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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Max Scherzer# | 18 | 2009-2025 | |
| 2 | David Price | 17 | 2009-2023 | |
| 3 | Pablo Lopez# | 16 | 2021-2025 | |
| 4 | Clayton Kershaw# | 14 | 2009-2025 | |
| 5 | Catfish Hunter | 13 | 1965-1976 | |
| 6 | Corbin Burnes# | 12 | 2020-2025 | |
| 6 | Julio Urias# | 12 | 2018-2025 | |
| 8 | Jacob Degrom# | 11 | 2012-2025 | |
| 8 | Marcus Stroman# | 11 | 2015-2025 | |
| 10 | Aaron Nola# | 10 | 2015-2025 | |
| 10 | Justin Verlander# | 10 | 2007-2025 | |
| 10 | Zack Wheeler# | 10 | 2010-2025 | |
| 13 | Walker Buehler# | 9 | 2019-2025 | |
| 13 | Miles Mikolas# | 9 | 2010-2025 | |
| 13 | Robbie Ray# | 9 | 2017-2025 | |
| 13 | Carlos Rodon# | 9 | 2015-2025 | |
| 13 | Hyun-Jin Ryu | 9 | 2013-2023 | |
| 18 | Kevin Gausman# | 8 | 2013-2025 | |
| 18 | Tyler Mahle# | 8 | 2017-2025 | |
| 18 | Nick Martinez# | 8 | 2012-2025 | |
| 18 | Jake Odorizzi | 8 | 2012-2023 | |
| 18 | Shohei Ohtani# | 8 | 2018-2025 | |
| 18 | Adam Wainwright | 8 | 2004-2023 | |
| 24 | Chad Bettis | 7 | 2012-2019 | |
| 24 | Matthew Boyd# | 7 | 2019-2025 | |
| 24 | Johnny Cueto | 7 | 2010-2023 | |
| 24 | Max Fried# | 7 | 2018-2025 | |
| 24 | Matt Harvey | 7 | 2014-2021 | |
| 24 | Shelby Miller# | 7 | 2012-2023 | |
| 24 | Freddy Peralta# | 7 | 2019-2025 | |
| 24 | James Shields | 7 | 2007-2019 | |
| 24 | Brandon Workman | 7 | 2012-2021 | |
| 33 | Carlos Carrasco | 6 | 2010-2023 | |
| 33 | Dylan Cease# | 6 | 2015-2025 | |
| 33 | Wade Davis | 6 | 2009-2020 | |
| 33 | Nathan Eovaldi# | 6 | 2012-2025 | |
| 33 | Lucas Giolito# | 6 | 2016-2025 | |
| 33 | Zachary Godley | 6 | 2017-2021 | |
| 33 | Corey Kluber | 6 | 2011-2023 | |
| 33 | Lance McCullers Jr.# | 6 | 2016-2025 | |
| 33 | Trevor Megill# | 6 | 2020-2025 | |
| 33 | Charlie Morton# | 6 | 2010-2025 | |
| 33 | Chris Paddack# | 6 | 2020-2025 | |
| 33 | Trevor Richards# | 6 | 2019-2022 | |
| 33 | Blake Snell# | 6 | 2012-2025 | |
| 33 | Edinson Volquez | 6 | 2008-2020 | |
| 47 | Sandy Alcantara# | 5 | 2018-2025 | |
| 47 | Ryan Brasier# | 5 | 2010-2025 | |
| 47 | Madison Bumgarner | 5 | 2011-2023 | |
| 47 | Wei-Yin Chen | 5 | 2012-2018 | |
| 47 | Gerrit Cole# | 5 | 2012-2025 | |
| 47 | John Danks | 5 | 2008-2018 | |
| 47 | Zachary Davies | 5 | 2012-2023 | |
| 47 | Ross Detwiler | 5 | 2011-2023 | |
| 47 | Ryan Feltner# | 5 | 2023-2025 | |
| 47 | Dylan File# | 5 | 2022-2022 | |
| 47 | Vladimir Gutierrez# | 5 | 2022-2024 | |
| 47 | Derek Holland | 5 | 2010-2019 | |
| 47 | Keone Kela | 5 | 2016-2022 | |
| 47 | Jose Leclerc# | 5 | 2018-2025 | |
| 47 | Jon Lester | 5 | 2007-2021 | |
| 47 | Lance Lynn# | 5 | 2010-2025 | |
| 47 | German Marquez# | 5 | 2018-2025 | |
| 47 | Michael Pineda | 5 | 2011-2023 | |
| 47 | Chris Sale# | 5 | 2011-2025 | |
| 47 | Smith Smith | 5 | 2004-2017 | |
| 47 | Logan Webb# | 5 | 2015-2025 | |
| 68 | Homer Bailey | 4 | 2009-2020 | |
| 68 | Connor Brogdon# | 4 | 2023-2024 | |
| 68 | Hunter Brown# | 4 | 2024-2025 | |
| 68 | David Carpenter | 4 | 2012-2016 | |
| 68 | Yu Darvish# | 4 | 2012-2025 | |
| 68 | Grant Dayton | 4 | 2012-2021 | |
| 68 | Zach Eflin# | 4 | 2018-2025 | |
| 68 | Hunter Gaddis# | 4 | 2024-2025 | |
| 68 | Zac Gallen# | 4 | 2020-2025 | |
| 68 | Ryan Helsley# | 4 | 2020-2025 | |
| 68 | James Hoyt | 4 | 2017-2021 | |
| 68 | Kenley Jansen# | 4 | 2012-2025 | |
| 68 | Pierce Johnson# | 4 | 2016-2025 | |
| 68 | Jakob Junis# | 4 | 2012-2025 | |
| 68 | Merrill Kelly# | 4 | 2019-2025 | |
| 68 | Yusei Kikuchi# | 4 | 2019-2025 | |
| 68 | Shane McClanahan# | 4 | 2023-2025 | |
| 68 | Scott McGough# | 4 | 2012-2024 | |
| 68 | Matt Moore# | 4 | 2012-2025 | |
| 68 | Ryan Pressley | 4 | 2010-2012 | |
| 68 | Jose Quintana# | 4 | 2013-2025 | |
| 68 | Anibal Sanchez | 4 | 2007-2021 | |
| 68 | Tarik Skubal# | 4 | 2022-2025 | |
| 68 | Jeffrey Springs# | 4 | 2021-2025 | |
| 68 | Luke Weaver# | 4 | 2015-2025 | |
| 68 | Gavin Williams# | 4 | 2025-2025 | |
| 94 | Jose Alvarado# | 3 | 2018-2025 | |
| 94 | Tyler Anderson# | 3 | 2012-2025 | |
| 94 | Chris Archer | 3 | 2012-2023 | |
| 94 | Jake Arrieta | 3 | 2011-2022 | |
| 94 | Graham Ashcraft# | 3 | 2024-2025 | |
| 94 | Scott Baker | 3 | 2006-2014 | |
| 94 | Grant Balfour | 3 | 2005-2014 |
