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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salazar, Cesar | C | Harrisburg Senators | 29 | 03/15/1996 | South Tucson | USA | Left | Right | 5' 9" | 185 lbs | - |
| Salinas, Royber | SP | London Wolverines | 24 | 04/10/2001 | Guarenas | VEN | Right | Right | 6' 3" | 205 lbs | - |
| Sanmartin, Reiver | SP | Quebec Castors | 29 | 04/15/1996 | Cartagena | COL | Left | Left | 6' 2" | 155 lbs | - |
| Santos, Dahian | SP | Trenton Thunder | 22 | 02/26/2003 | Acarigua | VEN | Right | Right | 5' 11" | 160 lbs | - |
| Sauer, Matt | SP | Quebec Castors | 26 | 01/21/1999 | Unknown | USA | Right | Right | 6' 4" | 200 lbs | - |
| Sayre, Alec | LF | Trenton Thunder | 25 | 10/05/2000 | Princeton Junction | USA | Right | Right | 6' 0" | 195 lbs | - |
| Schobel, Tanner | 2B | Champagne Black Bears | 24 | 06/04/2001 | Unknown | USA | Right | Right | 5' 10" | 170 lbs | - |
| Scholtens, Jesse | SP | Trenton Thunder | 31 | 04/06/1994 | Fairfield | USA | Right | Right | 6' 4" | 240 lbs | - |
| Schreffler, Troy | LF | Harrisburg Senators | 24 | 10/27/2000 | Unknown | USA | Right | Right | 6' 1" | 190 lbs | - |
| Schultz, Paxton | SP | Trenton Thunder | 27 | 01/05/1998 | Orem | USA | Left | Right | 6' 3" | 205 lbs | - |
| Schultz, Thomas | RP | Harrisburg Senators | 26 | 08/03/1999 | Unknown | USA | Right | Right | 6' 6" | 215 lbs | - |
| Seise, Chris | SS | Albany Ambassadors | 26 | 01/06/1999 | Unknown | USA | Right | Right | 6' 2" | 180 lbs | - |
| Seminaris, Adam | SP | Dayton Dragons | 26 | 10/19/1998 | Pomona | USA | Right | Left | 6' 0" | 185 lbs | - |
| Senger, Hayden | C | Canton Cutters | 28 | 04/03/1997 | Virginia Beach | USA | Right | Right | 6' 1" | 210 lbs | - |
| Seymour, Carson | SP | London Wolverines | 26 | 12/16/1998 | Poway | USA | Right | Right | 6' 5" | 250 lbs | - |
| Seymour, Ian | SP | London Wolverines | 26 | 12/13/1998 | Unknown | USA | Left | Left | 6' 0" | 190 lbs | - |
| Sharpe, Chris | LF | Reading Roughnecks | 29 | 06/06/1996 | Unknown | USA | Right | Right | 6' 1" | 200 lbs | - |
| Shaver, Colton | C | Quebec Castors | 30 | 09/18/1995 | Unknown | USA | Right | Right | 6' 1" | 210 lbs | - |
| Shortridge, Aaron | SP | Plattsburgh Beacons | 28 | 05/29/1997 | Santa Rosa | USA | Right | Right | 6' 3" | 195 lbs | - |
| Siani, Sammy | CF | Dayton Dragons | 24 | 12/14/2000 | Glenside | USA | Left | Left | 6' 0" | 195 lbs | - |
| Simoneit, William | 1B | Hempstead Flying Dutchmen | 28 | 10/14/1996 | Glen Ellyn | USA | Right | Right | 6' 4" | 235 lbs | - |
| Singleton, Jon | 1B | Albany Ambassadors | 34 | 09/18/1991 | Lakewood | USA | Left | Left | 6' 2" | 225 lbs | - |
| Smeltzer, Devin | SP | Madison Millers | 30 | 09/07/1995 | Voorheesville | USA | Right | Left | 6' 3" | 190 lbs | - |
| Snider, Jake | 3B | Champagne Black Bears | 27 | 05/19/1998 | Champaign | USA | Left | Right | 6' 1" | 190 lbs | - |
| Solesky, Chase | SP | Quebec Castors | 28 | 09/26/1997 | Fort Pierce | USA | Right | Right | 6' 3" | 200 lbs | - |
| Song, Noah | RP | Canton Cutters | 28 | 05/28/1997 | Claremont | USA | Right | Right | 6' 4" | 200 lbs | - |
| Sproat, Brandon | RP | Canton Cutters | 25 | 09/17/2000 | Pace | USA | Right | Right | 6' 3" | 215 lbs | - |
| Stallings, Garrett | RP | Canton Cutters | 28 | 08/08/1997 | Chesapeake | USA | Right | Right | 6' 2" | 200 lbs | - |
| Stambaugh, Dalton | SP | Quebec Castors | 28 | 02/11/1997 | Morehead | USA | Right | Left | 6' 0" | 195 lbs | - |
| Stevens, Felix | LF | Reading Roughnecks | 26 | 07/30/1999 | Havana | CUB | Right | Right | 6' 4" | 235 lbs | - |
| Sundstrom, Jared | LF | Plattsburgh Beacons | 24 | 06/21/2001 | Santa Rosa | USA | Right | Right | 6' 3" | 225 lbs | - |
| Susac, Daniel | C | Canton Cutters | 24 | 05/14/2001 | Unknown | USA | Switch | Right | 6' 4" | 205 lbs | - |
| Swan, Eriq | SP | London Wolverines | 23 | 10/31/2001 | Murfreesboro | USA | Right | Right | 6' 6" | 240 lbs | - |
