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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | OAVG | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Craig Kimbrel# | .1960 | 2011-2025 | |
| 2 | Aroldis Chapman# | .1964 | 2011-2025 | |
| 3 | Sandy Koufax | .2010 | 1955-1966 | |
| 4 | Kenley Jansen# | .2075 | 2012-2025 | |
| 5 | Joe Nathan | .2148 | 2000-2016 | |
| 6 | Freddy Peralta# | .2156 | 2019-2025 | |
| 7 | David Robertson# | .2161 | 2010-2025 | |
| 8 | Shane McClanahan# | .2169 | 2023-2025 | |
| 9 | Steve Hamilton | .2185 | 1961-1972 | |
| 10 | Sean Doolittle | .2190 | 2011-2022 | |
| 11 | Catfish Hunter | .2191 | 1965-1976 | |
| 12 | Lance McCullers Jr.# | .2204 | 2016-2025 | |
| 13 | Jonathan Broxton | .2213 | 2007-2017 | |
| 14 | Max Scherzer# | .2218 | 2009-2025 | |
| 15 | Smith Smith | .2236 | 2002-2018 | |
| 16 | Andrew Miller | .2262 | 2007-2020 | |
| 17 | Dylan Cease# | .2272 | 2015-2025 | |
| 17 | Yu Darvish# | .2272 | 2012-2025 | |
| 19 | Shawn Kelley | .2277 | 2010-2020 | |
| 19 | Darren O'Day | .2277 | 2010-2022 | |
| 21 | Lucas Giolito# | .2279 | 2016-2025 | |
| 22 | Adam Ottavino# | .2284 | 2010-2024 | |
| 23 | Trevor Bauer | .2287 | 2012-2023 | |
| 23 | Shohei Ohtani# | .2287 | 2018-2025 | |
| 25 | Francisco Rodriguez | .2291 | 2003-2018 | |
| 26 | Oliver Perez | .2296 | 2003-2022 | |
| 27 | Julio Urias# | .2300 | 2018-2023 | |
| 28 | Stephen Strasburg# | .2303 | 2010-2025 | |
| 29 | Corbin Burnes# | .2304 | 2020-2025 | |
| 30 | Bryse Wilson# | .2307 | 2020-2025 | |
| 30 | Bill Stafford | .2307 | 1960-1967 | |
| 32 | Trevor Rosenthal | .2308 | 2010-2023 | |
| 32 | Huston Street | .2308 | 2005-2016 | |
| 34 | Shane Bieber# | .2312 | 2020-2025 | |
| 35 | Jason Grilli | .2313 | 2001-2017 | |
| 36 | Tyler Clippard | .2318 | 2007-2019 | |
| 37 | Raisel Iglesias# | .2321 | 2016-2025 | |
| 38 | Rafael Soriano | .2324 | 2003-2015 | |
| 39 | Brandon Woodruff# | .2325 | 2015-2025 | |
| 40 | Caleb Ferguson# | .2327 | 2015-2025 | |
| 41 | Larry Dierker | .2329 | 1964-1976 | |
| 42 | Walker Buehler# | .2334 | 2019-2025 | |
| 43 | Danny Salazar | .2339 | 2010-2021 | |
| 44 | J.P. Howell | .2341 | 2008-2017 | |
| 45 | Jeurys Familia | .2342 | 2010-2022 | |
| 45 | Brad Peacock | .2342 | 2010-2021 | |
| 45 | Jonathan Papelbon | .2342 | 2006-2017 | |
| 48 | Blake Snell# | .2350 | 2012-2025 | |
| 49 | Clayton Kershaw# | .2353 | 2009-2025 | |
| 50 | Brandon Maurer | .2355 | 2010-2018 | |
| 51 | Robbie Ray# | .2356 | 2017-2025 | |
| 52 | Luke Gregerson | .2360 | 2010-2019 | |
| 52 | Jacob Degrom# | .2360 | 2012-2025 | |
| 54 | Bob Feller | .2362 | 1947-1956 | |
| 55 | Triston McKenzie# | .2363 | 2021-2025 | |
| 56 | Billy O'Dell | .2374 | 1954-1967 | |
| 57 | Jake McGee | .2377 | 2010-2022 | |
| 58 | Steve Cishek | .2378 | 2012-2021 | |
| 59 | Casey Janssen | .2379 | 2007-2016 | |
| 60 | Johnny Antonelli | .2383 | 1948-1961 | |
| 61 | Jose De Leon# | .2384 | 2017-2022 | |
| 62 | Evan Scribner | .2386 | 2011-2018 | |
| 62 | Luis Castillo# | .2386 | 2020-2025 | |
| 64 | Wilmer Font | .2388 | 2010-2020 | |
| 64 | Pedro Strop | .2388 | 2011-2021 | |
| 64 | Matt Harvey | .2388 | 2014-2021 | |
| 67 | Tarik Skubal# | .2391 | 2022-2025 | |
| 68 | Pablo Lopez# | .2392 | 2021-2025 | |
| 69 | Sergio Romo | .2393 | 2010-2021 | |
| 69 | Oliver Drake | .2393 | 2010-2022 | |
| 71 | Chris Sale# | .2395 | 2011-2025 | |
| 72 | Hector Rondon | .2397 | 2010-2021 | |
| 72 | Justin Steele# | .2397 | 2015-2025 | |
| 74 | Tyler Glasnow# | .2402 | 2017-2025 | |
| 75 | Sean Newcomb# | .2405 | 2015-2024 | |
| 76 | Jesse Crain | .2409 | 2006-2015 | |
| 77 | Joel Peralta | .2410 | 2005-2016 | |
| 77 | Aaron Nola# | .2410 | 2015-2025 | |
| 79 | Carlos Rodon# | .2411 | 2015-2025 | |
| 80 | Jose Alvarez | .2417 | 2010-2023 | |
| 80 | David Price | .2417 | 2009-2023 | |
| 80 | Felix Hernandez | .2417 | 2005-2021 | |
| 80 | Michael Lorenzen# | .2417 | 2018-2025 | |
| 84 | Justin Verlander# | .2420 | 2007-2025 | |
| 85 | Mark Melancon | .2421 | 2010-2023 | |
| 86 | Gerrit Cole# | .2422 | 2012-2025 | |
| 87 | Eduardo Rodriguez# | .2423 | 2012-2025 | |
| 88 | Tanner Houck# | .2426 | 2021-2025 | |
| 89 | Wade Davis | .2429 | 2009-2020 | |
| 90 | Zac Gallen# | .2436 | 2020-2025 | |
| 91 | Chris Archer | .2440 | 2012-2023 | |
| 92 | Smith Smith | .2443 | 2005-2014 | |
| 92 | Jake Peavy | .2443 | 2002-2018 | |
| 92 | Liam Hendriks# | .2443 | 2012-2025 | |
| 95 | Jeff Hoffman# | .2449 | 2015-2025 | |
| 96 | Mat Latos | .2453 | 2010-2016 | |
| 97 | Michael Fulmer# | .2455 | 2012-2025 | |
| 97 | Chaz Roe | .2455 | 2010-2021 | |
| 97 | Joakim Soria | .2455 | 2007-2020 | |
| 100 | Tanner Scheppers | .2457 | 2010-2016 |
