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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | G | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Craig Kimbrel# | 33 | 2011-2025 | |
| 2 | Dellin Betances | 30 | 2011-2021 | |
| 3 | Darren O'Day | 27 | 2010-2022 | |
| 4 | Wade Davis | 25 | 2009-2020 | |
| 5 | Ryan Brasier# | 24 | 2010-2025 | |
| 5 | Jose Leclerc# | 24 | 2018-2025 | |
| 7 | Giovanny Gallegos# | 21 | 2018-2025 | |
| 7 | Andrew Kittredge# | 21 | 2019-2025 | |
| 7 | David Robertson# | 21 | 2010-2025 | |
| 7 | Justin Wilson | 21 | 2010-2021 | |
| 11 | David Price | 20 | 2009-2023 | |
| 11 | Justin Verlander# | 20 | 2007-2025 | |
| 13 | Aaron Nola# | 19 | 2015-2025 | |
| 13 | Tony Watson | 19 | 2011-2021 | |
| 15 | Peter Fairbanks# | 18 | 2020-2025 | |
| 15 | Taylor Rogers# | 18 | 2018-2025 | |
| 15 | Ryne Stanek# | 18 | 2017-2025 | |
| 18 | Aroldis Chapman# | 17 | 2011-2025 | |
| 18 | Josh Hader# | 17 | 2017-2025 | |
| 18 | Catfish Hunter | 17 | 1965-1976 | |
| 21 | Grant Dayton | 16 | 2012-2021 | |
| 21 | Michael Lorenzen# | 16 | 2018-2025 | |
| 21 | Chaz Roe | 16 | 2010-2021 | |
| 21 | Logan Webb# | 16 | 2015-2025 | |
| 25 | Archie Bradley | 15 | 2012-2022 | |
| 25 | Kenley Jansen# | 15 | 2012-2025 | |
| 25 | Mark Melancon | 15 | 2010-2023 | |
| 25 | Zach Putnam | 15 | 2010-2018 | |
| 25 | Alex Vesia# | 15 | 2020-2025 | |
| 30 | Jose Alvarado# | 14 | 2018-2025 | |
| 30 | Andrew Chafin# | 14 | 2012-2025 | |
| 30 | Ryan Helsley# | 14 | 2020-2025 | |
| 30 | Liam Hendriks# | 14 | 2012-2025 | |
| 30 | Clay Holmes# | 14 | 2012-2025 | |
| 30 | Keone Kela | 14 | 2016-2022 | |
| 30 | Clayton Kershaw# | 14 | 2009-2025 | |
| 30 | Dan Otero | 14 | 2010-2019 | |
| 30 | Adam Ottavino# | 14 | 2010-2024 | |
| 30 | Drew Pomeranz | 14 | 2012-2023 | |
| 30 | Max Scherzer# | 14 | 2009-2025 | |
| 30 | Garrett Whitlock# | 14 | 2021-2025 | |
| 30 | Brad Ziegler | 14 | 2007-2018 | |
| 43 | Gerrit Cole# | 13 | 2012-2025 | |
| 43 | Alex Colome | 13 | 2010-2022 | |
| 43 | Edwin Diaz# | 13 | 2017-2025 | |
| 43 | Luke Gregerson | 13 | 2010-2019 | |
| 43 | Oliver Perez | 13 | 2003-2022 | |
| 43 | Hector Rondon | 13 | 2010-2021 | |
| 43 | Jeffrey Springs# | 13 | 2021-2024 | |
| 43 | Zack Wheeler# | 13 | 2010-2025 | |
| 51 | Dan Altavilla# | 12 | 2015-2021 | |
| 51 | Scott Barlow# | 12 | 2020-2025 | |
| 51 | Sean Doolittle | 12 | 2011-2022 | |
| 51 | Carl Edwards Jr.# | 12 | 2012-2024 | |
| 51 | Luke Leftwich# | 12 | 2019-2021 | |
| 51 | Matt Moore# | 12 | 2012-2025 | |
| 51 | Colton Murray | 12 | 2012-2021 | |
| 51 | Jake Odorizzi | 12 | 2012-2023 | |
| 51 | Hyun-Jin Ryu | 12 | 2013-2023 | |
| 51 | Blake Treinen# | 12 | 2012-2025 | |
| 61 | Fernando Abad | 11 | 2012-2018 | |
| 61 | Nick Anderson# | 11 | 2020-2025 | |
| 61 | Madison Bumgarner | 11 | 2011-2023 | |
| 61 | Corbin Burnes# | 11 | 2020-2025 | |
| 61 | Carlos Carrasco | 11 | 2010-2023 | |
| 61 | Yu Darvish# | 11 | 2012-2025 | |
| 61 | Jacob Degrom# | 11 | 2012-2025 | |
| 61 | Steve Delabar | 11 | 2013-2017 | |
| 61 | Seranthony Dominguez# | 11 | 2019-2025 | |
| 61 | Tommy Hunter | 11 | 2010-2020 | |
| 61 | Carlos Martinez | 11 | 2016-2022 | |
| 61 | Lance McCullers Jr.# | 11 | 2016-2025 | |
| 61 | Jake McGee | 11 | 2010-2022 | |
| 61 | Miles Mikolas# | 11 | 2010-2025 | |
| 61 | Hoby Milner# | 11 | 2020-2024 | |
| 61 | Sam Moll# | 11 | 2024-2025 | |
| 61 | Charlie Morton# | 11 | 2010-2025 | |
| 61 | Shohei Ohtani# | 11 | 2018-2025 | |
| 61 | Chris Perez | 11 | 2011-2015 | |
| 61 | Ryan Pressly# | 11 | 2016-2025 | |
| 61 | Carlos Rodon# | 11 | 2015-2025 | |
| 61 | Bryan Shaw | 11 | 2012-2021 | |
| 61 | Joakim Soria | 11 | 2007-2020 | |
| 61 | Huston Street | 11 | 2005-2016 | |
| 61 | Marcus Stroman# | 11 | 2015-2024 | |
| 61 | Kirby Yates# | 11 | 2018-2025 | |
| 87 | Chad Bettis | 10 | 2012-2019 | |
| 87 | J.T. Chargois# | 10 | 2016-2023 | |
| 87 | Tyler Clippard | 10 | 2007-2019 | |
| 87 | Kevin Jepsen | 10 | 2010-2016 | |
| 87 | Jim Johnson | 10 | 2008-2018 | |
| 87 | Tyler Mahle# | 10 | 2017-2025 | |
| 87 | Kris Medlen | 10 | 2010-2016 | |
| 87 | Francisco Rodriguez | 10 | 2003-2018 | |
| 87 | Adam Wainwright | 10 | 2004-2023 | |
| 87 | Nick Wittgren# | 10 | 2016-2021 | |
| 97 | Scott Alexander# | 9 | 2012-2023 | |
| 97 | John Axford | 9 | 2010-2017 | |
| 97 | Grant Balfour | 9 | 2005-2014 | |
| 97 | Jacob Barnes# | 9 | 2012-2021 |
