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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | W | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Max Scherzer# | 10 | 2009-2025 | |
| 2 | Catfish Hunter | 8 | 1965-1976 | |
| 2 | Aaron Nola# | 8 | 2015-2025 | |
| 4 | Carlos Carrasco | 7 | 2010-2023 | |
| 5 | Corbin Burnes# | 6 | 2020-2024 | |
| 5 | Jacob Degrom# | 6 | 2012-2025 | |
| 5 | Clayton Kershaw# | 6 | 2009-2025 | |
| 5 | Lance McCullers Jr.# | 6 | 2016-2025 | |
| 9 | Gerrit Cole# | 5 | 2012-2025 | |
| 9 | Craig Kimbrel# | 5 | 2011-2025 | |
| 9 | Justin Verlander# | 5 | 2007-2025 | |
| 9 | Zack Wheeler# | 5 | 2010-2025 | |
| 13 | Madison Bumgarner | 4 | 2011-2023 | |
| 13 | Josh Hader# | 4 | 2017-2025 | |
| 13 | Corey Kluber | 4 | 2011-2023 | |
| 13 | Sandy Koufax | 4 | 1955-1966 | |
| 13 | Mat Latos | 4 | 2010-2016 | |
| 13 | Shohei Ohtani# | 4 | 2018-2025 | |
| 13 | David Price | 4 | 2009-2023 | |
| 13 | Blake Snell# | 4 | 2012-2025 | |
| 13 | Adam Wainwright | 4 | 2004-2023 | |
| 22 | Dan Altavilla# | 3 | 2015-2021 | |
| 22 | Chris Archer | 3 | 2012-2023 | |
| 22 | Matt Boyd# | 3 | 2019-2024 | |
| 22 | Walker Buehler# | 3 | 2019-2025 | |
| 22 | Wade Davis | 3 | 2009-2020 | |
| 22 | Ross Detwiler | 3 | 2011-2023 | |
| 22 | Edwin Diaz# | 3 | 2017-2025 | |
| 22 | Jeurys Familia | 3 | 2010-2022 | |
| 22 | Gio Gonzalez | 3 | 2010-2022 | |
| 22 | Kyle Hendricks# | 3 | 2016-2024 | |
| 22 | Liam Hendriks# | 3 | 2012-2025 | |
| 22 | Raisel Iglesias# | 3 | 2016-2025 | |
| 22 | Merrill Kelly# | 3 | 2019-2024 | |
| 22 | Andrew Kittredge# | 3 | 2019-2024 | |
| 22 | Pablo Lopez# | 3 | 2021-2025 | |
| 22 | Tyler Mahle# | 3 | 2017-2025 | |
| 22 | Matt Manning# | 3 | 2021-2025 | |
| 22 | Shane McClanahan# | 3 | 2023-2025 | |
| 22 | Collin McHugh | 3 | 2010-2024 | |
| 22 | Miles Mikolas# | 3 | 2010-2025 | |
| 22 | Jose Quintana# | 3 | 2013-2025 | |
| 22 | David Robertson# | 3 | 2010-2025 | |
| 22 | Carlos Rodon# | 3 | 2015-2025 | |
| 22 | Patrick Sandoval# | 3 | 2021-2025 | |
| 22 | Marcus Stroman# | 3 | 2015-2024 | |
| 22 | Logan Webb# | 3 | 2015-2025 | |
| 22 | Justin Wilson | 3 | 2010-2021 | |
| 22 | Nick Wittgren# | 3 | 2016-2021 | |
| 50 | Sandy Alcantara# | 2 | 2018-2025 | |
| 50 | Nick Anderson# | 2 | 2020-2025 | |
| 50 | Homer Bailey | 2 | 2009-2020 | |
| 50 | Trevor Bauer | 2 | 2012-2023 | |
| 50 | Lisalberto Bonilla | 2 | 2012-2012 | |
| 50 | Ryan Brasier# | 2 | 2010-2025 | |
| 50 | Aaron Bummer# | 2 | 2015-2025 | |
| 50 | Andrew Cashner | 2 | 2011-2020 | |
| 50 | Luis Castillo# | 2 | 2020-2025 | |
| 50 | Miguel Celestino | 2 | 2012-2012 | |
| 50 | Maikel Cleto | 2 | 2010-2017 | |
| 50 | Johnny Cueto | 2 | 2010-2023 | |
| 50 | Yu Darvish# | 2 | 2012-2025 | |
| 50 | Erik Davis | 2 | 2010-2015 | |
| 50 | Danny Farquhar | 2 | 2010-2018 | |
| 50 | Max Fried# | 2 | 2018-2025 | |
| 50 | Kyuji Fujikawa | 2 | 2013-2016 | |
| 50 | Jon Gray# | 2 | 2015-2025 | |
| 50 | Matt Harvey | 2 | 2014-2021 | |
| 50 | Derek Holland | 2 | 2010-2019 | |
| 50 | Tommy Hunter | 2 | 2010-2020 | |
| 50 | Jeff Inman | 2 | 2010-2012 | |
| 50 | Kenley Jansen# | 2 | 2012-2025 | |
| 50 | Chris Jones | 2 | 2010-2012 | |
| 50 | Yusei Kikuchi# | 2 | 2019-2025 | |
| 50 | Jose Leclerc# | 2 | 2018-2025 | |
| 50 | Michael Lorenzen# | 2 | 2018-2025 | |
| 50 | Cory Luebke | 2 | 2011-2015 | |
| 50 | Matt Magill | 2 | 2010-2013 | |
| 50 | Steve Matz# | 2 | 2010-2025 | |
| 50 | Jon Niese | 2 | 2009-2016 | |
| 50 | Jake Odorizzi | 2 | 2012-2023 | |
| 50 | Josh Osich | 2 | 2012-2019 | |
| 50 | Dan Otero | 2 | 2010-2019 | |
| 50 | Jarrod Parker | 2 | 2012-2015 | |
| 50 | Joel Peralta | 2 | 2005-2016 | |
| 50 | Ryan Pressley | 2 | 2010-2012 | |
| 50 | Garrett Richards | 2 | 2012-2022 | |
| 50 | Chaz Roe | 2 | 2010-2021 | |
| 50 | Sergio Romo | 2 | 2010-2021 | |
| 50 | Jose Junior Rosario | 2 | 2012-2017 | |
| 50 | Hyun-Jin Ryu | 2 | 2013-2023 | |
| 50 | Dennis Santana# | 2 | 2021-2025 | |
| 50 | Luis Severino# | 2 | 2016-2025 | |
| 50 | James Sherfy | 2 | 2017-2021 | |
| 50 | Lucas Sims# | 2 | 2019-2023 | |
| 50 | Tarik Skubal# | 2 | 2022-2025 | |
| 50 | Smith Smith | 2 | 2004-2017 | |
| 50 | Justin Souza | 2 | 2012-2012 | |
| 50 | Jeffrey Springs# | 2 | 2021-2024 | |
| 50 | Huston Street | 2 | 2005-2016 |
