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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | G | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Craig Kimbrel# | 38 | 2011-2025 | |
| 2 | Jose Leclerc# | 31 | 2018-2025 | |
| 3 | Dellin Betances | 30 | 2011-2021 | |
| 4 | Darren O'Day | 27 | 2010-2022 | |
| 5 | Wade Davis | 25 | 2009-2020 | |
| 6 | Ryan Brasier# | 24 | 2010-2025 | |
| 7 | Josh Hader# | 23 | 2017-2025 | |
| 8 | Jose Alvarado# | 22 | 2018-2025 | |
| 9 | Giovanny Gallegos# | 21 | 2018-2025 | |
| 9 | Andrew Kittredge# | 21 | 2019-2025 | |
| 9 | Aaron Nola# | 21 | 2015-2025 | |
| 9 | David Robertson# | 21 | 2010-2025 | |
| 9 | Justin Wilson | 21 | 2010-2021 | |
| 14 | Peter Fairbanks# | 20 | 2020-2025 | |
| 14 | David Price | 20 | 2009-2023 | |
| 14 | Justin Verlander# | 20 | 2007-2025 | |
| 17 | Ryan Pressly# | 19 | 2016-2025 | |
| 17 | Tony Watson | 19 | 2011-2021 | |
| 19 | Trevor Megill# | 18 | 2020-2025 | |
| 19 | Taylor Rogers# | 18 | 2018-2025 | |
| 19 | Jeffrey Springs# | 18 | 2021-2025 | |
| 19 | Ryne Stanek# | 18 | 2017-2025 | |
| 23 | Corbin Burnes# | 17 | 2020-2025 | |
| 23 | Aroldis Chapman# | 17 | 2011-2025 | |
| 23 | Catfish Hunter | 17 | 1965-1976 | |
| 23 | Max Scherzer# | 17 | 2009-2025 | |
| 27 | Grant Dayton | 16 | 2012-2021 | |
| 27 | Jacob Degrom# | 16 | 2012-2025 | |
| 27 | Clay Holmes# | 16 | 2012-2025 | |
| 27 | Michael Lorenzen# | 16 | 2018-2025 | |
| 27 | Chaz Roe | 16 | 2010-2021 | |
| 27 | Logan Webb# | 16 | 2015-2025 | |
| 27 | Kirby Yates# | 16 | 2018-2025 | |
| 34 | Archie Bradley | 15 | 2012-2022 | |
| 34 | Liam Hendriks# | 15 | 2012-2025 | |
| 34 | Kenley Jansen# | 15 | 2012-2025 | |
| 34 | Mark Melancon | 15 | 2010-2023 | |
| 34 | Zach Putnam | 15 | 2010-2018 | |
| 34 | Alex Vesia# | 15 | 2020-2025 | |
| 40 | Andrew Chafin# | 14 | 2012-2025 | |
| 40 | Edwin Diaz# | 14 | 2017-2025 | |
| 40 | Ryan Helsley# | 14 | 2020-2025 | |
| 40 | Keone Kela | 14 | 2016-2022 | |
| 40 | Clayton Kershaw# | 14 | 2009-2025 | |
| 40 | Dan Otero | 14 | 2010-2019 | |
| 40 | Adam Ottavino# | 14 | 2010-2024 | |
| 40 | Drew Pomeranz | 14 | 2012-2023 | |
| 40 | Garrett Whitlock# | 14 | 2021-2025 | |
| 40 | Brad Ziegler | 14 | 2007-2018 | |
| 50 | Scott Barlow# | 13 | 2020-2025 | |
| 50 | Gerrit Cole# | 13 | 2012-2025 | |
| 50 | Alex Colome | 13 | 2010-2022 | |
| 50 | Seranthony Dominguez# | 13 | 2019-2025 | |
| 50 | Luke Gregerson | 13 | 2010-2019 | |
| 50 | Raisel Iglesias# | 13 | 2016-2025 | |
| 50 | Pablo Lopez# | 13 | 2021-2025 | |
| 50 | Oliver Perez | 13 | 2003-2022 | |
| 50 | Hector Rondon | 13 | 2010-2021 | |
| 50 | Matt Strahm# | 13 | 2016-2025 | |
| 50 | Zack Wheeler# | 13 | 2010-2025 | |
| 61 | Dan Altavilla# | 12 | 2015-2021 | |
| 61 | Sean Doolittle | 12 | 2011-2022 | |
| 61 | Carl Edwards Jr.# | 12 | 2012-2024 | |
| 61 | Joe Jimenez# | 12 | 2018-2025 | |
| 61 | Luke Leftwich# | 12 | 2019-2021 | |
| 61 | A.J. Minter# | 12 | 2019-2025 | |
| 61 | Matt Moore# | 12 | 2012-2025 | |
| 61 | Colton Murray | 12 | 2012-2021 | |
| 61 | Jake Odorizzi | 12 | 2012-2023 | |
| 61 | Jordan Romano# | 12 | 2015-2025 | |
| 61 | Hyun-Jin Ryu | 12 | 2013-2023 | |
| 61 | Marcus Stroman# | 12 | 2015-2025 | |
| 61 | Blake Treinen# | 12 | 2012-2025 | |
| 61 | Julio Urias# | 12 | 2018-2025 | |
| 75 | Fernando Abad | 11 | 2012-2018 | |
| 75 | Nick Anderson# | 11 | 2020-2025 | |
| 75 | Madison Bumgarner | 11 | 2011-2023 | |
| 75 | Carlos Carrasco | 11 | 2010-2023 | |
| 75 | Yu Darvish# | 11 | 2012-2025 | |
| 75 | Steve Delabar | 11 | 2013-2017 | |
| 75 | Tommy Hunter | 11 | 2010-2020 | |
| 75 | Carlos Martinez | 11 | 2016-2022 | |
| 75 | Shane McClanahan# | 11 | 2023-2025 | |
| 75 | Lance McCullers Jr.# | 11 | 2016-2025 | |
| 75 | Jake McGee | 11 | 2010-2022 | |
| 75 | Miles Mikolas# | 11 | 2010-2025 | |
| 75 | Hoby Milner# | 11 | 2020-2025 | |
| 75 | Sam Moll# | 11 | 2024-2025 | |
| 75 | Charlie Morton# | 11 | 2010-2025 | |
| 75 | Shohei Ohtani# | 11 | 2018-2025 | |
| 75 | Chris Perez | 11 | 2011-2015 | |
| 75 | Carlos Rodon# | 11 | 2015-2025 | |
| 75 | Bryan Shaw | 11 | 2012-2021 | |
| 75 | Joakim Soria | 11 | 2007-2020 | |
| 75 | Huston Street | 11 | 2005-2016 | |
| 96 | Chad Bettis | 10 | 2012-2019 | |
| 96 | Walker Buehler# | 10 | 2019-2025 | |
| 96 | J.T. Chargois# | 10 | 2016-2023 | |
| 96 | Tyler Clippard | 10 | 2007-2019 | |
| 96 | Nathan Eovaldi# | 10 | 2012-2025 |
