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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | OOPS | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Chris Jones | .3580 | 2010-2012 | |
| 2 | Kyle Hendricks# | .4128 | 2016-2024 | |
| 3 | Sandy Koufax | .4307 | 1955-1966 | |
| 4 | Justin Souza | .4342 | 2012-2012 | |
| 5 | Jacob Degrom# | .4895 | 2012-2025 | |
| 6 | Mat Latos | .5271 | 2010-2016 | |
| 7 | Jon Niese | .5387 | 2009-2016 | |
| 8 | Stephen Strasburg# | .5654 | 2010-2025 | |
| 9 | Shane McClanahan# | .5686 | 2023-2025 | |
| 10 | Cole Hamels | .5716 | 2007-2022 | |
| 11 | Madison Bumgarner | .5804 | 2011-2023 | |
| 12 | Catfish Hunter | .5897 | 1965-1976 | |
| 13 | Merrill Kelly# | .5910 | 2019-2024 | |
| 14 | Lance McCullers Jr.# | .5917 | 2016-2025 | |
| 15 | Yu Darvish# | .5937 | 2012-2025 | |
| 16 | Craig Kimbrel# | .5960 | 2011-2025 | |
| 17 | Chris Archer | .6066 | 2012-2023 | |
| 18 | Corbin Burnes# | .6091 | 2020-2025 | |
| 19 | Carlos Carrasco | .6251 | 2010-2023 | |
| 20 | Homer Bailey | .6284 | 2009-2020 | |
| 21 | Blake Snell# | .6295 | 2012-2025 | |
| 22 | Michael Pineda | .6297 | 2011-2023 | |
| 23 | Gerrit Cole# | .6314 | 2012-2025 | |
| 24 | Gio Gonzalez | .6357 | 2010-2022 | |
| 25 | Jeurys Familia | .6381 | 2010-2022 | |
| 26 | Dellin Betances | .6419 | 2011-2021 | |
| 27 | Justin Verlander# | .6435 | 2007-2025 | |
| 28 | Nathan Eovaldi# | .6511 | 2012-2025 | |
| 29 | Trevor Bauer | .6727 | 2012-2023 | |
| 30 | Jose Quintana# | .6829 | 2013-2025 | |
| 31 | Charlie Morton# | .6910 | 2010-2025 | |
| 32 | Max Scherzer# | .6916 | 2009-2025 | |
| 33 | Shohei Ohtani# | .7047 | 2018-2025 | |
| 34 | Aaron Nola# | .7118 | 2015-2025 | |
| 35 | German Marquez# | .7161 | 2018-2025 | |
| 36 | Adam Wainwright | .7164 | 2004-2023 | |
| 37 | Derek Holland | .7183 | 2010-2019 | |
| 38 | Walker Buehler# | .7187 | 2019-2025 | |
| 39 | Chad Bettis | .7193 | 2012-2019 | |
| 40 | Zack Wheeler# | .7230 | 2010-2025 | |
| 41 | Smith Smith | .7258 | 2004-2017 | |
| 42 | Corey Kluber | .7286 | 2011-2023 | |
| 43 | David Price | .7411 | 2009-2023 | |
| 44 | Johnny Cueto | .7504 | 2010-2023 | |
| 45 | Jake Odorizzi | .7511 | 2012-2023 | |
| 46 | Tyler Mahle# | .7539 | 2017-2025 | |
| 47 | Wade Davis | .7559 | 2009-2020 | |
| 48 | Edinson Volquez | .7582 | 2008-2020 | |
| 49 | Clayton Kershaw# | .7591 | 2009-2025 | |
| 50 | Matt Moore# | .7635 | 2012-2025 | |
| 51 | Dylan Cease# | .7653 | 2015-2025 | |
| 52 | Jaime Garcia | .7757 | 2011-2017 | |
| 53 | Ross Detwiler | .7903 | 2011-2023 | |
| 54 | Ryan Pressley | .7946 | 2010-2012 | |
| 55 | Freddy Peralta# | .7951 | 2019-2025 | |
| 56 | Marcus Stroman# | .8024 | 2015-2024 | |
| 57 | Carlos Rodon# | .8270 | 2015-2025 | |
| 58 | Hyun-Jin Ryu | .8335 | 2013-2023 | |
| 59 | Pablo Lopez# | .8503 | 2021-2025 | |
| 60 | Miles Mikolas# | .8553 | 2010-2025 | |
| 61 | Logan Webb# | .8747 | 2015-2025 | |
| 62 | Matthew Boyd# | .8889 | 2019-2025 | |
| 63 | Julio Urias# | .8951 | 2018-2023 |
