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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | OAVG | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Aroldis Chapman# | .1954 | 2011-2025 | |
| 2 | Craig Kimbrel# | .1972 | 2011-2025 | |
| 3 | Sandy Koufax | .2010 | 1955-1966 | |
| 4 | Edwin Diaz# | .2014 | 2017-2025 | |
| 5 | Kenley Jansen# | .2078 | 2012-2025 | |
| 6 | Joe Nathan | .2148 | 2000-2016 | |
| 7 | David Robertson# | .2156 | 2010-2025 | |
| 8 | Freddy Peralta# | .2157 | 2019-2025 | |
| 9 | Shane McClanahan# | .2166 | 2023-2025 | |
| 10 | Steve Hamilton | .2185 | 1961-1972 | |
| 11 | Sean Doolittle | .2190 | 2011-2022 | |
| 12 | Catfish Hunter | .2191 | 1965-1976 | |
| 13 | Jonathan Broxton | .2213 | 2007-2017 | |
| 14 | Lance McCullers Jr.# | .2215 | 2016-2025 | |
| 15 | Max Scherzer# | .2221 | 2009-2025 | |
| 16 | Smith Smith | .2236 | 2002-2018 | |
| 17 | Ryan Pressly# | .2257 | 2016-2025 | |
| 18 | Andrew Miller | .2262 | 2007-2020 | |
| 19 | Dylan Cease# | .2268 | 2015-2025 | |
| 20 | Julio Urias# | .2273 | 2018-2025 | |
| 21 | Yu Darvish# | .2277 | 2012-2025 | |
| 21 | Shawn Kelley | .2277 | 2010-2020 | |
| 21 | Darren O'Day | .2277 | 2010-2022 | |
| 24 | Adam Ottavino# | .2284 | 2010-2024 | |
| 25 | Trevor Bauer | .2287 | 2012-2023 | |
| 25 | Shohei Ohtani# | .2287 | 2018-2025 | |
| 27 | Francisco Rodriguez | .2291 | 2003-2018 | |
| 28 | Oliver Perez | .2296 | 2003-2022 | |
| 29 | Corbin Burnes# | .2297 | 2020-2025 | |
| 29 | Lucas Giolito# | .2297 | 2016-2025 | |
| 31 | Bill Stafford | .2307 | 1960-1967 | |
| 32 | Trevor Rosenthal | .2308 | 2010-2023 | |
| 32 | Huston Street | .2308 | 2005-2016 | |
| 34 | Jason Grilli | .2313 | 2001-2017 | |
| 35 | Bryse Wilson# | .2318 | 2020-2025 | |
| 35 | Tyler Clippard | .2318 | 2007-2019 | |
| 37 | Stephen Strasburg# | .2319 | 2010-2025 | |
| 38 | Caleb Ferguson# | .2322 | 2015-2025 | |
| 39 | Rafael Soriano | .2324 | 2003-2015 | |
| 40 | Shane Bieber# | .2325 | 2020-2025 | |
| 41 | Brandon Woodruff# | .2326 | 2015-2025 | |
| 42 | Larry Dierker | .2329 | 1964-1976 | |
| 43 | Raisel Iglesias# | .2331 | 2016-2025 | |
| 44 | Danny Salazar | .2339 | 2010-2021 | |
| 45 | J.P. Howell | .2341 | 2008-2017 | |
| 46 | Jeurys Familia | .2342 | 2010-2022 | |
| 46 | Brad Peacock | .2342 | 2010-2021 | |
| 46 | Jonathan Papelbon | .2342 | 2006-2017 | |
| 49 | Tarik Skubal# | .2344 | 2022-2025 | |
| 50 | Blake Snell# | .2350 | 2012-2025 | |
| 51 | Brandon Maurer | .2355 | 2010-2018 | |
| 52 | Jacob Degrom# | .2356 | 2012-2025 | |
| 52 | Robbie Ray# | .2356 | 2017-2025 | |
| 52 | Triston McKenzie# | .2356 | 2021-2025 | |
| 55 | Luke Gregerson | .2360 | 2010-2019 | |
| 55 | Clayton Kershaw# | .2360 | 2009-2025 | |
| 57 | Bob Feller | .2362 | 1947-1956 | |
| 58 | Walker Buehler# | .2368 | 2019-2025 | |
| 59 | Billy O'Dell | .2374 | 1954-1967 | |
| 60 | Jake McGee | .2377 | 2010-2022 | |
| 61 | Steve Cishek | .2378 | 2012-2021 | |
| 62 | Casey Janssen | .2379 | 2007-2016 | |
| 63 | Tanner Houck# | .2380 | 2021-2025 | |
| 64 | Luis Castillo# | .2383 | 2020-2025 | |
| 64 | Johnny Antonelli | .2383 | 1948-1961 | |
| 66 | Jose De Leon# | .2384 | 2017-2022 | |
| 67 | Evan Scribner | .2386 | 2011-2018 | |
| 68 | Wilmer Font | .2388 | 2010-2020 | |
| 68 | Pedro Strop | .2388 | 2011-2021 | |
| 68 | Matt Harvey | .2388 | 2014-2021 | |
| 71 | Carlos Rodon# | .2389 | 2015-2025 | |
| 72 | Chris Sale# | .2392 | 2011-2025 | |
| 73 | Sergio Romo | .2393 | 2010-2021 | |
| 73 | Oliver Drake | .2393 | 2010-2022 | |
| 75 | Pablo Lopez# | .2397 | 2021-2025 | |
| 75 | Hector Rondon | .2397 | 2010-2021 | |
| 77 | Tyler Glasnow# | .2399 | 2017-2025 | |
| 78 | Sean Newcomb# | .2405 | 2015-2024 | |
| 79 | Zac Gallen# | .2406 | 2020-2025 | |
| 80 | Jesse Crain | .2409 | 2006-2015 | |
| 80 | Justin Steele# | .2409 | 2015-2025 | |
| 82 | Joel Peralta | .2410 | 2005-2016 | |
| 83 | Aaron Nola# | .2413 | 2015-2025 | |
| 84 | Jose Alvarez | .2417 | 2010-2023 | |
| 84 | David Price | .2417 | 2009-2023 | |
| 84 | Felix Hernandez | .2417 | 2005-2021 | |
| 87 | Michael Lorenzen# | .2418 | 2018-2025 | |
| 88 | Justin Verlander# | .2420 | 2007-2025 | |
| 89 | Mark Melancon | .2421 | 2010-2023 | |
| 90 | Eduardo Rodriguez# | .2423 | 2012-2025 | |
| 91 | Gerrit Cole# | .2427 | 2012-2025 | |
| 92 | Wade Davis | .2429 | 2009-2020 | |
| 93 | Chris Archer | .2440 | 2012-2023 | |
| 94 | Michael Fulmer# | .2442 | 2012-2025 | |
| 95 | Smith Smith | .2443 | 2005-2014 | |
| 95 | Jake Peavy | .2443 | 2002-2018 | |
| 97 | Jesse Chavez# | .2450 | 2010-2025 | |
| 98 | Mat Latos | .2453 | 2010-2016 | |
| 99 | Liam Hendriks# | .2455 | 2012-2025 | |
| 99 | Chaz Roe | .2455 | 2010-2021 |
