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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K9 | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Aroldis Chapman# | 13.68 | 2011-2025 | |
| 2 | Craig Kimbrel# | 13.21 | 2011-2025 | |
| 3 | Trevor Rosenthal | 12.15 | 2010-2023 | |
| 4 | Pedro Strop | 12.02 | 2011-2021 | |
| 5 | Tyler Clippard | 11.88 | 2007-2019 | |
| 6 | Joe Nathan | 11.74 | 2000-2016 | |
| 7 | David Robertson# | 11.62 | 2010-2025 | |
| 8 | Kenley Jansen# | 11.49 | 2012-2025 | |
| 8 | Jonathan Broxton | 11.49 | 2007-2017 | |
| 10 | Darren O'Day | 11.41 | 2010-2022 | |
| 10 | Sean Doolittle | 11.41 | 2011-2022 | |
| 12 | Francisco Rodriguez | 11.22 | 2003-2018 | |
| 13 | Steve Cishek | 10.88 | 2012-2021 | |
| 14 | Rafael Soriano | 10.84 | 2003-2015 | |
| 14 | Huston Street | 10.84 | 2005-2016 | |
| 16 | Jonathan Papelbon | 10.80 | 2006-2017 | |
| 17 | Sergio Romo | 10.71 | 2010-2021 | |
| 18 | Koji Uehara | 10.54 | 2009-2018 | |
| 19 | Caleb Ferguson# | 10.49 | 2015-2025 | |
| 20 | Tim Lincecum | 10.47 | 2009-2018 | |
| 21 | Adam Ottavino# | 10.41 | 2010-2024 | |
| 22 | Tyler Glasnow# | 10.40 | 2017-2025 | |
| 22 | Matt Strahm# | 10.40 | 2016-2025 | |
| 24 | Smith Smith | 10.32 | 2005-2014 | |
| 25 | Smith Smith | 10.27 | 2002-2018 | |
| 26 | Fernando Rodney | 10.24 | 2005-2018 | |
| 27 | Luke Gregerson | 10.22 | 2010-2019 | |
| 28 | Jake McGee | 10.19 | 2010-2022 | |
| 29 | Yu Darvish# | 10.11 | 2012-2025 | |
| 30 | Raisel Iglesias# | 10.09 | 2016-2025 | |
| 30 | Joakim Soria | 10.09 | 2007-2020 | |
| 32 | Oliver Perez | 10.07 | 2003-2022 | |
| 33 | Max Scherzer# | 10.05 | 2009-2025 | |
| 34 | Jeurys Familia | 9.98 | 2010-2022 | |
| 34 | Hector Rondon | 9.98 | 2010-2021 | |
| 36 | Robbie Ray# | 9.97 | 2017-2025 | |
| 37 | Brandon Morrow | 9.90 | 2009-2020 | |
| 38 | Freddy Peralta# | 9.86 | 2019-2025 | |
| 39 | Blake Snell# | 9.81 | 2012-2025 | |
| 40 | Juan Nicasio | 9.79 | 2010-2019 | |
| 41 | Trevor Bauer | 9.77 | 2012-2023 | |
| 42 | Mat Latos | 9.76 | 2010-2016 | |
| 43 | Jesse Crain | 9.67 | 2006-2015 | |
| 44 | Chris Sale# | 9.65 | 2011-2025 | |
| 45 | Stephen Strasburg# | 9.62 | 2010-2025 | |
| 46 | Smith Smith | 9.61 | 2006-2020 | |
| 47 | Andrew Miller | 9.58 | 2007-2020 | |
| 48 | Clayton Kershaw# | 9.57 | 2009-2025 | |
| 49 | Santiago Casilla | 9.54 | 2005-2017 | |
| 50 | Jarrod Parker | 9.52 | 2012-2015 | |
| 50 | Liam Hendriks# | 9.52 | 2012-2025 | |
| 52 | Mark Melancon | 9.49 | 2010-2023 | |
| 52 | Gerrit Cole# | 9.49 | 2012-2025 | |
| 54 | Shohei Ohtani# | 9.48 | 2018-2025 | |
| 55 | Drew Pomeranz | 9.45 | 2012-2023 | |
| 55 | Neal Cotts | 9.45 | 2005-2016 | |
| 57 | Yusei Kikuchi# | 9.35 | 2019-2025 | |
| 58 | Chris Archer | 9.34 | 2012-2023 | |
| 58 | Shelby Miller# | 9.34 | 2012-2023 | |
| 58 | Lance McCullers Jr.# | 9.34 | 2016-2025 | |
| 61 | Kris Medlen | 9.30 | 2010-2016 | |
| 62 | Alex Colome | 9.28 | 2010-2022 | |
| 62 | Sandy Koufax | 9.28 | 1955-1966 | |
| 64 | Justin Verlander# | 9.24 | 2007-2025 | |
| 65 | J.P. Howell | 9.22 | 2008-2017 | |
| 66 | Neftali Feliz | 9.21 | 2010-2018 | |
| 67 | Jake Peavy | 9.20 | 2002-2018 | |
| 68 | Lucas Giolito# | 9.19 | 2016-2025 | |
| 69 | Jose De Leon# | 9.18 | 2017-2022 | |
| 70 | Chris Tillman | 9.17 | 2010-2020 | |
| 70 | Jacob Degrom# | 9.17 | 2012-2025 | |
| 72 | Wade Davis | 9.16 | 2009-2020 | |
| 72 | Edinson Volquez | 9.16 | 2008-2020 | |
| 74 | Rich Harden | 9.14 | 2004-2013 | |
| 75 | Felix Hernandez | 9.13 | 2005-2021 | |
| 76 | Manny Parra | 9.12 | 2007-2016 | |
| 77 | Dylan Cease# | 9.11 | 2015-2025 | |
| 77 | Jack Flaherty# | 9.11 | 2015-2025 | |
| 79 | Wilmer Font | 9.10 | 2010-2020 | |
| 80 | Sean Marshall | 9.09 | 2007-2016 | |
| 81 | Cole Hamels | 9.07 | 2007-2022 | |
| 81 | Chad Billingsley | 9.07 | 2007-2015 | |
| 83 | Luis Severino# | 9.02 | 2016-2025 | |
| 83 | Corbin Burnes# | 9.02 | 2020-2025 | |
| 83 | Matt Moore# | 9.02 | 2012-2025 | |
| 83 | Gio Gonzalez | 9.02 | 2010-2022 | |
| 87 | Brandon Woodruff# | 9.01 | 2015-2025 | |
| 88 | Robbie Ross Jr. | 8.99 | 2010-2017 | |
| 89 | Ubaldo Jimenez | 8.98 | 2010-2020 | |
| 90 | Oliver Drake | 8.97 | 2010-2022 | |
| 91 | Tarik Skubal# | 8.95 | 2022-2025 | |
| 92 | Joe Smith | 8.92 | 2008-2022 | |
| 93 | Julio Urias# | 8.90 | 2018-2025 | |
| 94 | Matt Garza | 8.89 | 2009-2017 | |
| 95 | David Price | 8.86 | 2009-2023 | |
| 96 | Scott Kazmir | 8.83 | 2005-2018 | |
| 97 | Tyler Lyons | 8.80 | 2012-2020 | |
| 98 | Zac Gallen# | 8.78 | 2020-2025 | |
| 98 | Ian Kennedy | 8.78 | 2010-2022 | |
| 100 | Ryan Madson | 8.77 | 2003-2019 |
