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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K9 | YEAR | Open Postseason Career Leaderboard |
|---|---|---|---|---|
| 1 | Justin Wilson | 15.88 | 2018 | |
| 2 | Blake Snell# | 15.51 | 2024 | |
| 3 | Corbin Burnes# | 14.87 | 2023 | |
| 4 | Stephen Strasburg# | 13.91 | 2015 | |
| 5 | Walker Buehler# | 12.68 | 2020 | |
| 6 | Justin Verlander# | 12.66 | 2020 | |
| 7 | Derek Holland | 12.60 | 2013 | |
| 7 | Wily Peralta | 12.60 | 2013 | |
| 9 | Shohei Ohtani# | 12.31 | 2023 | |
| 10 | Madison Bumgarner | 11.53 | 2017 | |
| 11 | Sandy Koufax | 11.50 | 1963 | |
| 12 | Justin Verlander# | 11.42 | 2015 | |
| 13 | Grant Dayton | 11.40 | 2021 | |
| 14 | Matt Moore# | 11.37 | 2014 | |
| 15 | Nathan Eovaldi# | 11.29 | 2022 | |
| 16 | Mat Latos | 11.22 | 2015 | |
| 17 | Nick Anderson# | 11.15 | 2020 | |
| 18 | David Price | 11.10 | 2017 | |
| 19 | Matt Cain | 10.90 | 2015 | |
| 20 | Sandy Koufax | 10.88 | 1965 | |
| 21 | Blake Snell# | 10.87 | 2022 | |
| 22 | Jon Niese | 10.86 | 2014 | |
| 23 | Zack Wheeler# | 10.80 | 2018 | |
| 23 | Aaron Nola# | 10.80 | 2021 | |
| 25 | Ryan Helsley# | 10.26 | 2020 | |
| 26 | Jacob Degrom# | 10.20 | 2017 | |
| 26 | Carlos Carrasco | 10.20 | 2016 | |
| 28 | Gio Gonzalez | 10.19 | 2014 | |
| 29 | Jeurys Familia | 10.12 | 2011 | |
| 30 | Marcus Stroman# | 10.07 | 2015 | |
| 31 | Matt Harvey | 10.06 | 2015 | |
| 32 | Shohei Ohtani# | 9.97 | 2020 | |
| 33 | Pablo Lopez# | 9.90 | 2024 | |
| 33 | Lance McCullers Jr.# | 9.90 | 2017 | |
| 35 | Patrick Sandoval# | 9.79 | 2022 | |
| 36 | Clayton Kershaw# | 9.70 | 2015 | |
| 37 | Zack Wheeler# | 9.68 | 2014 | |
| 38 | David Price | 9.66 | 2016 | |
| 39 | Gerrit Cole# | 9.64 | 2018 | |
| 40 | Freddy Peralta# | 9.60 | 2021 | |
| 41 | Yu Darvish# | 9.56 | 2018 | |
| 42 | Tyler Mahle# | 9.53 | 2018 | |
| 42 | Jose Junior Rosario | 9.53 | 2012 | |
| 44 | David Price | 9.49 | 2015 | |
| 45 | Justin Masterson | 9.47 | 2013 | |
| 46 | Yu Darvish# | 9.44 | 2013 | |
| 47 | Hisashi Iwakuma | 9.37 | 2015 | |
| 48 | Chris Paddack# | 9.31 | 2023 | |
| 49 | Smith Smith | 9.28 | 2013 | |
| 50 | Christian Friedrich | 9.20 | 2011 | |
| 51 | Shelby Miller# | 9.19 | 2015 | |
| 52 | Ryan Pressley | 9.17 | 2012 | |
| 53 | Andrew Cashner | 9.16 | 2013 | |
| 54 | Aaron Nola# | 9.15 | 2023 | |
| 55 | Jaime Garcia | 9.00 | 2014 | |
| 55 | Erik Davis | 9.00 | 2012 | |
| 57 | Max Scherzer# | 8.92 | 2013 | |
| 58 | Edinson Volquez | 8.90 | 2014 | |
| 59 | Zack Wheeler# | 8.85 | 2019 | |
| 59 | Collin McHugh | 8.85 | 2016 | |
| 59 | Johnny Cueto | 8.85 | 2017 | |
| 62 | Martin Perez# | 8.80 | 2015 | |
| 63 | Jacob Degrom# | 8.74 | 2024 | |
| 64 | Adam Wainwright | 8.68 | 2016 | |
| 65 | Aaron Nola# | 8.65 | 2017 | |
| 66 | Aaron Nola# | 8.63 | 2019 | |
| 67 | Carlos Rodon# | 8.61 | 2024 | |
| 68 | Kendry Flores | 8.55 | 2019 | |
| 69 | Matt Manning# | 8.53 | 2022 | |
| 70 | Tim Crabbe | 8.44 | 2011 | |
| 70 | Nick Martinez# | 8.44 | 2024 | |
| 70 | Corbin Burnes# | 8.44 | 2024 | |
| 73 | Hyun-Jin Ryu | 8.39 | 2020 | |
| 74 | Luke Weaver# | 8.38 | 2022 | |
| 75 | Corey Kluber | 8.22 | 2016 | |
| 76 | Lance McCullers Jr.# | 8.10 | 2021 | |
| 77 | German Marquez# | 8.06 | 2022 | |
| 78 | Merrill Kelly# | 8.05 | 2024 | |
| 79 | Smith Smith | 8.04 | 2016 | |
| 80 | Justin Steele# | 8.00 | 2024 | |
| 80 | Julio Urias# | 8.00 | 2023 | |
| 82 | Chris Archer | 7.97 | 2019 | |
| 83 | Jake Odorizzi | 7.91 | 2016 | |
| 84 | Kevin Gausman# | 7.90 | 2022 | |
| 85 | Maikel Cleto | 7.89 | 2012 | |
| 86 | Luis Castillo# | 7.80 | 2023 | |
| 87 | Justin Verlander# | 7.78 | 2014 | |
| 88 | Madison Bumgarner | 7.68 | 2018 | |
| 89 | John Danks | 7.61 | 2013 | |
| 90 | Miles Mikolas# | 7.41 | 2018 | |
| 90 | Jacob Degrom# | 7.41 | 2021 | |
| 92 | Shane McClanahan# | 7.40 | 2023 | |
| 93 | Jose Quintana# | 7.39 | 2018 | |
| 94 | Scott Baker | 7.23 | 2013 | |
| 95 | Chris Jones | 7.20 | 2012 | |
| 96 | Homer Bailey | 7.12 | 2016 | |
| 97 | Colin Rea# | 7.04 | 2016 | |
| 98 | Jon Gray# | 7.02 | 2019 | |
| 99 | Clayton Kershaw# | 7.01 | 2021 | |
| 100 | Gerrit Cole# | 7.00 | 2017 |
