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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salinas, Royber | SP | London Wolverines | 24 | 04/10/2001 | Guarenas | VEN | Right | Right | 6' 3" | 205 lbs | - |
| Santos, Antonio | SP | Quebec Castors | 28 | 10/06/1996 | Villa Gonzalez | DOM | Right | Right | 6' 3" | 185 lbs | - |
| Sauer, Matt | SP | Quebec Castors | 26 | 01/21/1999 | Unknown | USA | Right | Right | 6' 4" | 200 lbs | - |
| Schulfer, Austin | RP | Champagne Black Bears | 29 | 12/22/1995 | Plover | USA | Right | Right | 6' 2" | 175 lbs | - |
| Seijas, Alvaro | RP | Plattsburgh Beacons | 26 | 10/10/1998 | Maracay | VEN | Right | Right | 6' 1" | 180 lbs | - |
| Seminaris, Adam | SP | Dayton Dragons | 26 | 10/19/1998 | Pomona | USA | Right | Left | 6' 0" | 185 lbs | - |
| Senger, Hayden | C | Canton Cutters | 28 | 04/03/1997 | Virginia Beach | USA | Right | Right | 6' 1" | 210 lbs | - |
| Severino, Anderson | RP | Harrisburg Senators | 30 | 09/17/1994 | Unknown | DOM | Left | Left | 5' 10" | 165 lbs | - |
| Shackelford, Aaron | 2B | Champagne Black Bears | 28 | 10/16/1996 | Murrieta | USA | Left | Right | 5' 10" | 205 lbs | - |
| Sharp, Jacob | C | Plattsburgh Beacons | 23 | 09/15/2001 | La Mirada | USA | Right | Right | 5' 11" | 195 lbs | - |
| Shewmake, Braden | 2B | London Wolverines | 27 | 11/19/1997 | Wylie | USA | Left | Right | 6' 4" | 190 lbs | - |
| Short, Avery | SP | Champagne Black Bears | 24 | 03/14/2001 | Indianapolis | USA | Right | Left | 6' 1" | 205 lbs | - |
| Shortridge, Aaron | SP | Plattsburgh Beacons | 27 | 05/29/1997 | Santa Rosa | USA | Right | Right | 6' 3" | 195 lbs | - |
| Siani, Sammy | CF | Dayton Dragons | 24 | 12/14/2000 | Glenside | USA | Left | Left | 6' 0" | 195 lbs | - |
| Sikes, Phillip | CF | Hempstead Flying Dutchmen | 25 | 04/27/1999 | Paris | USA | Right | Right | 6' 2" | 190 lbs | - |
| Sinclair, Jack | RP | Madison Millers | 25 | 05/03/1999 | Coral Springs | USA | Right | Right | 6' 4" | 170 lbs | - |
| Skipper, Carson | RP | Reading Roughnecks | 25 | 08/12/1999 | Unknown | USA | Left | Left | 6' 3" | 210 lbs | - |
| Smith, Chad C. | CL | Albany Ambassadors | 29 | 06/08/1995 | Bessemer | USA | Right | Right | 6' 4" | 205 lbs | - |
| Smith, Julian | RP | Madison Millers | 27 | 06/06/1997 | Concord | USA | Right | Left | 6' 4" | 190 lbs | - |
| Snider, Jake | 3B | Champagne Black Bears | 26 | 05/19/1998 | Champaign | USA | Left | Right | 6' 1" | 190 lbs | - |
| Solesky, Chase | SP | Quebec Castors | 27 | 09/26/1997 | Fort Pierce | USA | Right | Right | 6' 3" | 200 lbs | - |
| Sommers, Drew | RP | Hempstead Flying Dutchmen | 24 | 08/14/2000 | Unknown | USA | Left | Left | 6' 3" | 250 lbs | - |
| Song, Noah | SP | Canton Cutters | 27 | 05/28/1997 | Claremont | USA | Right | Right | 6' 4" | 200 lbs | - |
| Sproat, Brandon | SP | Canton Cutters | 24 | 09/17/2000 | Pace | USA | Right | Right | 6' 3" | 215 lbs | - |
| Stallings, Garrett | RP | Canton Cutters | 27 | 08/08/1997 | Chesapeake | USA | Right | Right | 6' 2" | 200 lbs | - |
| Stauffer, Adam | SP | Hempstead Flying Dutchmen | 26 | 01/13/1999 | Coatesville | USA | Right | Right | 6' 7" | 240 lbs | - |
| Stevens, Felix | LF | Reading Roughnecks | 25 | 07/30/1999 | Havana | CUB | Right | Right | 6' 4" | 235 lbs | - |
| Stone, Gavin | SP | London Wolverines | 26 | 10/15/1998 | Unknown | USA | Right | Right | 6' 1" | 175 lbs | - |
| Stoudt, Levi | SP | Trenton Thunder | 27 | 12/04/1997 | Greenville | USA | Right | Right | 6' 1" | 195 lbs | - |
| Stout, Eric | RP | Madison Millers | 32 | 03/27/1993 | Unknown | USA | Left | Left | 6' 3" | 185 lbs | - |
| Strong, Hunter | RP | Hempstead Flying Dutchmen | 28 | 03/25/1997 | Sheridan | USA | Left | Left | 6' 1" | 205 lbs | - |
| Suarez, Andrew | SP | London Wolverines | 32 | 09/11/1992 | Unknown | USA | Left | Left | 6' 2" | 210 lbs | - |
| Sundstrom, Jared | LF | Plattsburgh Beacons | 23 | 06/21/2001 | Santa Rosa | USA | Right | Right | 6' 3" | 225 lbs | - |
