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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | OOPS | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Sandy Koufax | .5401 | 1955-1966 | |
| 2 | Steve Hamilton | .5591 | 1961-1972 | |
| 3 | Catfish Hunter | .5700 | 1965-1976 | |
| 4 | Larry Dierker | .5817 | 1964-1976 | |
| 5 | Billy O'Dell | .5893 | 1954-1967 | |
| 6 | Bill Stafford | .6012 | 1960-1967 | |
| 7 | Bob Feller | .6022 | 1947-1956 | |
| 8 | Johnny Antonelli | .6096 | 1948-1961 | |
| 9 | Kenley Jansen# | .6123 | 2012-2026 | |
| 10 | Adam Ottavino# | .6252 | 2010-2024 | |
| 11 | Craig Kimbrel# | .6282 | 2011-2026 | |
| 12 | Joe Nathan | .6303 | 2000-2016 | |
| 13 | Shane McClanahan# | .6382 | 2023-2026 | |
| 14 | Aroldis Chapman# | .6389 | 2011-2026 | |
| 15 | Max Scherzer# | .6435 | 2009-2026 | |
| 16 | Johnny Kucks | .6449 | 1955-1960 | |
| 17 | Sean Doolittle | .6452 | 2011-2022 | |
| 18 | Huston Street | .6515 | 2005-2016 | |
| 19 | Tarik Skubal# | .6526 | 2022-2026 | |
| 20 | Jonathan Broxton | .6535 | 2007-2017 | |
| 21 | Andrew Miller | .6574 | 2007-2020 | |
| 22 | Russ Kemmerer | .6585 | 1954-1963 | |
| 23 | Smith Smith | .6592 | 2002-2018 | |
| 24 | Dylan Cease# | .6597 | 2015-2026 | |
| 25 | David Robertson# | .6620 | 2010-2026 | |
| 26 | Stephen Strasburg | .6631 | 2010-2025 | |
| 27 | Jose Alvarez | .6660 | 2010-2023 | |
| 28 | Freddy Peralta# | .6661 | 2019-2026 | |
| 29 | Francisco Rodriguez | .6662 | 2003-2018 | |
| 30 | Lance McCullers Jr.# | .6663 | 2016-2026 | |
| 31 | Raisel Iglesias# | .6675 | 2016-2026 | |
| 32 | Mark Melancon | .6700 | 2010-2023 | |
| 33 | Jonathan Papelbon | .6709 | 2006-2017 | |
| 34 | Yu Darvish# | .6744 | 2012-2026 | |
| 35 | Brad Ziegler | .6750 | 2007-2018 | |
| 36 | Rafael Soriano | .6778 | 2003-2015 | |
| 36 | Blake Snell# | .6778 | 2012-2026 | |
| 38 | Luke Gregerson | .6782 | 2010-2019 | |
| 39 | Felix Hernandez | .6793 | 2005-2021 | |
| 40 | Aaron Nola# | .6799 | 2015-2026 | |
| 41 | Sean Marshall | .6826 | 2007-2016 | |
| 42 | Lucas Giolito# | .6828 | 2016-2026 | |
| 43 | Clayton Kershaw# | .6838 | 2009-2025 | |
| 44 | George Kirby# | .6839 | 2023-2026 | |
| 45 | Jeurys Familia | .6846 | 2010-2022 | |
| 46 | Matt Belisle | .6847 | 2004-2018 | |
| 47 | Trevor Bauer | .6850 | 2012-2023 | |
| 48 | Walker Buehler# | .6859 | 2019-2025 | |
| 49 | Shane Bieber# | .6862 | 2020-2026 | |
| 50 | Jake Peavy | .6866 | 2002-2018 | |
| 51 | Mat Latos | .6867 | 2010-2016 | |
| 52 | Joakim Soria | .6879 | 2007-2020 | |
| 53 | Jacob Degrom# | .6885 | 2012-2026 | |
| 54 | David Price | .6889 | 2009-2023 | |
| 55 | Framber Valdez# | .6893 | 2022-2026 | |
| 56 | Chris Sale# | .6894 | 2011-2026 | |
| 57 | Chad Billingsley | .6903 | 2007-2015 | |
| 58 | Luis Castillo# | .6905 | 2020-2026 | |
| 59 | Justin Verlander# | .6906 | 2007-2026 | |
| 59 | J.P. Howell | .6906 | 2008-2017 | |
| 61 | Josh M. Johnson | .6909 | 2006-2017 | |
| 62 | Hector Rondon | .6911 | 2010-2021 | |
| 63 | Pablo Lopez# | .6912 | 2021-2026 | |
| 64 | Julio Urias# | .6922 | 2018-2025 | |
| 65 | Bryse Wilson# | .6924 | 2020-2026 | |
| 66 | Koji Uehara | .6933 | 2009-2018 | |
| 67 | Darren O'Day | .6937 | 2010-2022 | |
| 68 | Spencer Strider# | .6939 | 2021-2026 | |
| 68 | Jesse Crain | .6939 | 2006-2015 | |
| 70 | Oliver Drake | .6942 | 2010-2022 | |
| 71 | Justin Steele# | .6951 | 2015-2026 | |
| 72 | Tyler Clippard | .6952 | 2007-2019 | |
| 73 | Corbin Burnes# | .6953 | 2020-2025 | |
| 73 | Danny Salazar | .6953 | 2010-2021 | |
| 75 | Sergio Romo | .6955 | 2010-2021 | |
| 76 | Gerrit Cole# | .6972 | 2012-2026 | |
| 77 | Brandon Woodruff# | .6988 | 2015-2026 | |
| 78 | Chaz Roe | .6993 | 2010-2021 | |
| 79 | Zac Gallen# | .6994 | 2020-2026 | |
| 80 | Smith Smith | .6996 | 2005-2015 | |
| 81 | Carlos Rodon# | .7007 | 2015-2026 | |
| 82 | Wade Davis | .7009 | 2009-2020 | |
| 82 | Patrick Corbin# | .7009 | 2012-2026 | |
| 84 | Steve Cishek | .7011 | 2012-2021 | |
| 85 | Joe Smith | .7026 | 2008-2022 | |
| 86 | Hunter Strickland# | .7033 | 2010-2023 | |
| 87 | Brandon Maurer | .7034 | 2010-2018 | |
| 88 | Luis Severino# | .7048 | 2016-2026 | |
| 89 | Marcus Stroman# | .7049 | 2015-2026 | |
| 90 | Cole Hamels | .7055 | 2007-2022 | |
| 91 | Eduardo Rodriguez# | .7057 | 2012-2025 | |
| 92 | Tanner Houck# | .7060 | 2021-2026 | |
| 93 | Caleb Ferguson# | .7070 | 2015-2026 | |
| 94 | Jerry Blevins | .7071 | 2008-2018 | |
| 95 | Collin McHugh | .7076 | 2010-2024 | |
| 96 | Adam Wainwright | .7105 | 2004-2023 | |
| 97 | Sonny Gray# | .7110 | 2012-2026 | |
| 98 | Luke Hochevar | .7113 | 2010-2018 | |
| 99 | Ubaldo Jimenez | .7114 | 2010-2020 | |
| 100 | Tim Lincecum | .7115 | 2009-2018 |
