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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | OAVG | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Shane Bieber# | .1747 | 2022 | |
| 2 | Sandy Koufax | .1766 | 1965 | |
| 3 | Yu Darvish# | .1768 | 2015 | |
| 4 | Lucas Giolito# | .1787 | 2020 | |
| 5 | Walker Buehler# | .1821 | 2019 | |
| 6 | Catfish Hunter | .1842 | 1972 | |
| 7 | Anthony Bass | .1846 | 2011 | |
| 8 | Freddy Peralta# | .1862 | 2024 | |
| 9 | Sandy Koufax | .1866 | 1963 | |
| 10 | Bartolo Colon | .1871 | 2001 | |
| 10 | Sandy Koufax | .1871 | 1964 | |
| 12 | Max Scherzer# | .1893 | 2020 | |
| 13 | Yu Darvish# | .1907 | 2014 | |
| 14 | Sandy Koufax | .1951 | 1962 | |
| 15 | John Lackey | .1970 | 2008 | |
| 16 | Shane McClanahan# | .1974 | 2024 | |
| 17 | Robbie Ray# | .1975 | 2019 | |
| 18 | Freddy Peralta# | .1991 | 2021 | |
| 19 | Sandy Koufax | .1992 | 1966 | |
| 20 | Catfish Hunter | .2013 | 1975 | |
| 21 | Sandy Koufax | .2021 | 1960 | |
| 22 | Tim Melville | .2030 | 2011 | |
| 22 | Oliver Perez | .2030 | 2005 | |
| 24 | Felix Hernandez | .2031 | 2012 | |
| 24 | Shelby Miller# | .2031 | 2018 | |
| 26 | Shohei Ohtani# | .2032 | 2020 | |
| 27 | Robbie Ross Jr. | .2034 | 2010 | |
| 28 | Justin Verlander# | .2038 | 2020 | |
| 29 | Smith Smith | .2039 | 2013 | |
| 29 | Yu Darvish# | .2039 | 2016 | |
| 31 | Bob Feller | .2041 | 1947 | |
| 32 | David Price | .2047 | 2015 | |
| 33 | Mike Foltynewicz | .2052 | 2019 | |
| 34 | Greg Smith | .2055 | 2010 | |
| 35 | Yu Darvish# | .2066 | 2013 | |
| 36 | Jacob Degrom# | .2073 | 2024 | |
| 37 | Freddy Peralta# | .2074 | 2022 | |
| 38 | Larry Dierker | .2076 | 1969 | |
| 39 | Blake Snell# | .2077 | 2022 | |
| 40 | Lucas Giolito# | .2078 | 2021 | |
| 41 | Wade Miley# | .2080 | 2010 | |
| 42 | Aaron Poreda | .2081 | 2010 | |
| 43 | Max Scherzer# | .2083 | 2022 | |
| 44 | Yovani Gallardo | .2085 | 2012 | |
| 44 | Masahiro Tanaka | .2085 | 2019 | |
| 44 | Matt Harvey | .2085 | 2015 | |
| 47 | Jacob Degrom# | .2088 | 2022 | |
| 48 | Chris Tillman | .2093 | 2015 | |
| 49 | Felix Hernandez | .2095 | 2013 | |
| 49 | Danny Salazar | .2095 | 2017 | |
| 51 | Zack Wheeler# | .2101 | 2015 | |
| 52 | Spencer Strider# | .2102 | 2024 | |
| 52 | Max Scherzer# | .2102 | 2018 | |
| 54 | Max Scherzer# | .2107 | 2019 | |
| 54 | Lance McCullers Jr.# | .2107 | 2020 | |
| 56 | Felix Hernandez | .2109 | 2011 | |
| 57 | Madison Bumgarner | .2110 | 2018 | |
| 58 | Stephen Strasburg# | .2111 | 2014 | |
| 59 | Jordan Montgomery# | .2112 | 2022 | |
| 60 | Michael Wacha# | .2114 | 2024 | |
| 61 | Catfish Hunter | .2115 | 1967 | |
| 62 | Clayton Kershaw# | .2119 | 2015 | |
| 63 | Shane Bieber# | .2122 | 2020 | |
| 63 | Johnny Antonelli | .2122 | 1954 | |
| 65 | Max Scherzer# | .2127 | 2015 | |
| 66 | Chris Archer | .2135 | 2016 | |
| 66 | Jose Quintana# | .2135 | 2018 | |
| 68 | Shane McClanahan# | .2136 | 2023 | |
| 69 | Clayton Kershaw# | .2140 | 2018 | |
| 69 | Max Scherzer# | .2140 | 2017 | |
| 71 | Billy O'Dell | .2142 | 1959 | |
| 72 | Clayton Kershaw# | .2145 | 2013 | |
| 72 | Wilmer Font | .2145 | 2018 | |
| 74 | Aaron Harang | .2146 | 2008 | |
| 75 | Josh M. Johnson | .2149 | 2006 | |
| 76 | Scott Kazmir | .2151 | 2008 | |
| 76 | Catfish Hunter | .2151 | 1971 | |
| 78 | Corbin Burnes# | .2152 | 2022 | |
| 79 | J.P. Howell | .2153 | 2008 | |
| 80 | Gerrit Cole# | .2158 | 2020 | |
| 80 | Andrew Heaney# | .2158 | 2020 | |
| 82 | Lance McCullers Jr.# | .2164 | 2022 | |
| 83 | Jacob Degrom# | .2165 | 2019 | |
| 83 | Sandy Koufax | .2165 | 1961 | |
| 85 | Clayton Kershaw# | .2169 | 2012 | |
| 86 | Lance Lynn# | .2170 | 2020 | |
| 87 | Gerrit Cole# | .2172 | 2023 | |
| 88 | Oliver Perez | .2173 | 2009 | |
| 89 | Matt Cain | .2174 | 2015 | |
| 90 | Shohei Ohtani# | .2176 | 2019 | |
| 91 | Justin Steele# | .2180 | 2024 | |
| 92 | Brandon Woodruff# | .2181 | 2018 | |
| 93 | Kyle McPherson | .2183 | 2011 | |
| 93 | Mike Clevinger# | .2183 | 2021 | |
| 95 | Blake Snell# | .2184 | 2024 | |
| 95 | Felix Hernandez | .2184 | 2015 | |
| 95 | Eduardo Rodriguez# | .2184 | 2020 | |
| 98 | Sean Newcomb# | .2185 | 2021 | |
| 99 | Lance McCullers Jr.# | .2188 | 2021 | |
| 99 | Dylan Cease# | .2188 | 2024 |
