 92 | 2016-2026 | |
| 81 | Tim Lincecum | 91 | 2009-2018 | |
| 81 | Aaron Nola# | 91 | 2015-2026 | |
| 83 | Tyler Anderson# | 90 | 2012-2026 | |
| 83 | James Happ | 90 | 2009-2022 | |
| 83 | Steve Matz# | 90 | 2010-2026 | |
| 86 | Corey Kluber | 89 | 2011-2023 | |
| 86 | James Paxton# | 89 | 2014-2025 | |
| 86 | Garrett Richards | 89 | 2012-2022 | |
| 89 | Chris Archer | 87 | 2012-2023 | |
| 89 | Julio Teheran | 87 | 2011-2022 | |
| 89 | Chris Young | 87 | 2004-2016 | |
| 92 | Matt Garza | 86 | 2009-2017 | |
| 92 | Andrew Heaney# | 86 | 2018-2026 | |
| 92 | Kyle Hendricks# | 86 | 2016-2024 | |
| 92 | Collin McHugh | 86 | 2010-2024 | |
| 96 | Jake Arrieta | 85 | 2011-2022 | |
| 96 | Rich Harden | 85 | 2004-2013 | |
| 96 | Paul Maholm | 85 | 2006-2015 | |
| 96 | Jake Odorizzi | 85 | 2012-2023 | |
| 96 | Hyun-Jin Ryu | 85 | 2013-2023 |
