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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | SV | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Craig Kimbrel# | 19 | 2011-2025 | |
| 2 | Josh Hader# | 9 | 2017-2025 | |
| 3 | Dellin Betances | 8 | 2011-2021 | |
| 3 | Giovanny Gallegos# | 8 | 2018-2025 | |
| 5 | Wade Davis | 7 | 2009-2020 | |
| 5 | Peter Fairbanks# | 7 | 2020-2025 | |
| 5 | Luke Gregerson | 7 | 2010-2019 | |
| 8 | Edwin Diaz# | 6 | 2017-2025 | |
| 8 | Seranthony Dominguez# | 6 | 2019-2025 | |
| 8 | Tanner Scott# | 6 | 2020-2025 | |
| 8 | Huston Street | 6 | 2005-2016 | |
| 12 | Archie Bradley | 5 | 2012-2022 | |
| 12 | Ernesto Frieri | 5 | 2011-2015 | |
| 12 | Darren O'Day | 5 | 2010-2022 | |
| 12 | Bobby Parnell | 5 | 2009-2016 | |
| 12 | Zach Putnam | 5 | 2010-2018 | |
| 12 | Chaz Roe | 5 | 2010-2021 | |
| 12 | Taylor Rogers# | 5 | 2018-2025 | |
| 12 | Matt Strahm# | 5 | 2016-2025 | |
| 12 | Pat Venditte | 5 | 2010-2012 | |
| 12 | Jason Wheeler | 5 | 2012-2012 | |
| 22 | Felix Bautista# | 4 | 2023-2025 | |
| 22 | Aroldis Chapman# | 4 | 2011-2025 | |
| 22 | Fernando Cruz# | 4 | 2025-2025 | |
| 22 | Michael King# | 4 | 2021-2025 | |
| 22 | Carlos Martinez | 4 | 2016-2022 | |
| 22 | Enny Romero | 4 | 2012-2016 | |
| 22 | Michael Tonkin# | 4 | 2010-2017 | |
| 29 | Alex Colome | 3 | 2010-2022 | |
| 29 | Grant Dayton | 3 | 2012-2021 | |
| 29 | Greg Holland | 3 | 2012-2020 | |
| 29 | Raisel Iglesias# | 3 | 2016-2025 | |
| 29 | Joe Jimenez# | 3 | 2018-2025 | |
| 29 | Jake McGee | 3 | 2010-2022 | |
| 29 | Chris Perez | 3 | 2011-2015 | |
| 29 | Drew Pomeranz | 3 | 2012-2023 | |
| 29 | Ryan Pressly# | 3 | 2016-2025 | |
| 29 | Francisco Rodriguez | 3 | 2003-2018 | |
| 29 | Jordan Romano# | 3 | 2015-2025 | |
| 29 | Adam Wilk | 3 | 2010-2017 | |
| 29 | Devin Williams# | 3 | 2020-2025 | |
| 42 | Jose Alvarado# | 2 | 2018-2025 | |
| 42 | Scott Barlow# | 2 | 2020-2025 | |
| 42 | Cam Bedrosian | 2 | 2014-2021 | |
| 42 | Matt Brash# | 2 | 2024-2025 | |
| 42 | Maikel Cleto | 2 | 2010-2017 | |
| 42 | Keone Kela | 2 | 2016-2022 | |
| 42 | Luke Leftwich# | 2 | 2019-2021 | |
| 42 | Jonathan Loaisiga# | 2 | 2021-2025 | |
| 42 | Mark Melancon | 2 | 2010-2023 | |
| 42 | Matt Moore# | 2 | 2012-2025 | |
| 42 | Joe Musgrove# | 2 | 2012-2025 | |
| 42 | Vidal Nuno | 2 | 2010-2019 | |
| 42 | Glen Perkins | 2 | 2009-2018 | |
| 42 | David Robertson# | 2 | 2010-2025 | |
| 42 | Andres Santiago | 2 | 2010-2013 | |
| 42 | Joakim Soria | 2 | 2007-2020 | |
| 42 | Drew Storen | 2 | 2011-2018 | |
| 59 | Fernando Abad | 1 | 2012-2018 | |
| 59 | Yency Almonte# | 1 | 2019-2025 | |
| 59 | Johnny Antonelli | 1 | 1948-1961 | |
| 59 | Graham Ashcraft# | 1 | 2024-2025 | |
| 59 | John Axford | 1 | 2010-2017 | |
| 59 | Tanner Banks# | 1 | 2015-2025 | |
| 59 | David Bednar# | 1 | 2021-2025 | |
| 59 | Trevor Bettencourt | 1 | 2020-2021 | |
| 59 | Brett Bochy | 1 | 2012-2014 | |
| 59 | Nick Burdi# | 1 | 2015-2021 | |
| 59 | Joba Chamberlain | 1 | 2007-2017 | |
| 59 | Carl Edwards Jr.# | 1 | 2012-2024 | |
| 59 | Ryan Fernandez# | 1 | 2024-2024 | |
| 59 | Casey Fien | 1 | 2011-2017 | |
| 59 | Jaime Garcia | 1 | 2011-2017 | |
| 59 | Tanner Gordon# | 1 | 2025-2025 | |
| 59 | Steve Hamilton | 1 | 1961-1972 | |
| 59 | Kyle Harrison# | 1 | 2024-2025 | |
| 59 | Ryan Helsley# | 1 | 2020-2025 | |
| 59 | Blaine Howell | 1 | 2010-2012 | |
| 59 | Catfish Hunter | 1 | 1965-1976 | |
| 59 | Kenley Jansen# | 1 | 2012-2025 | |
| 59 | Nate Jones | 1 | 2010-2021 | |
| 59 | Yusei Kikuchi# | 1 | 2019-2025 | |
| 59 | Reynaldo Lopez# | 1 | 2020-2024 | |
| 59 | Wilton Lopez | 1 | 2012-2014 | |
| 59 | Daniel Lynch# | 1 | 2023-2025 | |
| 59 | Mason Miller# | 1 | 2024-2025 | |
| 59 | Andres Munoz# | 1 | 2021-2025 | |
| 59 | Colton Murray | 1 | 2012-2021 | |
| 59 | Packy Naughton# | 1 | 2023-2025 | |
| 59 | Ivan Nova | 1 | 2011-2021 | |
| 59 | Seung-hwan Oh | 1 | 2016-2019 | |
| 59 | Jonathan Papelbon | 1 | 2006-2017 | |
| 59 | Joel Peralta | 1 | 2005-2016 | |
| 59 | Wandy Peralta# | 1 | 2017-2025 | |
| 59 | Fernando Romero# | 1 | 2020-2023 | |
| 59 | Ricky Romero | 1 | 2010-2015 | |
| 59 | Hector Rondon | 1 | 2010-2021 | |
| 59 | Hyun-Jin Ryu | 1 | 2013-2023 | |
| 59 | Matt Shoemaker | 1 | 2015-2021 | |
| 59 | Lucas Sims# | 1 | 2019-2023 |
