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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | L | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Smith Smith | 177 | 2002-2017 | |
| 2 | Bartolo Colon | 155 | 1997-2019 | |
| 2 | Aaron Harang | 155 | 2002-2015 | |
| 4 | Adam Wainwright | 154 | 2004-2023 | |
| 5 | CC Sabathia | 151 | 2002-2020 | |
| 6 | J.J. Franco | 146 | 1999-2014 | |
| 7 | Smith Smith | 145 | 2006-2020 | |
| 8 | Catfish Hunter | 142 | 1965-1976 | |
| 9 | Felix Hernandez | 141 | 2005-2021 | |
| 9 | John Lackey | 141 | 2003-2017 | |
| 11 | Clayton Kershaw# | 136 | 2009-2025 | |
| 12 | Charlie Morton# | 135 | 2010-2025 | |
| 13 | Lance Lynn# | 130 | 2010-2025 | |
| 13 | Jordan Zimmermann | 130 | 2010-2021 | |
| 15 | Jake Arrieta | 128 | 2011-2022 | |
| 15 | Cole Hamels | 128 | 2007-2022 | |
| 15 | Brandon McCarthy | 128 | 2006-2019 | |
| 18 | Scott Kazmir | 127 | 2005-2018 | |
| 19 | Jon Lester | 126 | 2007-2021 | |
| 20 | Jake Peavy | 125 | 2002-2018 | |
| 21 | Michael Pineda | 123 | 2011-2023 | |
| 22 | Alex Cobb# | 122 | 2012-2025 | |
| 22 | Kevin Gausman# | 122 | 2013-2025 | |
| 22 | Rich Hill# | 122 | 2006-2023 | |
| 25 | Johnny Cueto | 121 | 2010-2023 | |
| 26 | Zack Wheeler# | 119 | 2010-2025 | |
| 27 | John Danks | 118 | 2008-2018 | |
| 27 | Gavin Floyd | 118 | 2005-2017 | |
| 27 | Max Scherzer# | 118 | 2009-2025 | |
| 30 | Larry Dierker | 117 | 1964-1976 | |
| 31 | James Shields | 116 | 2007-2019 | |
| 32 | Anibal Sanchez | 115 | 2007-2021 | |
| 33 | Stephen Strasburg# | 114 | 2010-2025 | |
| 34 | Justin Verlander# | 113 | 2007-2025 | |
| 35 | Brett Anderson | 112 | 2010-2021 | |
| 35 | Jose Quintana# | 112 | 2013-2025 | |
| 37 | Johnny Antonelli | 110 | 1948-1961 | |
| 37 | Michael Wacha# | 110 | 2015-2025 | |
| 39 | Danny Duffy | 109 | 2012-2022 | |
| 40 | Brett Myers | 107 | 2003-2014 | |
| 41 | Jon Gray# | 105 | 2015-2025 | |
| 41 | Edinson Volquez | 105 | 2008-2020 | |
| 43 | Madison Bumgarner | 104 | 2011-2023 | |
| 43 | Julio Teheran | 104 | 2011-2022 | |
| 45 | Clay Buchholz | 103 | 2008-2020 | |
| 45 | Dylan Bundy | 103 | 2012-2023 | |
| 45 | Gio Gonzalez | 103 | 2010-2022 | |
| 45 | Jered Weaver | 103 | 2007-2017 | |
| 49 | Matt Cain | 102 | 2006-2019 | |
| 49 | Jameson Taillon# | 102 | 2014-2025 | |
| 51 | Billy O'Dell | 100 | 1954-1967 | |
| 52 | Homer Bailey | 99 | 2009-2020 | |
| 52 | James Happ | 99 | 2009-2022 | |
| 52 | Kyle Hendricks# | 99 | 2016-2024 | |
| 52 | Matt Moore# | 99 | 2012-2025 | |
| 52 | Chris Sale# | 99 | 2011-2025 | |
| 52 | Chris Young | 99 | 2004-2016 | |
| 58 | Sonny Gray# | 98 | 2012-2025 | |
| 58 | Ervin Santana | 98 | 2002-2019 | |
| 60 | Smith Smith | 97 | 2004-2017 | |
| 61 | Josh M. Johnson | 95 | 2006-2017 | |
| 61 | Rick Porcello | 95 | 2011-2021 | |
| 63 | Gerrit Cole# | 93 | 2012-2025 | |
| 64 | Garrett Richards | 92 | 2012-2022 | |
| 64 | Smith Smith | 92 | 2003-2017 | |
| 64 | Taijuan Walker# | 92 | 2012-2025 | |
| 67 | Ryan Madson | 91 | 2003-2019 | |
| 67 | Mike Minor | 91 | 2010-2023 | |
| 69 | Carlos Carrasco | 90 | 2010-2023 | |
| 69 | Nathan Eovaldi# | 90 | 2012-2025 | |
| 69 | Bob Feller | 90 | 1947-1956 | |
| 69 | Paul Maholm | 90 | 2006-2015 | |
| 69 | Miles Mikolas# | 90 | 2010-2025 | |
| 69 | Ricky Nolasco | 90 | 2007-2017 | |
| 75 | Joe Blanton | 88 | 2006-2017 | |
| 75 | Wade Miley# | 88 | 2010-2024 | |
| 75 | Masahiro Tanaka | 88 | 2014-2021 | |
| 78 | Sandy Koufax | 87 | 1955-1966 | |
| 79 | Tyler Mahle# | 86 | 2017-2025 | |
| 79 | Mike Pelfrey | 86 | 2008-2017 | |
| 79 | Hyun-Jin Ryu | 86 | 2013-2023 | |
| 82 | Jason Hammel | 85 | 2008-2018 | |
| 82 | Jordan Montgomery# | 85 | 2015-2025 | |
| 84 | Phil Hughes | 84 | 2009-2018 | |
| 84 | Smith Smith | 84 | 2008-2017 | |
| 84 | Josh Tomlin | 84 | 2011-2022 | |
| 87 | Jeff Samardzija | 83 | 2010-2020 | |
| 88 | Chris Bassitt# | 82 | 2016-2025 | |
| 88 | Kyle Gibson# | 82 | 2010-2025 | |
| 88 | German Marquez# | 82 | 2018-2025 | |
| 91 | Tyler Anderson# | 81 | 2012-2025 | |
| 91 | Yu Darvish# | 81 | 2012-2025 | |
| 91 | Matt Garza | 81 | 2009-2017 | |
| 91 | Mike Leake | 81 | 2010-2020 | |
| 91 | Tyson Ross | 81 | 2012-2019 | |
| 96 | Wade Davis | 80 | 2009-2020 | |
| 96 | Kenta Maeda# | 80 | 2016-2025 | |
| 96 | James Paxton# | 80 | 2014-2025 | |
| 96 | Martin Perez# | 80 | 2010-2025 | |
| 96 | David Price | 80 | 2009-2023 |
