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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Giancarlo Stanton# | 614 | 2011-2025 | |
| 2 | Bryce Harper# | 302 | 2012-2025 | |
| 2 | Aaron Judge# | 302 | 2017-2025 | |
| 4 | Al Kaline | 296 | 1953-1974 | |
| 5 | Juan Soto# | 220 | 2019-2025 | |
| 6 | Max Kepler# | 185 | 2010-2025 | |
| 7 | Joey Gallo# | 166 | 2017-2025 | |
| 8 | Jay Bruce | 165 | 2008-2021 | |
| 9 | Jorge Soler# | 154 | 2016-2025 | |
| 10 | Carlos Gonzalez | 150 | 2008-2019 | |
| 11 | Hunter Renfroe# | 140 | 2017-2025 | |
| 12 | Josh Hamilton | 116 | 2008-2017 | |
| 13 | Nick Markakis | 115 | 2007-2020 | |
| 13 | George Springer# | 115 | 2015-2025 | |
| 15 | Anthony Santander# | 111 | 2017-2025 | |
| 16 | Jason Heyward# | 107 | 2011-2025 | |
| 16 | Stephen Piscotty | 107 | 2016-2022 | |
| 18 | Kole Calhoun | 102 | 2012-2022 | |
| 19 | Avisail Garcia# | 98 | 2013-2024 | |
| 19 | Domingo Santana# | 98 | 2010-2023 | |
| 21 | Marcus Betts# | 97 | 2015-2025 | |
| 21 | Hunter Pence | 97 | 2007-2018 | |
| 23 | Kyle Tucker# | 96 | 2019-2025 | |
| 24 | Jayson Werth | 95 | 2000-2016 | |
| 25 | Nelson Cruz | 93 | 2006-2022 | |
| 26 | Randal Grichuk# | 92 | 2010-2025 | |
| 26 | Josh Reddick | 92 | 2010-2021 | |
| 28 | Oswaldo Arcia | 87 | 2013-2021 | |
| 29 | Domonic Brown | 84 | 2009-2016 | |
| 30 | Brandon Moss | 83 | 2008-2017 | |
| 31 | Eric Thames | 80 | 2012-2020 | |
| 32 | Steven Souza Jr. | 78 | 2010-2021 | |
| 33 | J.D. Martinez# | 74 | 2012-2025 | |
| 34 | Jose Bautista | 73 | 1997-2019 | |
| 34 | Curtis Granderson | 73 | 2006-2019 | |
| 36 | Mitch Haniger# | 72 | 2016-2024 | |
| 36 | Matt Joyce | 72 | 2009-2020 | |
| 38 | Seiya Suzuki# | 71 | 2022-2025 | |
| 39 | Brian Goodwin | 68 | 2012-2021 | |
| 39 | Luke Raley# | 68 | 2023-2025 | |
| 41 | Seth Smith | 67 | 2008-2018 | |
| 42 | Nick Castellanos# | 65 | 2014-2025 | |
| 42 | Teoscar Hernandez# | 65 | 2017-2025 | |
| 42 | Justin Upton | 65 | 2007-2022 | |
| 45 | Nick Swisher | 64 | 2005-2016 | |
| 46 | Adam Jones | 63 | 2008-2020 | |
| 46 | Travis Snider | 63 | 2008-2016 | |
| 48 | Corey Hart | 62 | 2004-2017 | |
| 49 | Andre Ethier | 61 | 2007-2017 | |
| 49 | Smith Smith | 61 | 2000-2017 | |
| 51 | Adolis Garcia# | 60 | 2022-2025 | |
| 52 | Lonnie Chisenhall | 58 | 2012-2020 | |
| 52 | Tommy Pham# | 58 | 2010-2025 | |
| 52 | Fernando Tatis Jr.# | 58 | 2020-2025 | |
| 55 | Ben Zobrist | 57 | 2007-2020 | |
| 56 | Jim Rivera | 56 | 1952-1961 | |
| 57 | Nolan Reimold | 55 | 2009-2017 | |
| 58 | Marcell Ozuna# | 53 | 2012-2025 | |
| 58 | Gregory Polanco# | 53 | 2017-2021 | |
| 60 | Adam Eaton | 52 | 2012-2023 | |
| 60 | Josh Lowe# | 52 | 2021-2025 | |
| 60 | David Murphy | 52 | 2007-2015 | |
| 63 | Jeff Francoeur | 49 | 2006-2017 | |
| 64 | Jesus Sanchez# | 45 | 2021-2025 | |
| 65 | Eddie Rosario# | 44 | 2012-2024 | |
| 66 | Will Benson# | 43 | 2023-2025 | |
| 66 | Ryan Raburn | 43 | 2006-2016 | |
| 66 | Will Venable | 43 | 2009-2014 | |
| 69 | Franchy Cordero# | 42 | 2018-2022 | |
| 69 | Shohei Ohtani# | 42 | 2018-2025 | |
| 69 | Matt Olson# | 42 | 2017-2025 | |
| 69 | Mike Yastrzemski# | 42 | 2020-2025 | |
| 73 | Alex Rios | 41 | 2004-2016 | |
| 74 | Jake Cave# | 40 | 2016-2025 | |
| 75 | Cody Bellinger# | 39 | 2018-2025 | |
| 76 | Kerry Carpenter# | 36 | 2023-2025 | |
| 77 | Wladimir Balentien | 35 | 2007-2015 | |
| 77 | Alex Kirilloff# | 35 | 2020-2025 | |
| 77 | Starling Marte# | 35 | 2014-2025 | |
| 80 | Keon Broxton | 34 | 2010-2020 | |
| 80 | Tyler O'Neill# | 34 | 2018-2025 | |
| 80 | Kevin Pillar | 34 | 2012-2023 | |
| 80 | Scott Schebler | 34 | 2016-2019 | |
| 84 | Josh Bell# | 33 | 2012-2025 | |
| 84 | Jose Martinez | 33 | 2010-2021 | |
| 86 | Chas McCormick# | 32 | 2021-2025 | |
| 87 | Matt Kemp | 31 | 2007-2021 | |
| 87 | Andrew Lambo | 31 | 2011-2015 | |
| 87 | Luke Scott | 31 | 2005-2013 | |
| 90 | Brandon Guyer | 30 | 2011-2018 | |
| 90 | MJ Melendez# | 30 | 2023-2024 | |
| 92 | Rece Hinds# | 29 | 2024-2025 | |
| 92 | Gerardo Parra | 29 | 2009-2020 | |
| 92 | Jack Suwinski# | 29 | 2023-2025 | |
| 95 | Roger Kieschnick | 28 | 2010-2014 | |
| 95 | Dave Winfield | 28 | 1973-1976 | |
| 97 | Daniel Murphy | 27 | 2009-2022 | |
| 97 | Chris Parmelee | 27 | 2012-2018 | |
| 97 | Smith Smith | 27 | 2005-2014 | |
| 100 | Jake Fraley# | 26 | 2020-2025 |
