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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Justin Verlander# | 122 | 2007-2025 | |
| 2 | Aaron Nola# | 108 | 2015-2025 | |
| 3 | David Price | 106 | 2009-2023 | |
| 4 | Clayton Kershaw# | 81 | 2009-2025 | |
| 5 | Jacob Degrom# | 79 | 2012-2025 | |
| 5 | Max Scherzer# | 79 | 2009-2025 | |
| 7 | Gerrit Cole# | 78 | 2012-2025 | |
| 7 | Zack Wheeler# | 78 | 2010-2025 | |
| 9 | Corbin Burnes# | 77 | 2020-2025 | |
| 10 | Madison Bumgarner | 73 | 2011-2023 | |
| 10 | Shohei Ohtani# | 73 | 2018-2025 | |
| 12 | Stephen Strasburg# | 70 | 2010-2025 | |
| 13 | Dellin Betances | 66 | 2011-2021 | |
| 13 | Blake Snell# | 66 | 2012-2025 | |
| 15 | Walker Buehler# | 63 | 2019-2025 | |
| 16 | Sandy Koufax | 61 | 1955-1966 | |
| 17 | Catfish Hunter | 59 | 1965-1976 | |
| 18 | Lance McCullers Jr.# | 57 | 2016-2025 | |
| 19 | Carlos Carrasco | 55 | 2010-2023 | |
| 20 | Yu Darvish# | 54 | 2012-2025 | |
| 21 | Craig Kimbrel# | 53 | 2011-2025 | |
| 21 | Marcus Stroman# | 53 | 2015-2024 | |
| 21 | Adam Wainwright | 53 | 2004-2023 | |
| 24 | Wade Davis | 52 | 2009-2020 | |
| 24 | Carlos Rodon# | 52 | 2015-2025 | |
| 26 | Corey Kluber | 48 | 2011-2023 | |
| 26 | Pablo Lopez# | 48 | 2021-2025 | |
| 28 | Nathan Eovaldi# | 43 | 2012-2025 | |
| 29 | Jeurys Familia | 42 | 2010-2022 | |
| 29 | Tyler Mahle# | 42 | 2017-2025 | |
| 29 | Smith Smith | 42 | 2004-2017 | |
| 32 | Johnny Cueto | 41 | 2010-2023 | |
| 33 | Gio Gonzalez | 40 | 2010-2022 | |
| 33 | Mat Latos | 40 | 2010-2016 | |
| 33 | Matt Moore# | 40 | 2012-2025 | |
| 33 | Jake Odorizzi | 40 | 2012-2023 | |
| 33 | Edinson Volquez | 40 | 2008-2020 | |
| 38 | Justin Wilson | 39 | 2010-2021 | |
| 39 | Jose Leclerc# | 38 | 2018-2025 | |
| 39 | Charlie Morton# | 38 | 2010-2025 | |
| 41 | Trevor Bauer | 37 | 2012-2023 | |
| 41 | Jon Niese | 37 | 2009-2016 | |
| 43 | Ryan Helsley# | 36 | 2020-2025 | |
| 44 | Merrill Kelly# | 35 | 2019-2024 | |
| 44 | German Marquez# | 35 | 2018-2025 | |
| 44 | Freddy Peralta# | 35 | 2019-2025 | |
| 47 | Chris Archer | 34 | 2012-2023 | |
| 47 | Derek Holland | 34 | 2010-2019 | |
| 49 | Miles Mikolas# | 32 | 2010-2025 | |
| 49 | David Robertson# | 32 | 2010-2025 | |
| 51 | Giovanny Gallegos# | 31 | 2018-2025 | |
| 51 | Jaime Garcia | 31 | 2011-2017 | |
| 51 | Michael Pineda | 31 | 2011-2023 | |
| 51 | Jose Quintana# | 31 | 2013-2025 | |
| 55 | Chad Bettis | 30 | 2012-2019 | |
| 55 | Christian Friedrich | 30 | 2010-2022 | |
| 55 | Matt Harvey | 30 | 2014-2021 | |
| 55 | Shane McClanahan# | 30 | 2023-2025 | |
| 55 | Jose Junior Rosario | 30 | 2012-2017 | |
| 55 | Hyun-Jin Ryu | 30 | 2013-2023 | |
| 55 | Julio Urias# | 30 | 2018-2023 | |
| 62 | Aroldis Chapman# | 29 | 2011-2025 | |
| 62 | Darren O'Day | 29 | 2010-2022 | |
| 62 | Patrick Sandoval# | 29 | 2021-2025 | |
| 65 | Homer Bailey | 28 | 2009-2020 | |
| 65 | Dylan Cease# | 28 | 2015-2025 | |
| 65 | Lucas Giolito# | 28 | 2016-2025 | |
| 65 | Robbie Ray# | 28 | 2017-2025 | |
| 69 | Tarik Skubal# | 27 | 2022-2025 | |
| 69 | Smith Smith | 27 | 2006-2020 | |
| 71 | Grant Dayton | 26 | 2012-2021 | |
| 71 | Kevin Gausman# | 26 | 2013-2025 | |
| 71 | Kyle Hendricks# | 26 | 2016-2024 | |
| 71 | Collin McHugh | 26 | 2010-2024 | |
| 71 | Shelby Miller# | 26 | 2012-2023 | |
| 71 | Ryan Pressley | 26 | 2010-2012 | |
| 71 | Justin Steele# | 26 | 2015-2025 | |
| 78 | Tyler Glasnow# | 25 | 2017-2025 | |
| 78 | Alex Vesia# | 25 | 2020-2025 | |
| 80 | Ryan Brasier# | 24 | 2010-2025 | |
| 80 | Erik Davis | 24 | 2010-2015 | |
| 80 | Cole Hamels | 24 | 2007-2022 | |
| 80 | Chris Jones | 24 | 2010-2012 | |
| 80 | Matt Manning# | 24 | 2021-2025 | |
| 80 | Chris Paddack# | 24 | 2020-2025 | |
| 80 | Chris Perez | 24 | 2011-2015 | |
| 80 | Chris Sale# | 24 | 2011-2024 | |
| 88 | Edwin Diaz# | 23 | 2017-2025 | |
| 88 | Jon Lester | 23 | 2007-2021 | |
| 88 | Joe Musgrove# | 23 | 2012-2025 | |
| 88 | James Paxton# | 23 | 2014-2024 | |
| 88 | Wily Peralta | 23 | 2012-2019 | |
| 93 | Matthew Boyd# | 22 | 2019-2025 | |
| 93 | Steve Delabar | 22 | 2013-2017 | |
| 93 | Josh Hader# | 22 | 2017-2025 | |
| 93 | Felix Hernandez | 22 | 2005-2021 | |
| 93 | Bryse Wilson# | 22 | 2020-2025 | |
| 98 | Matt Cain | 21 | 2006-2019 | |
| 98 | Maikel Cleto | 21 | 2010-2017 | |
| 98 | Peter Fairbanks# | 21 | 2020-2025 |
