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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | GS | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | CC Sabathia | 498 | 2002-2020 | |
| 2 | Clayton Kershaw# | 450 | 2009-2025 | |
| 3 | Adam Wainwright | 435 | 2004-2023 | |
| 4 | Justin Verlander# | 429 | 2007-2025 | |
| 5 | Smith Smith | 427 | 2002-2017 | |
| 6 | Bartolo Colon | 417 | 1997-2019 | |
| 6 | Max Scherzer# | 417 | 2009-2025 | |
| 8 | Felix Hernandez | 415 | 2005-2021 | |
| 8 | Catfish Hunter | 415 | 1965-1976 | |
| 10 | Smith Smith | 411 | 2006-2020 | |
| 11 | Cole Hamels | 410 | 2007-2022 | |
| 12 | Lance Lynn# | 408 | 2010-2025 | |
| 13 | John Lackey | 399 | 2003-2017 | |
| 14 | Jake Peavy | 384 | 2002-2018 | |
| 15 | Johnny Cueto | 378 | 2010-2023 | |
| 16 | Jon Lester | 373 | 2007-2021 | |
| 16 | Charlie Morton# | 373 | 2010-2025 | |
| 18 | Aaron Harang | 365 | 2002-2015 | |
| 19 | Josh M. Johnson | 361 | 2006-2017 | |
| 20 | Zack Wheeler# | 360 | 2010-2025 | |
| 21 | Scott Kazmir | 350 | 2005-2018 | |
| 22 | Michael Pineda | 348 | 2011-2023 | |
| 22 | Stephen Strasburg# | 348 | 2010-2025 | |
| 24 | J.J. Franco | 345 | 1999-2014 | |
| 25 | Rich Hill# | 339 | 2006-2023 | |
| 26 | Anibal Sanchez | 333 | 2007-2021 | |
| 27 | Kevin Gausman# | 327 | 2013-2025 | |
| 27 | Chris Sale# | 327 | 2011-2025 | |
| 29 | Jose Quintana# | 325 | 2013-2025 | |
| 30 | Larry Dierker | 320 | 1964-1976 | |
| 31 | Jordan Zimmermann | 316 | 2010-2021 | |
| 32 | Alex Cobb# | 315 | 2012-2025 | |
| 33 | Sandy Koufax | 314 | 1955-1966 | |
| 33 | James Shields | 314 | 2007-2019 | |
| 35 | Jake Arrieta | 313 | 2011-2022 | |
| 36 | Yu Darvish# | 311 | 2012-2025 | |
| 37 | Gerrit Cole# | 310 | 2012-2025 | |
| 38 | Nathan Eovaldi# | 309 | 2012-2025 | |
| 38 | Smith Smith | 309 | 2004-2017 | |
| 40 | Matt Cain | 308 | 2006-2019 | |
| 41 | David Price | 307 | 2009-2023 | |
| 42 | Brandon McCarthy | 301 | 2006-2019 | |
| 43 | Jon Gray# | 299 | 2015-2025 | |
| 44 | Jered Weaver | 297 | 2007-2017 | |
| 45 | James Happ | 292 | 2009-2022 | |
| 46 | Gio Gonzalez | 290 | 2010-2022 | |
| 46 | Michael Wacha# | 290 | 2015-2025 | |
| 48 | Lance McCullers Jr.# | 289 | 2016-2025 | |
| 49 | Jameson Taillon# | 285 | 2014-2025 | |
| 50 | Brett Myers | 281 | 2003-2014 | |
| 51 | Ricky Nolasco | 276 | 2007-2017 | |
| 52 | Brett Anderson | 274 | 2010-2021 | |
| 52 | Clay Buchholz | 274 | 2008-2020 | |
| 54 | Edinson Volquez | 273 | 2008-2020 | |
| 55 | Madison Bumgarner | 271 | 2011-2023 | |
| 55 | Rick Porcello | 271 | 2011-2021 | |
| 57 | Johnny Antonelli | 268 | 1948-1961 | |
| 58 | Sonny Gray# | 266 | 2012-2025 | |
| 58 | Ervin Santana | 266 | 2002-2019 | |
| 60 | John Danks | 264 | 2008-2018 | |
| 61 | Carlos Carrasco | 263 | 2010-2023 | |
| 62 | Jacob Degrom# | 261 | 2012-2025 | |
| 62 | Julio Teheran | 261 | 2011-2022 | |
| 64 | Jeff Samardzija | 260 | 2010-2020 | |
| 65 | Mike Minor | 259 | 2010-2023 | |
| 65 | James Paxton# | 259 | 2014-2025 | |
| 67 | Bob Feller | 258 | 1947-1956 | |
| 68 | Gavin Floyd | 255 | 2005-2017 | |
| 69 | Wade Miley# | 252 | 2010-2024 | |
| 70 | Hyun-Jin Ryu | 250 | 2013-2023 | |
| 71 | Chris Archer | 249 | 2012-2023 | |
| 72 | Kyle Gibson# | 248 | 2010-2024 | |
| 72 | Kyle Hendricks# | 248 | 2016-2024 | |
| 72 | Chris Young | 248 | 2004-2016 | |
| 75 | Danny Salazar | 247 | 2010-2021 | |
| 76 | Danny Duffy | 246 | 2012-2022 | |
| 76 | Masahiro Tanaka | 246 | 2014-2021 | |
| 78 | Tyler Anderson# | 245 | 2012-2025 | |
| 79 | Phil Hughes | 244 | 2009-2018 | |
| 79 | Tyler Mahle# | 244 | 2017-2025 | |
| 81 | Marcus Stroman# | 243 | 2015-2025 | |
| 82 | Max Fried# | 242 | 2018-2025 | |
| 83 | Homer Bailey | 240 | 2009-2020 | |
| 84 | Taijuan Walker# | 239 | 2012-2025 | |
| 85 | German Marquez# | 237 | 2018-2025 | |
| 86 | Lucas Giolito# | 236 | 2016-2025 | |
| 86 | Matt Moore# | 236 | 2012-2025 | |
| 86 | Garrett Richards | 236 | 2012-2022 | |
| 89 | Dylan Bundy | 233 | 2012-2023 | |
| 89 | Miles Mikolas# | 233 | 2010-2025 | |
| 91 | Ian Kennedy | 231 | 2010-2022 | |
| 92 | Matt Harvey | 230 | 2014-2021 | |
| 92 | Jake Odorizzi | 230 | 2012-2023 | |
| 94 | Chris Bassitt# | 229 | 2016-2025 | |
| 94 | Aaron Nola# | 229 | 2015-2025 | |
| 94 | Luis Severino# | 229 | 2016-2025 | |
| 97 | Matt Garza | 227 | 2009-2017 | |
| 97 | Kenta Maeda# | 227 | 2016-2025 | |
| 99 | Corey Kluber | 225 | 2011-2023 | |
| 99 | Paul Maholm | 225 | 2006-2015 |
