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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | GS | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | CC Sabathia | 498 | 2002-2020 | |
| 2 | Clayton Kershaw# | 456 | 2009-2025 | |
| 3 | Justin Verlander# | 435 | 2007-2026 | |
| 3 | Adam Wainwright | 435 | 2004-2023 | |
| 5 | Max Scherzer# | 429 | 2009-2026 | |
| 6 | Smith Smith | 427 | 2002-2017 | |
| 7 | Bartolo Colon | 417 | 1997-2019 | |
| 8 | Felix Hernandez | 415 | 2005-2021 | |
| 8 | Catfish Hunter | 415 | 1965-1976 | |
| 10 | Smith Smith | 411 | 2006-2020 | |
| 11 | Cole Hamels | 410 | 2007-2022 | |
| 12 | Lance Lynn# | 408 | 2010-2025 | |
| 13 | John Lackey | 399 | 2003-2017 | |
| 14 | Jake Peavy | 384 | 2002-2018 | |
| 15 | Charlie Morton# | 381 | 2010-2025 | |
| 16 | Johnny Cueto | 378 | 2010-2023 | |
| 17 | Zack Wheeler# | 375 | 2010-2026 | |
| 18 | Jon Lester | 373 | 2007-2021 | |
| 19 | Aaron Harang | 365 | 2002-2015 | |
| 20 | Josh M. Johnson | 361 | 2006-2017 | |
| 21 | Stephen Strasburg | 356 | 2010-2025 | |
| 22 | Scott Kazmir | 350 | 2005-2018 | |
| 23 | Michael Pineda | 348 | 2011-2023 | |
| 24 | J.J. Franco | 345 | 1999-2014 | |
| 25 | Kevin Gausman# | 342 | 2013-2026 | |
| 26 | Chris Sale# | 341 | 2011-2026 | |
| 27 | Rich Hill# | 339 | 2006-2023 | |
| 28 | Anibal Sanchez | 333 | 2007-2021 | |
| 29 | Patrick Corbin# | 330 | 2012-2026 | |
| 30 | Jose Quintana# | 326 | 2013-2025 | |
| 31 | Gerrit Cole# | 325 | 2012-2026 | |
| 32 | Alex Cobb# | 323 | 2012-2025 | |
| 32 | Yu Darvish# | 323 | 2012-2026 | |
| 32 | Nathan Eovaldi# | 323 | 2012-2026 | |
| 35 | Larry Dierker | 320 | 1964-1976 | |
| 36 | Jordan Zimmermann | 316 | 2010-2021 | |
| 37 | Sandy Koufax | 314 | 1955-1966 | |
| 37 | James Shields | 314 | 2007-2019 | |
| 39 | Jake Arrieta | 313 | 2011-2022 | |
| 40 | Jon Gray# | 311 | 2015-2026 | |
| 41 | Smith Smith | 309 | 2004-2017 | |
| 42 | Matt Cain | 308 | 2006-2019 | |
| 43 | David Price | 307 | 2009-2023 | |
| 44 | Lance McCullers Jr.# | 304 | 2016-2026 | |
| 45 | Brandon McCarthy | 301 | 2006-2019 | |
| 46 | Jameson Taillon# | 299 | 2014-2026 | |
| 46 | Michael Wacha# | 299 | 2015-2026 | |
| 48 | Jered Weaver | 297 | 2007-2017 | |
| 49 | James Happ | 292 | 2009-2022 | |
| 50 | Gio Gonzalez | 290 | 2010-2022 | |
| 51 | Sonny Gray# | 281 | 2012-2026 | |
| 51 | Brett Myers | 281 | 2003-2014 | |
| 53 | Jacob Degrom# | 276 | 2012-2026 | |
| 53 | Ricky Nolasco | 276 | 2007-2017 | |
| 55 | Brett Anderson | 274 | 2010-2021 | |
| 55 | Clay Buchholz | 274 | 2008-2020 | |
| 57 | Edinson Volquez | 273 | 2008-2020 | |
| 58 | Madison Bumgarner | 271 | 2011-2023 | |
| 58 | Rick Porcello | 271 | 2011-2021 | |
| 60 | Johnny Antonelli | 268 | 1948-1961 | |
| 61 | James Paxton# | 266 | 2014-2025 | |
| 61 | Ervin Santana | 266 | 2002-2019 | |
| 63 | John Danks | 264 | 2008-2018 | |
| 64 | Carlos Carrasco | 263 | 2010-2023 | |
| 65 | Julio Teheran | 261 | 2011-2022 | |
| 66 | Jeff Samardzija | 260 | 2010-2020 | |
| 67 | Mike Minor | 259 | 2010-2023 | |
| 68 | Bob Feller | 258 | 1947-1956 | |
| 68 | Tyler Mahle# | 258 | 2017-2026 | |
| 70 | Max Fried# | 256 | 2018-2026 | |
| 71 | Gavin Floyd | 255 | 2005-2017 | |
| 72 | Tyler Anderson# | 253 | 2012-2026 | |
| 73 | Wade Miley# | 252 | 2010-2024 | |
| 74 | Kyle Gibson# | 251 | 2010-2025 | |
| 75 | Lucas Giolito# | 250 | 2016-2026 | |
| 75 | Hyun-Jin Ryu | 250 | 2013-2023 | |
| 75 | Marcus Stroman# | 250 | 2015-2026 | |
| 78 | Chris Archer | 249 | 2012-2023 | |
| 79 | Kyle Hendricks# | 248 | 2016-2024 | |
| 79 | Chris Young | 248 | 2004-2016 | |
| 81 | Danny Salazar | 247 | 2010-2021 | |
| 81 | Taijuan Walker# | 247 | 2012-2026 | |
| 83 | Danny Duffy | 246 | 2012-2022 | |
| 83 | Masahiro Tanaka | 246 | 2014-2021 | |
| 85 | Phil Hughes | 244 | 2009-2018 | |
| 85 | Aaron Nola# | 244 | 2015-2026 | |
| 87 | Homer Bailey | 240 | 2009-2020 | |
| 87 | Miles Mikolas# | 240 | 2010-2025 | |
| 89 | Carlos Rodon# | 239 | 2015-2026 | |
| 89 | Brandon Woodruff# | 239 | 2015-2026 | |
| 91 | Chris Bassitt# | 237 | 2016-2026 | |
| 91 | German Marquez# | 237 | 2018-2025 | |
| 93 | Matt Moore# | 236 | 2012-2025 | |
| 93 | Garrett Richards | 236 | 2012-2022 | |
| 95 | Luis Severino# | 235 | 2016-2026 | |
| 96 | Kenta Maeda# | 234 | 2016-2025 | |
| 96 | Jordan Montgomery# | 234 | 2015-2026 | |
| 98 | Dylan Bundy | 233 | 2012-2023 | |
| 99 | Zach Eflin# | 231 | 2018-2026 | |
| 99 | Ian Kennedy | 231 | 2010-2022 |
