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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | SHO | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Catfish Hunter | 40 | 1965-1976 | |
| 1 | Sandy Koufax | 40 | 1955-1966 | |
| 3 | Johnny Antonelli | 25 | 1948-1961 | |
| 3 | Larry Dierker | 25 | 1964-1976 | |
| 5 | Bob Feller | 17 | 1947-1956 | |
| 5 | Clayton Kershaw# | 17 | 2009-2025 | |
| 7 | Billy O'Dell | 13 | 1954-1967 | |
| 8 | Jon Lester | 11 | 2007-2021 | |
| 8 | Smith Smith | 11 | 2002-2017 | |
| 10 | Bartolo Colon | 10 | 1997-2019 | |
| 10 | CC Sabathia | 10 | 2002-2020 | |
| 12 | Corey Kluber | 9 | 2011-2023 | |
| 13 | Felix Hernandez | 8 | 2005-2021 | |
| 13 | John Lackey | 8 | 2003-2017 | |
| 13 | Masahiro Tanaka | 8 | 2014-2021 | |
| 16 | Johnny Kucks | 7 | 1955-1960 | |
| 16 | Rick Porcello | 7 | 2011-2021 | |
| 16 | Adam Wainwright | 7 | 2004-2023 | |
| 19 | Madison Bumgarner | 6 | 2011-2023 | |
| 19 | J.J. Franco | 6 | 1999-2014 | |
| 19 | Jon Gray# | 6 | 2015-2025 | |
| 19 | David Price | 6 | 2009-2023 | |
| 19 | Bill Stafford | 6 | 1960-1967 | |
| 24 | Yovani Gallardo | 5 | 2008-2018 | |
| 24 | Cole Hamels | 5 | 2007-2022 | |
| 24 | Andrew Heaney# | 5 | 2018-2025 | |
| 24 | Phil Hughes | 5 | 2009-2018 | |
| 24 | Charlie Morton# | 5 | 2010-2025 | |
| 24 | Jake Peavy | 5 | 2002-2018 | |
| 24 | Michael Pineda | 5 | 2011-2023 | |
| 24 | Danny Salazar | 5 | 2010-2021 | |
| 24 | Anibal Sanchez | 5 | 2007-2021 | |
| 24 | Max Scherzer# | 5 | 2009-2025 | |
| 24 | Charlie Shirek | 5 | 2010-2011 | |
| 35 | Tyler Anderson# | 4 | 2012-2025 | |
| 35 | Shane Bieber# | 4 | 2020-2025 | |
| 35 | Gerrit Cole# | 4 | 2012-2025 | |
| 35 | Yu Darvish# | 4 | 2012-2025 | |
| 35 | Rich Harden | 4 | 2004-2013 | |
| 35 | Paul Maholm | 4 | 2006-2015 | |
| 35 | Carlos Martinez | 4 | 2016-2022 | |
| 35 | Wade Miley# | 4 | 2010-2024 | |
| 35 | Jordan Montgomery# | 4 | 2015-2025 | |
| 35 | Robbie Ray# | 4 | 2017-2025 | |
| 35 | Chris Sale# | 4 | 2011-2024 | |
| 35 | Jeff Samardzija | 4 | 2010-2020 | |
| 35 | Smith Smith | 4 | 2003-2018 | |
| 35 | Blake Snell# | 4 | 2012-2025 | |
| 35 | Stephen Strasburg# | 4 | 2010-2025 | |
| 35 | Marcus Stroman# | 4 | 2015-2024 | |
| 35 | Edinson Volquez | 4 | 2008-2020 | |
| 35 | Zack Wheeler# | 4 | 2010-2025 | |
| 35 | Jordan Zimmermann | 4 | 2010-2021 | |
| 54 | Matt Andriese | 3 | 2012-2023 | |
| 54 | Homer Bailey | 3 | 2009-2020 | |
| 54 | Scott Baker | 3 | 2006-2014 | |
| 54 | Chad Billingsley | 3 | 2007-2015 | |
| 54 | Michael Blazek | 3 | 2010-2017 | |
| 54 | Richard Bleier | 3 | 2010-2023 | |
| 54 | Matt Cain | 3 | 2006-2019 | |
| 54 | Luis Castillo# | 3 | 2020-2025 | |
| 54 | Jhoulys Chacin | 3 | 2010-2020 | |
| 54 | Jacob Degrom# | 3 | 2012-2025 | |
| 54 | Brian Duensing | 3 | 2009-2018 | |
| 54 | Nathan Eovaldi# | 3 | 2012-2025 | |
| 54 | Doug Fister | 3 | 2011-2018 | |
| 54 | Sonny Gray# | 3 | 2012-2025 | |
| 54 | Matt Harrison | 3 | 2007-2015 | |
| 54 | Matt Harvey | 3 | 2014-2021 | |
| 54 | Kyle Hendricks# | 3 | 2016-2024 | |
| 54 | Luke Hochevar | 3 | 2010-2018 | |
| 54 | Drew Hutchison# | 3 | 2010-2019 | |
| 54 | Scott Kazmir | 3 | 2005-2018 | |
| 54 | Ian Kennedy | 3 | 2010-2022 | |
| 54 | Lance Lynn# | 3 | 2010-2025 | |
| 54 | Jeff Manship | 3 | 2010-2011 | |
| 54 | Collin McHugh | 3 | 2010-2024 | |
| 54 | Miles Mikolas# | 3 | 2010-2025 | |
| 54 | Matt Moore# | 3 | 2012-2025 | |
| 54 | Oliver Perez | 3 | 2003-2022 | |
| 54 | Jose Quintana# | 3 | 2013-2025 | |
| 54 | Carlos Rodon# | 3 | 2015-2025 | |
| 54 | Hyun-Jin Ryu | 3 | 2013-2023 | |
| 54 | Ervin Santana | 3 | 2002-2019 | |
| 54 | James Shields | 3 | 2007-2019 | |
| 54 | Matt Shoemaker | 3 | 2015-2021 | |
| 54 | Smith Smith | 3 | 2004-2017 | |
| 54 | Jameson Taillon# | 3 | 2014-2025 | |
| 54 | Julio Teheran | 3 | 2011-2022 | |
| 54 | Justin Verlander# | 3 | 2007-2025 | |
| 54 | Red Witt | 3 | 1957-1962 | |
| 92 | Brett Anderson | 2 | 2010-2021 | |
| 92 | Cody Anderson | 2 | 2012-2017 | |
| 92 | Chris Archer | 2 | 2012-2023 | |
| 92 | Mitchell Atkins | 2 | 2010-2012 | |
| 92 | Jose Berrios# | 2 | 2016-2025 | |
| 92 | Joe Blanton | 2 | 2006-2017 | |
| 92 | Clay Buchholz | 2 | 2008-2020 | |
| 92 | Walker Buehler# | 2 | 2019-2025 | |
| 92 | Dylan Bundy | 2 | 2012-2023 |
