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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Sandy Koufax | 382 | 1965 | |
| 2 | Yu Darvish# | 327 | 2014 | |
| 3 | Sandy Koufax | 317 | 1966 | |
| 3 | Yu Darvish# | 317 | 2015 | |
| 5 | Stephen Strasburg | 308 | 2014 | |
| 6 | Sandy Koufax | 306 | 1963 | |
| 7 | David Price | 300 | 2015 | |
| 8 | Justin Verlander# | 299 | 2020 | |
| 9 | Stephen Strasburg | 292 | 2013 | |
| 10 | Tim Lincecum | 291 | 2011 | |
| 10 | Clayton Kershaw# | 291 | 2015 | |
| 12 | Felix Hernandez | 290 | 2014 | |
| 13 | J.J. Franco | 287 | 2004 | |
| 14 | Smith Smith | 286 | 2014 | |
| 14 | Jon Lester | 286 | 2015 | |
| 16 | Stephen Strasburg | 283 | 2016 | |
| 17 | Felix Hernandez | 276 | 2015 | |
| 17 | Max Scherzer# | 276 | 2015 | |
| 17 | Spencer Strider# | 276 | 2024 | |
| 20 | Smith Smith | 275 | 2015 | |
| 20 | Tim Lincecum | 275 | 2010 | |
| 22 | Jacob Degrom# | 273 | 2025 | |
| 22 | Chris Sale# | 273 | 2016 | |
| 24 | Yu Darvish# | 272 | 2013 | |
| 24 | Smith Smith | 272 | 2014 | |
| 26 | Sandy Koufax | 269 | 1961 | |
| 27 | Bartolo Colon | 264 | 2001 | |
| 28 | Clayton Kershaw# | 262 | 2018 | |
| 28 | Stephen Strasburg | 262 | 2012 | |
| 28 | Gerrit Cole# | 262 | 2020 | |
| 28 | Cole Hamels | 262 | 2013 | |
| 28 | Tyler Glasnow# | 262 | 2022 | |
| 33 | Yu Darvish# | 260 | 2016 | |
| 33 | Felix Hernandez | 260 | 2016 | |
| 35 | Mat Latos | 258 | 2015 | |
| 35 | Tim Lincecum | 258 | 2013 | |
| 37 | Clayton Kershaw# | 257 | 2014 | |
| 38 | Smith Smith | 256 | 2013 | |
| 38 | Max Scherzer# | 256 | 2014 | |
| 40 | David Price | 254 | 2014 | |
| 40 | CC Sabathia | 254 | 2013 | |
| 42 | Oliver Perez | 253 | 2005 | |
| 42 | Matt Harvey | 253 | 2015 | |
| 44 | Edinson Volquez | 252 | 2013 | |
| 44 | Cole Ragans# | 252 | 2026 | |
| 46 | Clayton Kershaw# | 250 | 2013 | |
| 47 | Edwin Jackson | 249 | 2004 | |
| 47 | Tarik Skubal# | 249 | 2026 | |
| 47 | Gerrit Cole# | 249 | 2021 | |
| 47 | Tim Lincecum | 249 | 2012 | |
| 51 | Derek Holland | 248 | 2014 | |
| 51 | Lucas Giolito# | 248 | 2022 | |
| 53 | Spencer Strider# | 247 | 2025 | |
| 53 | Jacob Degrom# | 247 | 2017 | |
| 53 | Mat Latos | 247 | 2013 | |
| 53 | Jake Peavy | 247 | 2006 | |
| 57 | Anibal Sanchez | 246 | 2014 | |
| 57 | Chad Billingsley | 246 | 2013 | |
| 57 | Patrick Corbin# | 246 | 2018 | |
| 60 | A.J. Griffin | 245 | 2015 | |
| 61 | Matt Moore# | 244 | 2014 | |
| 61 | Jered Weaver | 244 | 2013 | |
| 61 | Andrew Heaney# | 244 | 2020 | |
| 64 | Max Scherzer# | 243 | 2017 | |
| 64 | Felix Hernandez | 243 | 2011 | |
| 64 | Luis Severino# | 243 | 2020 | |
| 64 | Yovani Gallardo | 243 | 2012 | |
| 68 | Ryan Madson | 242 | 2004 | |
| 68 | Scott Kazmir | 242 | 2016 | |
| 70 | Rich Harden | 241 | 2010 | |
| 71 | Jacob Degrom# | 240 | 2024 | |
| 71 | Jon Lester | 240 | 2014 | |
| 71 | Felix Hernandez | 240 | 2013 | |
| 74 | Lucas Giolito# | 239 | 2020 | |
| 74 | Matt Cain | 239 | 2012 | |
| 74 | Roki Sasaki# | 239 | 2025 | |
| 74 | Max Scherzer# | 239 | 2020 | |
| 74 | Gio Gonzalez | 239 | 2014 | |
| 74 | Cole Hamels | 239 | 2014 | |
| 74 | Josh M. Johnson | 239 | 2012 | |
| 81 | Matt Cain | 238 | 2015 | |
| 81 | Patrick Corbin# | 238 | 2019 | |
| 81 | Chris Tillman | 238 | 2015 | |
| 81 | Hyun-Jin Ryu | 238 | 2015 | |
| 85 | Gio Gonzalez | 237 | 2015 | |
| 85 | CC Sabathia | 237 | 2010 | |
| 85 | Garrett Crochet# | 237 | 2026 | |
| 85 | Justin Verlander# | 237 | 2022 | |
| 85 | David Price | 237 | 2013 | |
| 85 | Cole Hamels | 237 | 2015 | |
| 91 | Josh M. Johnson | 236 | 2013 | |
| 91 | Chris Tillman | 236 | 2014 | |
| 93 | Paul Skenes# | 235 | 2026 | |
| 93 | Corey Kluber | 235 | 2017 | |
| 95 | Clayton Kershaw# | 234 | 2017 | |
| 96 | Smith Smith | 233 | 2013 | |
| 96 | Ian Kennedy | 233 | 2014 | |
| 96 | Tatsuya Imai# | 233 | 2026 | |
| 96 | Blake Snell# | 233 | 2023 | |
| 100 | Felix Hernandez | 232 | 2012 |
