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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | W | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | CC Sabathia | 233 | 2002-2020 | |
| 2 | Catfish Hunter | 201 | 1965-1976 | |
| 3 | Justin Verlander# | 197 | 2007-2025 | |
| 4 | Adam Wainwright | 183 | 2004-2023 | |
| 5 | Clayton Kershaw# | 180 | 2009-2025 | |
| 6 | Jake Peavy | 175 | 2002-2018 | |
| 7 | Max Scherzer# | 172 | 2009-2025 | |
| 8 | Felix Hernandez | 167 | 2005-2021 | |
| 9 | Sandy Koufax | 165 | 1955-1966 | |
| 10 | Josh M. Johnson | 160 | 2006-2017 | |
| 11 | John Lackey | 159 | 2003-2017 | |
| 12 | Smith Smith | 158 | 2002-2017 | |
| 13 | Bartolo Colon | 153 | 1997-2019 | |
| 14 | Cole Hamels | 149 | 2007-2022 | |
| 14 | Jon Lester | 149 | 2007-2021 | |
| 14 | David Price | 149 | 2009-2023 | |
| 17 | Johnny Cueto | 146 | 2010-2023 | |
| 18 | Stephen Strasburg# | 144 | 2010-2025 | |
| 19 | Smith Smith | 138 | 2006-2020 | |
| 20 | Larry Dierker | 137 | 1964-1976 | |
| 20 | Lance Lynn# | 137 | 2010-2025 | |
| 20 | Zack Wheeler# | 137 | 2010-2025 | |
| 23 | Charlie Morton# | 134 | 2010-2025 | |
| 24 | Bob Feller | 128 | 1947-1956 | |
| 25 | Johnny Antonelli | 126 | 1948-1961 | |
| 25 | Yu Darvish# | 126 | 2012-2025 | |
| 25 | Anibal Sanchez | 126 | 2007-2021 | |
| 28 | Matt Cain | 123 | 2006-2019 | |
| 28 | Gerrit Cole# | 123 | 2012-2025 | |
| 30 | Nathan Eovaldi# | 122 | 2012-2025 | |
| 31 | Michael Pineda | 121 | 2011-2023 | |
| 32 | Jacob Degrom# | 119 | 2012-2025 | |
| 32 | Lance McCullers Jr.# | 119 | 2016-2025 | |
| 32 | Smith Smith | 119 | 2004-2017 | |
| 35 | J.J. Franco | 115 | 1999-2014 | |
| 35 | Scott Kazmir | 115 | 2005-2018 | |
| 37 | Chris Sale# | 113 | 2011-2025 | |
| 38 | Jered Weaver | 112 | 2007-2017 | |
| 39 | Kevin Gausman# | 111 | 2013-2025 | |
| 39 | Jordan Zimmermann | 111 | 2010-2021 | |
| 41 | James Shields | 110 | 2007-2019 | |
| 42 | Jose Quintana# | 108 | 2013-2025 | |
| 43 | Ricky Nolasco | 107 | 2007-2017 | |
| 44 | Edinson Volquez | 106 | 2008-2020 | |
| 45 | Kyle Gibson# | 105 | 2010-2024 | |
| 45 | Billy O'Dell | 105 | 1954-1967 | |
| 47 | Aaron Harang | 104 | 2002-2015 | |
| 48 | Madison Bumgarner | 103 | 2011-2023 | |
| 49 | Clay Buchholz | 102 | 2008-2020 | |
| 49 | Alex Cobb# | 102 | 2012-2025 | |
| 51 | Gio Gonzalez | 101 | 2010-2022 | |
| 52 | Rick Porcello | 100 | 2011-2021 | |
| 52 | Jameson Taillon# | 100 | 2014-2025 | |
| 54 | Rich Hill# | 99 | 2006-2023 | |
| 54 | Ian Kennedy | 99 | 2010-2022 | |
| 54 | Brandon McCarthy | 99 | 2006-2019 | |
| 54 | Ervin Santana | 99 | 2002-2019 | |
| 58 | Lucas Giolito# | 97 | 2016-2025 | |
| 58 | German Marquez# | 97 | 2018-2025 | |
| 58 | Wade Miley# | 97 | 2010-2024 | |
| 58 | Danny Salazar | 97 | 2010-2021 | |
| 62 | Chad Billingsley | 96 | 2007-2015 | |
| 62 | Jon Gray# | 96 | 2015-2025 | |
| 62 | Ubaldo Jimenez | 96 | 2010-2020 | |
| 65 | Brett Anderson | 95 | 2010-2021 | |
| 65 | Brett Myers | 95 | 2003-2014 | |
| 65 | Marcus Stroman# | 95 | 2015-2025 | |
| 68 | Phil Hughes | 94 | 2009-2018 | |
| 68 | Jeff Samardzija | 94 | 2010-2020 | |
| 70 | Masahiro Tanaka | 93 | 2014-2021 | |
| 71 | Max Fried# | 92 | 2018-2025 | |
| 71 | Michael Wacha# | 92 | 2015-2025 | |
| 73 | Tim Lincecum | 91 | 2009-2018 | |
| 73 | Tyler Mahle# | 91 | 2017-2025 | |
| 73 | Miles Mikolas# | 91 | 2010-2025 | |
| 76 | James Happ | 90 | 2009-2022 | |
| 77 | Sonny Gray# | 89 | 2012-2025 | |
| 77 | Corey Kluber | 89 | 2011-2023 | |
| 77 | James Paxton# | 89 | 2014-2025 | |
| 77 | Garrett Richards | 89 | 2012-2022 | |
| 81 | Luis Severino# | 88 | 2016-2025 | |
| 81 | Brandon Woodruff# | 88 | 2015-2025 | |
| 83 | Chris Archer | 87 | 2012-2023 | |
| 83 | Carlos Rodon# | 87 | 2015-2025 | |
| 83 | Julio Teheran | 87 | 2011-2022 | |
| 83 | Chris Young | 87 | 2004-2016 | |
| 87 | Matt Garza | 86 | 2009-2017 | |
| 87 | Kyle Hendricks# | 86 | 2016-2024 | |
| 87 | Collin McHugh | 86 | 2010-2024 | |
| 87 | Shohei Ohtani# | 86 | 2018-2025 | |
| 91 | Jake Arrieta | 85 | 2011-2022 | |
| 91 | Rich Harden | 85 | 2004-2013 | |
| 91 | Paul Maholm | 85 | 2006-2015 | |
| 91 | Aaron Nola# | 85 | 2015-2025 | |
| 91 | Jake Odorizzi | 85 | 2012-2023 | |
| 91 | Hyun-Jin Ryu | 85 | 2013-2023 | |
| 97 | John Danks | 84 | 2008-2018 | |
| 97 | Matt Harvey | 84 | 2014-2021 | |
| 99 | Tyler Anderson# | 83 | 2012-2025 | |
| 99 | Carlos Carrasco | 83 | 2010-2023 |
