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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | IP | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Zack Greinke# | 3387.0 | 2005-2023 | |
| 2 | CC Sabathia | 3197.0 | 2002-2020 | |
| 3 | Catfish Hunter | 3083.0 | 1965-1976 | |
| 4 | Adam Wainwright# | 2884.0 | 2004-2023 | |
| 5 | Smith Smith | 2804.0 | 2002-2017 | |
| 6 | Felix Hernandez | 2746.0 | 2005-2021 | |
| 7 | Bartolo Colon | 2670.0 | 1997-2019 | |
| 8 | Clayton Kershaw# | 2602.0 | 2009-2023 | |
| 8 | Justin Verlander# | 2602.0 | 2007-2023 | |
| 10 | Cole Hamels | 2545.0 | 2007-2022 | |
| 11 | Jake Peavy | 2521.0 | 2002-2018 | |
| 12 | John Lackey | 2506.0 | 2003-2017 | |
| 13 | Smith Smith | 2450.0 | 2006-2020 | |
| 14 | Max Scherzer# | 2355.0 | 2009-2023 | |
| 15 | Johnny Cueto# | 2348.0 | 2010-2023 | |
| 16 | Jon Lester | 2339.0 | 2007-2021 | |
| 17 | Sandy Koufax | 2324.0 | 1955-1966 | |
| 18 | Josh M. Johnson | 2305.0 | 2006-2017 | |
| 19 | Larry Dierker | 2294.0 | 1964-1976 | |
| 20 | Scott Kazmir | 2256.0 | 2005-2018 | |
| 21 | J.J. Franco | 2213.0 | 1999-2014 | |
| 22 | Aaron Harang | 2172.0 | 2002-2015 | |
| 23 | Smith Smith | 2137.0 | 2004-2017 | |
| 24 | Lance Lynn# | 2131.0 | 2010-2023 | |
| 25 | Michael Pineda# | 2101.0 | 2011-2023 | |
| 26 | David Price# | 2095.0 | 2009-2023 | |
| 27 | Anibal Sanchez | 2039.0 | 2007-2021 | |
| 28 | Matt Cain | 2038.0 | 2006-2019 | |
| 29 | Johnny Antonelli | 1992.0 | 1948-1961 | |
| 30 | James Shields | 1988.0 | 2007-2019 | |
| 31 | Brandon McCarthy | 1959.0 | 2006-2019 | |
| 32 | Charlie Morton# | 1942.0 | 2010-2023 | |
| 33 | Bob Feller | 1935.0 | 1947-1956 | |
| 34 | Rich Hill# | 1909.0 | 2006-2023 | |
| 35 | Jered Weaver | 1887.0 | 2007-2017 | |
| 36 | Brett Anderson | 1881.0 | 2010-2021 | |
| 37 | Jordan Zimmermann | 1880.0 | 2010-2021 | |
| 38 | Stephen Strasburg# | 1871.0 | 2010-2023 | |
| 39 | Zack Wheeler# | 1866.0 | 2010-2023 | |
| 40 | Brett Myers | 1847.0 | 2003-2014 | |
| 41 | Jake Arrieta | 1835.0 | 2011-2022 | |
| 42 | Billy O'Dell | 1817.0 | 1954-1967 | |
| 43 | Pat Corbin# | 1792.0 | 2010-2023 | |
| 44 | Yu Darvish# | 1781.0 | 2012-2023 | |
| 45 | Chris Sale# | 1777.0 | 2011-2023 | |
| 46 | Clay Buchholz | 1774.0 | 2008-2020 | |
| 47 | Madison Bumgarner# | 1773.0 | 2011-2023 | |
| 48 | Gio Gonzalez | 1762.0 | 2010-2022 | |
| 49 | Jose Quintana# | 1760.0 | 2013-2023 | |
| 50 | Edinson Volquez | 1753.0 | 2008-2020 | |
| 51 | James Happ | 1737.0 | 2009-2022 | |
| 52 | Dallas Keuchel | 1709.0 | 2010-2022 | |
| 53 | Ricky Nolasco | 1705.0 | 2007-2017 | |
| 54 | Alex Wood# | 1704.0 | 2014-2023 | |
| 55 | John Danks | 1686.0 | 2008-2018 | |
| 56 | Ervin Santana | 1670.0 | 2002-2019 | |
| 57 | Julio Teheran# | 1660.0 | 2011-2022 | |
| 58 | Kevin Gausman# | 1624.0 | 2013-2023 | |
| 59 | Alex Cobb# | 1617.0 | 2012-2023 | |
| 60 | Chris Young | 1615.0 | 2004-2016 | |
| 61 | Ian Kennedy# | 1605.0 | 2010-2022 | |
| 62 | Gerrit Cole# | 1599.0 | 2012-2023 | |
| 63 | Rick Porcello | 1598.0 | 2011-2021 | |
| 64 | Jeff Samardzija | 1586.0 | 2010-2020 | |
| 65 | Mike Minor# | 1537.0 | 2010-2023 | |
| 66 | Phil Hughes | 1527.0 | 2009-2018 | |
| 67 | Wade Miley# | 1526.0 | 2010-2023 | |
| 68 | Paul Maholm | 1523.0 | 2006-2015 | |
| 69 | Nathan Eovaldi# | 1515.0 | 2012-2023 | |
| 70 | Masahiro Tanaka | 1508.0 | 2014-2021 | |
| 71 | Gavin Floyd | 1505.0 | 2005-2017 | |
| 72 | Chris Archer | 1504.0 | 2012-2023 | |
| 73 | Noah Syndergaard# | 1503.0 | 2016-2023 | |
| 74 | Carlos Carrasco# | 1499.0 | 2010-2023 | |
| 75 | Hyun-Jin Ryu# | 1472.0 | 2013-2023 | |
| 76 | Homer Bailey | 1469.0 | 2009-2020 | |
| 77 | Jon Gray# | 1462.0 | 2015-2023 | |
| 78 | Danny Salazar | 1455.0 | 2010-2021 | |
| 79 | Kyle Gibson# | 1452.0 | 2010-2023 | |
| 80 | Michael Wacha# | 1449.0 | 2015-2023 | |
| 81 | Dylan Bundy# | 1440.0 | 2012-2023 | |
| 82 | Danny Duffy | 1433.0 | 2012-2022 | |
| 83 | Jason Hammel | 1429.0 | 2008-2018 | |
| 84 | Garrett Richards# | 1423.0 | 2012-2022 | |
| 85 | Jameson Taillon# | 1421.0 | 2014-2023 | |
| 86 | Corey Kluber# | 1419.0 | 2011-2023 | |
| 87 | Chad Billingsley | 1415.0 | 2007-2015 | |
| 88 | Matt Moore# | 1414.0 | 2012-2023 | |
| 89 | Smith Smith | 1401.0 | 2008-2017 | |
| 90 | James Paxton# | 1393.0 | 2014-2023 | |
| 91 | Tim Lincecum | 1385.0 | 2009-2018 | |
| 91 | Marcus Stroman# | 1385.0 | 2015-2023 | |
| 91 | Jacob Degrom# | 1385.0 | 2012-2023 | |
| 94 | Matt Garza | 1370.0 | 2009-2017 | |
| 95 | Matt Harvey | 1363.0 | 2014-2021 | |
| 96 | Rich Harden | 1362.0 | 2004-2013 | |
| 97 | Derek Holland | 1361.0 | 2010-2019 | |
| 98 | Ivan Nova | 1345.0 | 2011-2021 | |
| 99 | Kyle Hendricks# | 1343.0 | 2016-2023 | |
| 100 | Yovani Gallardo | 1320.0 | 2008-2018 |
