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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | IP | YEAR | Open Postseason Career Leaderboard |
|---|---|---|---|---|
| 1 | Clayton Kershaw# | 42.0 | 2015 | |
| 2 | Max Scherzer# | 39.0 | 2013 | |
| 3 | Madison Bumgarner | 36.0 | 2018 | |
| 4 | Gio Gonzalez | 35.0 | 2014 | |
| 4 | Jacob Degrom# | 35.0 | 2024 | |
| 6 | Yu Darvish# | 34.0 | 2013 | |
| 7 | Stephen Strasburg# | 33.0 | 2015 | |
| 8 | Aaron Nola# | 32.0 | 2019 | |
| 8 | Max Scherzer# | 32.0 | 2018 | |
| 8 | Justin Souza | 32.0 | 2012 | |
| 8 | Corbin Burnes# | 32.0 | 2024 | |
| 8 | Madison Bumgarner | 32.0 | 2017 | |
| 13 | David Price | 31.0 | 2016 | |
| 13 | Catfish Hunter | 31.0 | 1972 | |
| 15 | Jon Niese | 30.0 | 2014 | |
| 15 | Corey Kluber | 30.0 | 2016 | |
| 15 | Edinson Volquez | 30.0 | 2014 | |
| 15 | David Price | 30.0 | 2015 | |
| 15 | Homer Bailey | 30.0 | 2016 | |
| 15 | Pablo Lopez# | 30.0 | 2024 | |
| 15 | Chris Jones | 30.0 | 2012 | |
| 22 | Mat Latos | 29.0 | 2015 | |
| 22 | Catfish Hunter | 29.0 | 1973 | |
| 22 | Christian Friedrich | 29.0 | 2011 | |
| 25 | Adam Wainwright | 28.0 | 2017 | |
| 25 | Carlos Carrasco | 28.0 | 2021 | |
| 25 | Wade Davis | 28.0 | 2013 | |
| 25 | Kyle Hendricks# | 28.0 | 2022 | |
| 25 | Jose Junior Rosario | 28.0 | 2012 | |
| 25 | Jose Quintana# | 28.0 | 2018 | |
| 25 | Gerrit Cole# | 28.0 | 2018 | |
| 32 | Miguel Celestino | 27.0 | 2012 | |
| 32 | Kevin Gausman# | 27.0 | 2022 | |
| 32 | Blake Snell# | 27.0 | 2022 | |
| 32 | Gerrit Cole# | 27.0 | 2017 | |
| 36 | Patrick Sandoval# | 26.0 | 2022 | |
| 36 | Justin Verlander# | 26.0 | 2015 | |
| 36 | Aaron Nola# | 26.0 | 2017 | |
| 39 | German Marquez# | 25.0 | 2022 | |
| 39 | Clayton Kershaw# | 25.0 | 2021 | |
| 39 | Ross Detwiler | 25.0 | 2013 | |
| 39 | Matt Manning# | 25.0 | 2022 | |
| 43 | Hyun-Jin Ryu | 24.0 | 2020 | |
| 43 | David Price | 24.0 | 2017 | |
| 43 | Carlos Carrasco | 24.0 | 2019 | |
| 43 | Sandy Koufax | 24.0 | 1965 | |
| 43 | Jeurys Familia | 24.0 | 2011 | |
| 43 | Erik Davis | 24.0 | 2012 | |
| 49 | John Danks | 23.0 | 2013 | |
| 49 | Marcus Stroman# | 23.0 | 2017 | |
| 49 | Corbin Burnes# | 23.0 | 2023 | |
| 49 | Carlos Rodon# | 23.0 | 2024 | |
| 49 | Miles Mikolas# | 23.0 | 2021 | |
| 54 | Matthew Boyd# | 22.0 | 2021 | |
| 54 | Jeff Ames | 22.0 | 2012 | |
| 54 | Shohei Ohtani# | 22.0 | 2023 | |
| 54 | Jeremy Hellickson | 22.0 | 2014 | |
| 54 | Marcus Stroman# | 22.0 | 2015 | |
| 54 | Tyler Mahle# | 22.0 | 2021 | |
| 54 | Walker Buehler# | 22.0 | 2020 | |
| 61 | Shohei Ohtani# | 21.0 | 2020 | |
| 61 | Aaron Nola# | 21.0 | 2021 | |
| 61 | Maikel Cleto | 21.0 | 2012 | |
| 61 | Kodai Senga# | 21.0 | 2023 | |
| 61 | Carlos Frias | 21.0 | 2012 | |
| 61 | Luis Patino# | 21.0 | 2022 | |
| 61 | Justin Verlander# | 21.0 | 2020 | |
| 61 | Josh Smoker | 21.0 | 2012 | |
| 61 | Nick Martinez# | 21.0 | 2024 | |
| 61 | Smith Smith | 21.0 | 2013 | |
| 61 | Jaime Garcia | 21.0 | 2014 | |
| 72 | Shane McClanahan# | 20.0 | 2023 | |
| 72 | Catfish Hunter | 20.0 | 1976 | |
| 72 | Jeurys Familia | 20.0 | 2012 | |
| 72 | Collin McHugh | 20.0 | 2016 | |
| 72 | Lisalberto Bonilla | 20.0 | 2012 | |
| 72 | Johnny Cueto | 20.0 | 2017 | |
| 72 | Chris Archer | 20.0 | 2019 | |
| 72 | Cory Luebke | 20.0 | 2013 | |
| 72 | Zack Wheeler# | 20.0 | 2019 | |
| 72 | Johnny Cueto | 20.0 | 2021 | |
| 72 | German Marquez# | 20.0 | 2018 | |
| 72 | Lance McCullers Jr.# | 20.0 | 2021 | |
| 72 | Lance McCullers Jr.# | 20.0 | 2017 | |
| 72 | Kendry Flores | 20.0 | 2019 | |
| 72 | Shawn Armstrong# | 20.0 | 2012 | |
| 87 | Chad Bettis | 19.0 | 2012 | |
| 87 | Vladimir Gutierrez# | 19.0 | 2022 | |
| 87 | Aaron Nola# | 19.0 | 2023 | |
| 87 | Jake Odorizzi | 19.0 | 2019 | |
| 87 | Justin Verlander# | 19.0 | 2014 | |
| 87 | Chris Paddack# | 19.0 | 2023 | |
| 87 | Lance McCullers Jr.# | 19.0 | 2019 | |
| 87 | Catfish Hunter | 19.0 | 1974 | |
| 87 | Walker Buehler# | 19.0 | 2024 | |
| 87 | Jake Odorizzi | 19.0 | 2016 | |
| 87 | Luke Weaver# | 19.0 | 2022 | |
| 87 | Justin Masterson | 19.0 | 2013 | |
| 87 | Merrill Kelly# | 19.0 | 2024 | |
| 87 | Matt Moore# | 19.0 | 2014 |
