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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K9 | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Edwin Jackson | 13.34 | 2004 | |
| 2 | Yu Darvish# | 13.21 | 2015 | |
| 3 | J.J. Franco | 12.66 | 2004 | |
| 4 | Yu Darvish# | 12.63 | 2014 | |
| 4 | Lucas Giolito# | 12.63 | 2020 | |
| 6 | Spencer Strider# | 12.59 | 2024 | |
| 7 | Smith Smith | 12.38 | 2015 | |
| 8 | Jacob Degrom# | 12.23 | 2024 | |
| 9 | Yu Darvish# | 12.06 | 2013 | |
| 10 | Felix Hernandez | 12.05 | 2014 | |
| 11 | Justin Verlander# | 11.79 | 2020 | |
| 12 | Stephen Strasburg# | 11.59 | 2013 | |
| 13 | Max Scherzer# | 11.56 | 2020 | |
| 13 | Matt Moore# | 11.56 | 2014 | |
| 15 | Oliver Perez | 11.50 | 2005 | |
| 16 | Rich Harden | 11.48 | 2010 | |
| 17 | Tyler Glasnow# | 11.45 | 2022 | |
| 18 | Jon Lester | 11.44 | 2015 | |
| 19 | Neftali Feliz | 11.43 | 2013 | |
| 20 | Stephen Strasburg# | 11.42 | 2016 | |
| 21 | Rich Hill# | 11.40 | 2018 | |
| 22 | Tim Lincecum | 11.39 | 2011 | |
| 23 | Gerrit Cole# | 11.35 | 2020 | |
| 23 | Mike Clevinger# | 11.35 | 2020 | |
| 25 | Marco Estrada | 11.30 | 2014 | |
| 26 | Smith Smith | 11.28 | 2014 | |
| 27 | Luis Severino# | 11.25 | 2020 | |
| 28 | Tim Lincecum | 11.20 | 2010 | |
| 29 | Stephen Strasburg# | 11.15 | 2014 | |
| 30 | Matt Harvey | 11.13 | 2015 | |
| 31 | Marco Estrada | 11.12 | 2015 | |
| 32 | Clayton Kershaw# | 11.11 | 2015 | |
| 33 | Tim Lincecum | 11.04 | 2012 | |
| 34 | Brandon Morrow | 11.02 | 2013 | |
| 34 | Smith Smith | 11.02 | 2014 | |
| 36 | David Price | 11.01 | 2015 | |
| 37 | David Price | 10.97 | 2014 | |
| 38 | Mitch Keller# | 10.96 | 2020 | |
| 39 | Gerrit Cole# | 10.95 | 2021 | |
| 39 | Bartolo Colon | 10.95 | 2001 | |
| 41 | Blake Snell# | 10.87 | 2022 | |
| 42 | Justin Verlander# | 10.85 | 2015 | |
| 42 | Freddy Peralta# | 10.85 | 2022 | |
| 44 | Danny Salazar | 10.84 | 2018 | |
| 45 | Shane Bieber# | 10.81 | 2022 | |
| 46 | James Paxton# | 10.80 | 2019 | |
| 47 | Anibal Sanchez | 10.79 | 2015 | |
| 47 | Chris Archer | 10.79 | 2015 | |
| 49 | Felix Hernandez | 10.78 | 2015 | |
| 49 | Mat Latos | 10.78 | 2015 | |
| 51 | Jake Peavy | 10.77 | 2015 | |
| 52 | Chris Sale# | 10.76 | 2014 | |
| 53 | Felix Hernandez | 10.72 | 2016 | |
| 54 | Cole Hamels | 10.68 | 2014 | |
| 54 | Max Scherzer# | 10.68 | 2014 | |
| 56 | Chad Billingsley | 10.66 | 2013 | |
| 57 | Chris Sale# | 10.65 | 2016 | |
| 58 | Max Scherzer# | 10.63 | 2015 | |
| 58 | Ian Kennedy | 10.63 | 2014 | |
| 60 | Shohei Ohtani# | 10.62 | 2019 | |
| 61 | Robbie Ross Jr. | 10.57 | 2010 | |
| 62 | Jeff Samardzija | 10.56 | 2014 | |
| 62 | Clayton Kershaw# | 10.56 | 2011 | |
| 64 | Sandy Koufax | 10.55 | 1962 | |
| 65 | Clayton Kershaw# | 10.54 | 2010 | |
| 65 | Walker Buehler# | 10.54 | 2019 | |
| 65 | Matt Garza | 10.54 | 2014 | |
| 68 | Jeff Samardzija | 10.52 | 2015 | |
| 69 | Clayton Kershaw# | 10.51 | 2013 | |
| 69 | Max Scherzer# | 10.51 | 2019 | |
| 71 | Jarrod Parker | 10.50 | 2013 | |
| 72 | Zack Wheeler# | 10.48 | 2015 | |
| 73 | John Danks | 10.46 | 2011 | |
| 73 | Matt Moore# | 10.46 | 2015 | |
| 73 | Jacob Degrom# | 10.46 | 2022 | |
| 73 | Tyler Mahle# | 10.46 | 2020 | |
| 77 | Matt Moore# | 10.45 | 2012 | |
| 77 | Edinson Volquez | 10.45 | 2011 | |
| 79 | Anibal Sanchez | 10.41 | 2014 | |
| 80 | Clayton Kershaw# | 10.40 | 2014 | |
| 80 | Smith Smith | 10.40 | 2013 | |
| 82 | Smith Smith | 10.37 | 2008 | |
| 82 | Julio Urias# | 10.37 | 2020 | |
| 82 | Jon Lester | 10.37 | 2014 | |
| 85 | Wilmer Font | 10.36 | 2019 | |
| 86 | Tim Lincecum | 10.35 | 2013 | |
| 87 | Stephen Strasburg# | 10.34 | 2012 | |
| 88 | Cole Hamels | 10.33 | 2013 | |
| 89 | CC Sabathia | 10.31 | 2013 | |
| 90 | Max Scherzer# | 10.30 | 2018 | |
| 91 | Chris Tillman | 10.27 | 2015 | |
| 92 | Lance McCullers Jr.# | 10.26 | 2020 | |
| 93 | Ubaldo Jimenez | 10.25 | 2014 | |
| 94 | Sandy Koufax | 10.24 | 1965 | |
| 95 | Derek Holland | 10.21 | 2014 | |
| 96 | Luis Castillo# | 10.20 | 2020 | |
| 97 | Chris Tillman | 10.18 | 2014 | |
| 97 | Clayton Kershaw# | 10.18 | 2018 | |
| 99 | Max Scherzer# | 10.17 | 2022 | |
| 100 | Edinson Volquez | 10.16 | 2013 |
