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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Yoenis Cespedes | 281 | 2012-2020 | |
| 2 | Michael Conforto# | 242 | 2015-2025 | |
| 3 | Justin Upton | 187 | 2007-2022 | |
| 4 | Ryan Braun | 172 | 2008-2020 | |
| 5 | Khris Davis | 162 | 2010-2020 | |
| 6 | Christian Yelich# | 151 | 2015-2025 | |
| 7 | Eddie Rosario# | 139 | 2012-2024 | |
| 8 | Kyle Schwarber# | 135 | 2015-2025 | |
| 9 | Alex Gordon | 130 | 2008-2019 | |
| 10 | Matt Holliday | 122 | 2005-2018 | |
| 11 | Max Muncy# | 119 | 2016-2025 | |
| 12 | Michael Brantley | 116 | 2009-2024 | |
| 13 | David Peralta# | 112 | 2015-2024 | |
| 14 | Corey Dickerson | 111 | 2015-2023 | |
| 15 | Joc Pederson# | 109 | 2012-2025 | |
| 16 | Ronald Acuna Jr.# | 106 | 2019-2025 | |
| 17 | Bob Cerv | 105 | 1951-1962 | |
| 17 | Jesse Winker# | 105 | 2016-2025 | |
| 19 | Carlos Quentin | 103 | 2007-2016 | |
| 20 | Yasmany Tomas | 93 | 2015-2019 | |
| 21 | Matt Joyce | 92 | 2009-2020 | |
| 22 | Mike Trout# | 83 | 2010-2025 | |
| 23 | Austin Meadows# | 82 | 2019-2025 | |
| 24 | Mitch Haniger# | 80 | 2016-2024 | |
| 24 | Tyler O'Neill# | 80 | 2018-2025 | |
| 26 | Hunter Renfroe# | 79 | 2017-2025 | |
| 26 | Bryan Reynolds# | 79 | 2020-2025 | |
| 28 | Smith Smith | 77 | 2005-2014 | |
| 29 | Randy Arozarena# | 72 | 2022-2025 | |
| 29 | Andrew McCutchen# | 72 | 2009-2025 | |
| 31 | Yordan Alvarez# | 71 | 2022-2025 | |
| 31 | Mark Canha# | 71 | 2012-2025 | |
| 31 | Adam Duvall# | 71 | 2014-2024 | |
| 34 | Jake Bauers# | 69 | 2017-2022 | |
| 35 | Domingo Santana# | 66 | 2010-2023 | |
| 36 | Lamonte Wade Jr.# | 62 | 2019-2025 | |
| 37 | Carl Crawford | 61 | 2004-2017 | |
| 38 | Tyrone Taylor# | 60 | 2016-2025 | |
| 39 | Luke Scott | 59 | 2005-2013 | |
| 39 | Seth Smith | 59 | 2008-2018 | |
| 39 | Kyle Tucker# | 59 | 2019-2025 | |
| 42 | Nate McLouth | 58 | 2008-2015 | |
| 43 | Lourdes Gurriel Jr.# | 57 | 2019-2025 | |
| 43 | Yoshitomo Tsutsugo | 57 | 2020-2022 | |
| 43 | Taylor Ward# | 57 | 2022-2025 | |
| 46 | Eloy Jimenez# | 55 | 2019-2025 | |
| 47 | Starling Marte# | 53 | 2014-2025 | |
| 48 | Curtis Granderson | 51 | 2006-2019 | |
| 49 | Alex Verdugo# | 50 | 2015-2025 | |
| 50 | Marcell Ozuna# | 49 | 2012-2025 | |
| 51 | Seth Brown# | 46 | 2022-2025 | |
| 51 | Melky Cabrera | 46 | 2007-2020 | |
| 51 | Andre Ethier | 46 | 2007-2017 | |
| 54 | Jerry Sands | 45 | 2012-2013 | |
| 55 | Ender Inciarte | 42 | 2015-2022 | |
| 56 | Dwight Smith Jr. | 41 | 2012-2021 | |
| 57 | Alec Burleson# | 40 | 2023-2025 | |
| 57 | Jarren Duran# | 40 | 2022-2025 | |
| 59 | Matt Olson# | 39 | 2017-2025 | |
| 60 | Garrett Jones | 37 | 2007-2016 | |
| 61 | Josh Hamilton | 36 | 2008-2017 | |
| 62 | Alex Dickerson | 35 | 2012-2021 | |
| 62 | Randal Grichuk# | 35 | 2010-2025 | |
| 62 | Whit Mayberry | 35 | 2010-2016 | |
| 62 | Scott Schebler | 35 | 2016-2019 | |
| 62 | Nick Williams | 35 | 2017-2020 | |
| 67 | Spencer Steer# | 34 | 2024-2024 | |
| 68 | Dylan Carlson# | 33 | 2021-2025 | |
| 68 | Ian Happ# | 33 | 2018-2025 | |
| 68 | Teoscar Hernandez# | 33 | 2017-2025 | |
| 68 | Scott Van Slyke | 33 | 2012-2018 | |
| 72 | Evan Gattis | 32 | 2014-2019 | |
| 72 | Carlos Peguero | 32 | 2012-2018 | |
| 74 | Nicky Delmonico | 31 | 2012-2018 | |
| 74 | Hanley Ramirez | 31 | 2006-2018 | |
| 74 | Chris B. Young | 31 | 2006-2018 | |
| 77 | Ezequiel Carrera | 30 | 2012-2018 | |
| 78 | Corbin Carroll# | 29 | 2024-2025 | |
| 78 | Chris Coghlan | 29 | 2010-2017 | |
| 78 | Dylan Cozens | 29 | 2019-2019 | |
| 78 | Brandon Nimmo# | 29 | 2012-2025 | |
| 78 | Anthony Santander# | 29 | 2017-2025 | |
| 83 | Nick Franklin | 28 | 2010-2018 | |
| 83 | Logan Morrison | 28 | 2011-2022 | |
| 83 | Josh Reddick | 28 | 2010-2021 | |
| 86 | Andrew Benintendi# | 27 | 2018-2025 | |
| 86 | Bryce Harper# | 27 | 2012-2025 | |
| 88 | Matt Kemp | 26 | 2007-2021 | |
| 88 | Jarrett Parker | 26 | 2012-2020 | |
| 88 | Gerardo Parra | 26 | 2009-2020 | |
| 88 | Alex Presley | 26 | 2011-2017 | |
| 88 | Juan Soto# | 26 | 2019-2025 | |
| 88 | Lane Thomas# | 26 | 2015-2025 | |
| 94 | Kerry Carpenter# | 25 | 2023-2025 | |
| 94 | Chris Carter | 25 | 2009-2017 | |
| 94 | Adam Jones | 25 | 2008-2020 | |
| 94 | Adam Lind | 25 | 2007-2018 | |
| 94 | Nolan Reimold | 25 | 2009-2017 | |
| 94 | Brent Rooker# | 25 | 2021-2025 | |
| 100 | Matt Adams | 24 | 2010-2020 |
