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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K9 | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Dellin Betances | 16.65 | 2011-2021 | |
| 2 | Craig Kimbrel# | 13.25 | 2011-2025 | |
| 3 | Stephen Strasburg# | 13.22 | 2010-2025 | |
| 4 | Blake Snell# | 12.64 | 2012-2025 | |
| 5 | Matt Moore# | 11.37 | 2012-2025 | |
| 6 | Corbin Burnes# | 11.06 | 2020-2025 | |
| 7 | Mat Latos | 10.91 | 2010-2016 | |
| 8 | Trevor Bauer | 10.86 | 2012-2023 | |
| 8 | Jon Niese | 10.86 | 2009-2016 | |
| 10 | Smith Smith | 10.60 | 2004-2017 | |
| 10 | Shohei Ohtani# | 10.60 | 2018-2025 | |
| 12 | Nathan Eovaldi# | 10.37 | 2012-2025 | |
| 13 | Gio Gonzalez | 10.19 | 2010-2022 | |
| 14 | Charlie Morton# | 10.06 | 2010-2025 | |
| 15 | Zack Wheeler# | 9.89 | 2010-2025 | |
| 16 | David Price | 9.64 | 2009-2023 | |
| 17 | Sandy Koufax | 9.63 | 1955-1966 | |
| 18 | Walker Buehler# | 9.61 | 2019-2025 | |
| 19 | Justin Verlander# | 9.60 | 2007-2025 | |
| 20 | Merrill Kelly# | 9.55 | 2019-2025 | |
| 21 | Freddy Peralta# | 9.45 | 2019-2025 | |
| 22 | Tarik Skubal# | 9.26 | 2022-2025 | |
| 23 | Madison Bumgarner | 9.21 | 2011-2023 | |
| 24 | Aaron Nola# | 9.17 | 2015-2025 | |
| 25 | Wade Davis | 9.06 | 2009-2020 | |
| 26 | Jacob Degrom# | 9.04 | 2012-2025 | |
| 27 | Yu Darvish# | 8.94 | 2012-2025 | |
| 28 | Julio Urias# | 8.90 | 2018-2025 | |
| 29 | Clayton Kershaw# | 8.85 | 2009-2025 | |
| 30 | Derek Holland | 8.83 | 2010-2019 | |
| 31 | Gerrit Cole# | 8.74 | 2012-2025 | |
| 32 | Edinson Volquez | 8.64 | 2008-2020 | |
| 33 | Jaime Garcia | 8.63 | 2011-2017 | |
| 34 | Michael Pineda | 8.54 | 2011-2023 | |
| 35 | Jeurys Familia | 8.46 | 2010-2022 | |
| 35 | Carlos Rodon# | 8.46 | 2015-2025 | |
| 37 | Pablo Lopez# | 8.31 | 2021-2025 | |
| 38 | Chris Archer | 8.12 | 2012-2023 | |
| 39 | Max Scherzer# | 8.11 | 2009-2025 | |
| 40 | Dylan Cease# | 8.04 | 2015-2025 | |
| 41 | Corey Kluber | 8.00 | 2011-2023 | |
| 42 | Shane McClanahan# | 7.94 | 2023-2025 | |
| 43 | Marcus Stroman# | 7.71 | 2015-2025 | |
| 44 | Homer Bailey | 7.56 | 2009-2020 | |
| 45 | Johnny Cueto | 7.53 | 2010-2023 | |
| 46 | Hyun-Jin Ryu | 7.50 | 2013-2023 | |
| 47 | Lance McCullers Jr.# | 7.43 | 2016-2025 | |
| 48 | Adam Wainwright | 7.38 | 2004-2023 | |
| 49 | Carlos Carrasco | 7.32 | 2010-2023 | |
| 50 | Chris Jones | 7.20 | 2010-2012 | |
| 51 | Ryan Pressley | 7.16 | 2010-2012 | |
| 52 | Tyler Mahle# | 6.91 | 2017-2025 | |
| 53 | Cole Hamels | 6.82 | 2007-2022 | |
| 54 | Chad Bettis | 6.69 | 2012-2019 | |
| 55 | German Marquez# | 6.56 | 2018-2025 | |
| 56 | Jake Odorizzi | 6.55 | 2012-2023 | |
| 57 | Jose Quintana# | 6.54 | 2013-2025 | |
| 58 | Matthew Boyd# | 6.46 | 2019-2025 | |
| 59 | Kyle Hendricks# | 6.27 | 2016-2024 | |
| 60 | Logan Webb# | 5.93 | 2015-2025 | |
| 61 | Miles Mikolas# | 5.57 | 2010-2025 | |
| 62 | Justin Souza | 5.34 | 2012-2012 | |
| 63 | Catfish Hunter | 4.87 | 1965-1976 | |
| 64 | Ross Detwiler | 4.75 | 2011-2023 |
