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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | H | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Billy O'Dell | 282 | 1962 | |
| 2 | Paul Maholm | 271 | 2012 | |
| 3 | Catfish Hunter | 268 | 1976 | |
| 3 | Joe Blanton | 268 | 2010 | |
| 3 | Catfish Hunter | 268 | 1974 | |
| 6 | Mike Leake | 265 | 2017 | |
| 7 | Larry Dierker | 263 | 1970 | |
| 7 | John Danks | 263 | 2018 | |
| 9 | Wily Peralta | 260 | 2017 | |
| 10 | Brett Anderson | 258 | 2017 | |
| 11 | Collin McHugh | 257 | 2017 | |
| 12 | Adam Wainwright | 256 | 2016 | |
| 13 | Bob Feller | 255 | 1948 | |
| 14 | James Happ | 253 | 2017 | |
| 14 | Catfish Hunter | 253 | 1970 | |
| 14 | Mike Leake | 253 | 2014 | |
| 17 | Paul Maholm | 251 | 2013 | |
| 18 | Doug Fister | 250 | 2012 | |
| 19 | Catfish Hunter | 248 | 1975 | |
| 19 | James Shields | 248 | 2017 | |
| 19 | Phil Hughes | 248 | 2015 | |
| 19 | Henderson Alvarez | 248 | 2015 | |
| 19 | James Shields | 248 | 2009 | |
| 24 | Carlos Carrasco | 247 | 2014 | |
| 24 | Johnny Antonelli | 247 | 1959 | |
| 24 | Hisashi Iwakuma | 247 | 2017 | |
| 27 | Austin Voth# | 246 | 2019 | |
| 27 | CC Sabathia | 246 | 2017 | |
| 27 | Aaron Harang | 246 | 2004 | |
| 30 | Brett Anderson | 245 | 2011 | |
| 31 | Jimmy Nelson | 244 | 2017 | |
| 31 | Hisashi Iwakuma | 244 | 2018 | |
| 31 | Marco Estrada | 244 | 2017 | |
| 31 | Smith Smith | 244 | 2007 | |
| 35 | Clay Buchholz | 242 | 2016 | |
| 35 | Clay Buchholz | 242 | 2014 | |
| 35 | Mike Minor | 242 | 2016 | |
| 35 | Jordan Zimmermann | 242 | 2014 | |
| 39 | Sandy Koufax | 241 | 1966 | |
| 39 | Scott Kazmir | 241 | 2010 | |
| 39 | Mike Leake | 241 | 2019 | |
| 42 | Larry Dierker | 240 | 1969 | |
| 43 | Bob Feller | 239 | 1951 | |
| 43 | Jarred Cosart | 239 | 2017 | |
| 45 | Luis Mendoza | 238 | 2012 | |
| 45 | Vance Worley | 238 | 2015 | |
| 45 | Kyle Kendrick | 238 | 2013 | |
| 45 | Doug Fister | 238 | 2014 | |
| 49 | Smith Smith | 237 | 2011 | |
| 49 | Brandon McCarthy | 237 | 2015 | |
| 51 | Chris Tillman | 236 | 2017 | |
| 51 | Brian Duensing | 236 | 2010 | |
| 53 | Smith Smith | 235 | 2011 | |
| 53 | Jered Weaver | 235 | 2011 | |
| 53 | Brandon McCarthy | 235 | 2017 | |
| 53 | Brett Anderson | 235 | 2016 | |
| 53 | Bartolo Colon | 235 | 2003 | |
| 58 | Russ Kemmerer | 234 | 1958 | |
| 58 | Smith Smith | 234 | 2009 | |
| 58 | Joe Blanton | 234 | 2008 | |
| 58 | Brett Anderson | 234 | 2013 | |
| 62 | Smith Smith | 233 | 2012 | |
| 62 | Sandy Alcantara# | 233 | 2022 | |
| 62 | Smith Smith | 233 | 2005 | |
| 62 | Jordan Zimmermann | 233 | 2017 | |
| 62 | Jameson Taillon# | 233 | 2017 | |
| 67 | James Paxton# | 232 | 2017 | |
| 67 | Smith Smith | 232 | 2004 | |
| 67 | Jacob Degrom# | 232 | 2017 | |
| 70 | Wily Peralta | 231 | 2016 | |
| 70 | Jon Niese | 231 | 2015 | |
| 72 | Jaime Garcia | 230 | 2014 | |
| 72 | Rick Porcello | 230 | 2016 | |
| 72 | Bob Feller | 230 | 1947 | |
| 72 | Tim Lincecum | 230 | 2011 | |
| 72 | Matt Harrison | 230 | 2015 | |
| 72 | Bob Feller | 230 | 1950 | |
| 78 | James Shields | 229 | 2015 | |
| 78 | Kyle Freeland# | 229 | 2023 | |
| 78 | Jason Marquis | 229 | 2005 | |
| 78 | Matt Cain | 229 | 2016 | |
| 78 | Madison Bumgarner | 229 | 2017 | |
| 78 | Ryan Madson | 229 | 2005 | |
| 78 | CC Sabathia | 229 | 2010 | |
| 78 | Miles Mikolas# | 229 | 2024 | |
| 78 | Yovani Gallardo | 229 | 2016 | |
| 78 | Anthony DeSclafani# | 229 | 2018 | |
| 78 | Tsuyoshi Wada | 229 | 2016 | |
| 78 | John Lackey | 229 | 2015 | |
| 78 | Ricky Nolasco | 229 | 2017 | |
| 91 | Johnny Antonelli | 228 | 1957 | |
| 91 | Jaime Garcia | 228 | 2016 | |
| 91 | Mike Leake | 228 | 2013 | |
| 91 | Jason Vargas | 228 | 2014 | |
| 91 | Smith Smith | 228 | 2010 | |
| 96 | Mike Montgomery | 227 | 2016 | |
| 96 | Jered Weaver | 227 | 2014 | |
| 96 | Jose Quintana# | 227 | 2017 | |
| 96 | James Shields | 227 | 2016 | |
| 100 | Smith Smith | 226 | 2016 |
