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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Clayton Kershaw# | 2995 | 2009-2025 | |
| 2 | Justin Verlander# | 2860 | 2007-2025 | |
| 3 | Max Scherzer# | 2851 | 2009-2025 | |
| 4 | CC Sabathia | 2824 | 2002-2020 | |
| 5 | Felix Hernandez | 2786 | 2005-2021 | |
| 6 | Smith Smith | 2617 | 2006-2020 | |
| 7 | Jake Peavy | 2578 | 2002-2018 | |
| 8 | Cole Hamels | 2566 | 2007-2022 | |
| 9 | Sandy Koufax | 2396 | 1955-1966 | |
| 10 | Adam Wainwright | 2357 | 2004-2023 | |
| 11 | Stephen Strasburg# | 2348 | 2010-2025 | |
| 12 | Jon Lester | 2260 | 2007-2021 | |
| 13 | Scott Kazmir | 2213 | 2005-2018 | |
| 14 | Lance Lynn# | 2210 | 2010-2025 | |
| 15 | John Lackey | 2154 | 2003-2017 | |
| 16 | Josh M. Johnson | 2099 | 2006-2017 | |
| 17 | Yu Darvish# | 2078 | 2012-2025 | |
| 18 | David Price | 2063 | 2009-2023 | |
| 19 | Bartolo Colon | 2060 | 1997-2019 | |
| 20 | Smith Smith | 2054 | 2004-2017 | |
| 21 | Chris Sale# | 2040 | 2011-2024 | |
| 22 | Zack Wheeler# | 2014 | 2010-2025 | |
| 23 | Johnny Cueto | 2011 | 2010-2023 | |
| 24 | Gerrit Cole# | 2001 | 2012-2025 | |
| 25 | J.J. Franco | 1998 | 1999-2014 | |
| 26 | Anibal Sanchez | 1973 | 2007-2021 | |
| 27 | Charlie Morton# | 1912 | 2010-2025 | |
| 28 | Catfish Hunter | 1870 | 1965-1976 | |
| 29 | Michael Pineda | 1848 | 2011-2023 | |
| 30 | Matt Cain | 1847 | 2006-2019 | |
| 31 | Aaron Harang | 1811 | 2002-2015 | |
| 32 | James Shields | 1798 | 2007-2019 | |
| 33 | Edinson Volquez | 1784 | 2008-2020 | |
| 34 | Kevin Gausman# | 1778 | 2013-2025 | |
| 34 | Rich Hill# | 1778 | 2006-2023 | |
| 36 | Gio Gonzalez | 1766 | 2010-2022 | |
| 37 | Jered Weaver | 1738 | 2007-2017 | |
| 38 | Smith Smith | 1732 | 2002-2017 | |
| 39 | Jake Arrieta | 1695 | 2011-2022 | |
| 40 | Brett Myers | 1675 | 2003-2014 | |
| 41 | Jacob Degrom# | 1673 | 2012-2025 | |
| 42 | Lance McCullers Jr.# | 1648 | 2016-2025 | |
| 43 | James Happ | 1613 | 2009-2022 | |
| 44 | Tim Lincecum | 1611 | 2009-2018 | |
| 45 | Jose Quintana# | 1594 | 2013-2025 | |
| 46 | Madison Bumgarner | 1585 | 2011-2023 | |
| 47 | Clay Buchholz | 1570 | 2008-2020 | |
| 48 | Jordan Zimmermann | 1567 | 2010-2021 | |
| 49 | Ian Kennedy | 1566 | 2010-2022 | |
| 50 | Chris Archer | 1562 | 2012-2023 | |
| 51 | Matt Moore# | 1555 | 2012-2025 | |
| 52 | Jon Gray# | 1548 | 2015-2025 | |
| 53 | Brandon McCarthy | 1537 | 2006-2019 | |
| 54 | Julio Teheran | 1532 | 2011-2022 | |
| 55 | Chris Young | 1520 | 2004-2016 | |
| 56 | Nathan Eovaldi# | 1511 | 2012-2025 | |
| 57 | Ricky Nolasco | 1500 | 2007-2017 | |
| 58 | Alex Cobb# | 1493 | 2012-2025 | |
| 59 | Larry Dierker | 1487 | 1964-1976 | |
| 60 | Oliver Perez | 1474 | 2003-2022 | |
| 60 | Jeff Samardzija | 1474 | 2010-2020 | |
| 62 | Jameson Taillon# | 1444 | 2014-2025 | |
| 63 | Phil Hughes | 1434 | 2009-2018 | |
| 64 | James Paxton# | 1427 | 2014-2024 | |
| 65 | Chad Billingsley | 1426 | 2007-2015 | |
| 66 | Brett Anderson | 1423 | 2010-2021 | |
| 67 | Masahiro Tanaka | 1412 | 2014-2021 | |
| 68 | Ervin Santana | 1402 | 2002-2019 | |
| 69 | John Danks | 1399 | 2008-2018 | |
| 70 | Brandon Morrow | 1396 | 2009-2020 | |
| 71 | Mike Minor | 1395 | 2010-2023 | |
| 71 | Danny Salazar | 1395 | 2010-2021 | |
| 71 | Blake Snell# | 1395 | 2012-2025 | |
| 74 | Michael Wacha# | 1388 | 2015-2025 | |
| 75 | Lucas Giolito# | 1384 | 2016-2025 | |
| 76 | Rich Harden | 1383 | 2004-2013 | |
| 77 | Sonny Gray# | 1381 | 2012-2025 | |
| 78 | Aroldis Chapman# | 1369 | 2011-2025 | |
| 79 | Matt Garza | 1354 | 2009-2017 | |
| 80 | Tyler Mahle# | 1353 | 2017-2025 | |
| 80 | Luis Severino# | 1353 | 2016-2025 | |
| 82 | Carlos Carrasco | 1342 | 2010-2023 | |
| 83 | Brandon Woodruff# | 1310 | 2015-2025 | |
| 84 | Craig Kimbrel# | 1307 | 2011-2025 | |
| 84 | Smith Smith | 1307 | 2008-2017 | |
| 86 | Ubaldo Jimenez | 1306 | 2010-2020 | |
| 87 | Hyun-Jin Ryu | 1303 | 2013-2023 | |
| 88 | Rick Porcello | 1294 | 2011-2021 | |
| 89 | Dylan Bundy | 1290 | 2012-2023 | |
| 90 | Aaron Nola# | 1286 | 2015-2025 | |
| 91 | Matt Harvey | 1284 | 2014-2021 | |
| 91 | Corey Kluber | 1284 | 2011-2023 | |
| 93 | Collin McHugh | 1260 | 2010-2024 | |
| 94 | Yovani Gallardo | 1257 | 2008-2018 | |
| 95 | Ryan Madson | 1256 | 2003-2019 | |
| 96 | Gavin Floyd | 1247 | 2005-2017 | |
| 96 | Tyler Glasnow# | 1247 | 2017-2025 | |
| 98 | Danny Duffy | 1239 | 2012-2022 | |
| 99 | Robbie Ray# | 1228 | 2017-2025 | |
| 99 | Garrett Richards | 1228 | 2012-2022 |
