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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | SV | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Craig Kimbrel# | 423 | 2011-2025 | |
| 2 | Francisco Rodriguez | 407 | 2003-2018 | |
| 3 | Kenley Jansen# | 334 | 2012-2025 | |
| 4 | Joe Nathan | 307 | 2000-2016 | |
| 5 | Huston Street | 286 | 2005-2016 | |
| 6 | Jonathan Papelbon | 278 | 2006-2017 | |
| 7 | Aroldis Chapman# | 263 | 2011-2025 | |
| 8 | Rafael Soriano | 219 | 2003-2015 | |
| 9 | Edwin Diaz# | 209 | 2017-2025 | |
| 10 | Josh Hader# | 207 | 2017-2025 | |
| 11 | David Robertson# | 201 | 2010-2025 | |
| 12 | Mark Melancon | 197 | 2010-2023 | |
| 13 | Jeurys Familia | 174 | 2010-2022 | |
| 14 | Luke Gregerson | 169 | 2010-2019 | |
| 15 | Ryan Madson | 166 | 2003-2019 | |
| 16 | Jason Grilli | 164 | 2001-2017 | |
| 17 | Joakim Soria | 161 | 2007-2020 | |
| 18 | Glen Perkins | 155 | 2009-2018 | |
| 18 | Sergio Romo | 155 | 2010-2021 | |
| 20 | Jonathan Broxton | 153 | 2007-2017 | |
| 21 | Raisel Iglesias# | 145 | 2016-2025 | |
| 22 | Jordan Hicks# | 136 | 2019-2025 | |
| 23 | Taylor Rogers# | 131 | 2018-2025 | |
| 24 | Trevor Rosenthal | 129 | 2010-2023 | |
| 25 | Wade Davis | 126 | 2009-2020 | |
| 26 | Brian Wilson | 125 | 2009-2014 | |
| 27 | Greg Holland | 120 | 2012-2020 | |
| 27 | Devin Williams# | 120 | 2020-2025 | |
| 29 | Hansel Robles | 117 | 2017-2023 | |
| 30 | Smith Smith | 114 | 2005-2014 | |
| 31 | Cody Allen | 112 | 2015-2020 | |
| 32 | Blake Treinen# | 109 | 2012-2025 | |
| 33 | Joe Smith | 107 | 2008-2022 | |
| 34 | Bobby Parnell | 106 | 2009-2016 | |
| 35 | Grant Balfour | 102 | 2005-2014 | |
| 35 | Alex Colome | 102 | 2010-2022 | |
| 35 | Chad Green# | 102 | 2018-2025 | |
| 35 | Hector Rondon | 102 | 2010-2021 | |
| 39 | Addison Reed | 101 | 2012-2020 | |
| 40 | Tanner Scott# | 97 | 2020-2025 | |
| 41 | Sean Doolittle | 92 | 2011-2022 | |
| 41 | Giovanny Gallegos# | 92 | 2018-2025 | |
| 41 | Darren O'Day | 92 | 2010-2022 | |
| 44 | James Karinchak# | 91 | 2020-2025 | |
| 45 | Tyler Clippard | 90 | 2007-2019 | |
| 45 | Kyuji Fujikawa | 90 | 2013-2016 | |
| 47 | Carlos Marmol | 89 | 2008-2015 | |
| 48 | Archie Bradley | 88 | 2012-2022 | |
| 49 | Santiago Casilla | 87 | 2005-2017 | |
| 50 | Liam Hendriks# | 86 | 2012-2025 | |
| 50 | Jake McGee | 86 | 2010-2022 | |
| 52 | David Aardsma | 85 | 2007-2013 | |
| 53 | Felix Bautista# | 84 | 2023-2025 | |
| 53 | Will Harris | 84 | 2010-2022 | |
| 53 | Smith Smith | 84 | 2005-2015 | |
| 56 | Ryan Pressly# | 83 | 2016-2025 | |
| 57 | Jordan Walden | 82 | 2012-2016 | |
| 58 | Tony Watson | 79 | 2011-2021 | |
| 59 | Austin Adams# | 78 | 2018-2025 | |
| 59 | Nick Anderson# | 78 | 2020-2025 | |
| 59 | Steve Cishek | 78 | 2012-2021 | |
| 62 | Andrew Bailey | 77 | 2010-2016 | |
| 63 | Andres Munoz# | 76 | 2021-2025 | |
| 64 | Joel Peralta | 75 | 2005-2016 | |
| 65 | Dellin Betances | 72 | 2011-2021 | |
| 65 | Brad Brach | 72 | 2014-2020 | |
| 67 | John Axford | 71 | 2010-2017 | |
| 68 | Smith Smith | 70 | 2002-2018 | |
| 69 | Scott Barlow# | 69 | 2020-2025 | |
| 70 | Bryan Abreu# | 66 | 2022-2025 | |
| 70 | Seranthony Dominguez# | 66 | 2019-2025 | |
| 72 | Tommy Kahnle# | 65 | 2018-2025 | |
| 72 | Hector Neris# | 65 | 2019-2025 | |
| 74 | Carlos Estevez# | 63 | 2020-2025 | |
| 74 | Peter Fairbanks# | 63 | 2020-2025 | |
| 74 | Smith Smith | 63 | 2001-2013 | |
| 77 | Brusdar Graterol# | 62 | 2022-2025 | |
| 77 | Fernando Rodney | 62 | 2005-2018 | |
| 77 | Craig Stammen | 62 | 2007-2023 | |
| 77 | Koji Uehara | 62 | 2009-2018 | |
| 81 | Jalen Beeks# | 59 | 2015-2025 | |
| 82 | Jason Adam# | 55 | 2014-2025 | |
| 83 | Diego Castillo# | 54 | 2020-2023 | |
| 84 | Tyler Rogers# | 53 | 2020-2025 | |
| 85 | Aaron Barrett | 51 | 2012-2017 | |
| 86 | Brandon Kintzler | 50 | 2012-2020 | |
| 86 | Vidal Nuno | 50 | 2010-2019 | |
| 88 | Jose Alvarado# | 49 | 2018-2025 | |
| 88 | Matt Moore# | 49 | 2012-2025 | |
| 88 | Kirby Yates# | 49 | 2018-2025 | |
| 91 | Aaron Loup | 48 | 2010-2023 | |
| 91 | Billy O'Dell | 48 | 1954-1967 | |
| 93 | Jesse Crain | 47 | 2006-2015 | |
| 93 | David Hernandez | 47 | 2010-2019 | |
| 95 | Adam Ottavino# | 46 | 2010-2024 | |
| 95 | Fernando Salas | 46 | 2012-2017 | |
| 95 | Drew Storen | 46 | 2011-2018 | |
| 95 | C.J. Wilson | 46 | 2008-2017 | |
| 99 | Darin Downs | 45 | 2010-2015 | |
| 99 | Ian Hamilton# | 45 | 2020-2025 |
