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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Player | From-To | W | L | Pct | ERA | G | GS | CG | SHO | SV | IP | H | ER | HR | BB | SO |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Edwin Uceta | 2025-2025 | 6 | 2 | .750 | 2.23 | 56 | 0 | 0 | 0 | 6 | 60.2 | 63 | 15 | 5 | 23 | 80 |
| Koji Uehara | 2009-2018 | 48 | 43 | .527 | 3.67 | 566 | 53 | 4 | 0 | 62 | 818.0 | 777 | 334 | 94 | 206 | 958 |
| Deion Ulmer | 2015-2015 | 3 | 7 | .300 | 6.00 | 15 | 15 | 0 | 0 | 0 | 99.0 | 103 | 66 | 14 | 77 | 74 |
| Duane Underwood Jr. | 2018-2019 | 2 | 1 | .667 | 9.59 | 15 | 0 | 0 | 0 | 0 | 25.1 | 35 | 27 | 7 | 20 | 17 |
| Dylan Unsworth | 2018-2019 | 3 | 3 | .500 | 7.87 | 21 | 5 | 0 | 0 | 0 | 50.1 | 67 | 44 | 16 | 19 | 32 |
| Justin Upton | 2007-2022 | 0 | 0 | .000 | 9.00 | 1 | 0 | 0 | 0 | 0 | 1.0 | 2 | 1 | 1 | 1 | 0 |
| Austin Urban | 2012-2012 | 4 | 3 | .571 | 1.48 | 10 | 9 | 1 | 1 | 0 | 66.2 | 57 | 11 | 0 | 5 | 39 |
| Jose Urena | 2019-2022 | 9 | 19 | .321 | 5.34 | 151 | 29 | 0 | 0 | 5 | 278.0 | 334 | 165 | 44 | 108 | 174 |
| Richard Urena | 2018-2020 | 0 | 0 | .000 | 0.00 | 1 | 0 | 0 | 0 | 0 | 1.1 | 0 | 0 | 0 | 3 | 2 |
| Julio Urias | 2018-2025 | 47 | 43 | .522 | 3.92 | 164 | 134 | 2 | 2 | 3 | 835.1 | 712 | 364 | 126 | 231 | 826 |
| Jose Urquidy | 2021-2024 | 19 | 20 | .487 | 4.72 | 63 | 63 | 0 | 0 | 0 | 348.2 | 371 | 183 | 40 | 78 | 242 |
