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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salinas, Royber | SP | London Wolverines | 25 | 04/10/2001 | Guarenas | VEN | Right | Right | 6' 3" | 205 lbs | - |
| Santana, Adrian | SS | Harrisburg Senators | 20 | 07/18/2005 | Miami | USA | Switch | Right | 6' 0" | 160 lbs | - |
| Santos, Antonio | SP | Quebec Castors | 29 | 10/06/1996 | Villa Gonzalez | DOM | Right | Right | 6' 3" | 185 lbs | - |
| Scherff, Alex | RP | Harrisburg Senators | 28 | 02/05/1998 | Unknown | USA | Switch | Right | 6' 3" | 210 lbs | - |
| Schreffler, Troy | LF | Harrisburg Senators | 25 | 10/27/2000 | Unknown | USA | Right | Right | 6' 1" | 190 lbs | - |
| Schultz, Thomas | RP | Harrisburg Senators | 26 | 08/03/1999 | Unknown | USA | Right | Right | 6' 6" | 215 lbs | - |
| Scull, Anthony | CF | Plattsburgh Beacons | 22 | 01/26/2004 | Havana | CUB | Left | Left | 6' 0" | 165 lbs | - |
| Sears, Brett | RP | Plattsburgh Beacons | 26 | 05/02/2000 | Harlan | USA | Right | Right | 6' 1" | 200 lbs | - |
| Seigler, Anthony | C | Trenton Thunder | 26 | 06/20/1999 | Cartersville | USA | Switch | Right | 6' 0" | 200 lbs | - |
| Selby, Colin | RP | Dayton Dragons | 28 | 10/24/1997 | Chesapeake | USA | Right | Right | 6' 1" | 220 lbs | - |
| Serna, Jared | 2B | Dayton Dragons | 23 | 06/01/2002 | Guaymas | MEX | Right | Right | 5' 8" | 170 lbs | - |
| Seymour, Carson | SP | London Wolverines | 27 | 12/16/1998 | Poway | USA | Right | Right | 6' 5" | 250 lbs | - |
| Shackelford, Aaron | 1B | Champagne Black Bears | 29 | 10/16/1996 | Murrieta | USA | Left | Right | 5' 10" | 205 lbs | - |
| Sharp, Jacob | C | Plattsburgh Beacons | 24 | 09/15/2001 | La Mirada | USA | Right | Right | 5' 11" | 195 lbs | - |
| Sharpe, Chris | LF | Reading Roughnecks | 29 | 06/06/1996 | Unknown | USA | Right | Right | 6' 1" | 200 lbs | - |
| Shaw, Evan | RP | Trenton Thunder | 25 | 02/02/2001 | Fridley | USA | Left | Left | 6' 4" | 205 lbs | - |
| Shore, Logan | SP | Madison Millers | 31 | 12/28/1994 | Coon Rapids | USA | Right | Right | 6' 2" | 210 lbs | - |
| Short, Avery | SP | Champagne Black Bears | 25 | 03/14/2001 | Indianapolis | USA | Right | Left | 6' 1" | 205 lbs | - |
| Skipper, Carson | RP | Reading Roughnecks | 26 | 08/12/1999 | Unknown | USA | Left | Left | 6' 3" | 210 lbs | - |
| Smelley, Colby | C | Quebec Castors | 26 | 03/15/2000 | Tuscaloosa | USA | Right | Right | 6' 2" | 195 lbs | - |
| Solesky, Chase | SP | Quebec Castors | 28 | 09/26/1997 | Fort Pierce | USA | Right | Right | 6' 3" | 200 lbs | - |
| Solomon, Peter | RP | Dayton Dragons | 29 | 08/16/1996 | Unknown | USA | Right | Right | 6' 4" | 205 lbs | - |
| Sosa, Thomas | CF | Canton Cutters | 21 | 01/18/2005 | Mella | DOM | Left | Left | 6' 1" | 160 lbs | - |
| Southisene, Ty | SS | Trenton Thunder | 20 | 07/08/2005 | Henderson | USA | Right | Right | 5' 9" | 160 lbs | - |
| St. Laurent, Austin | 2B | London Wolverines | 23 | 07/13/2002 | Elon | USA | Right | Right | 5' 11" | 185 lbs | - |
| Stauffer, Adam | SP | Hempstead Flying Dutchmen | 27 | 01/13/1999 | Coatesville | USA | Right | Right | 6' 7" | 240 lbs | - |
| Stevens, Felix | LF | Reading Roughnecks | 26 | 07/30/1999 | Havana | CUB | Right | Right | 6' 4" | 235 lbs | - |
| Strowd, Kade | RP | Quebec Castors | 28 | 09/17/1997 | Fort Worth | USA | Right | Right | 6' 2" | 175 lbs | - |
| Suisbel, Luis | 3B | Reading Roughnecks | 22 | 05/23/2003 | Valencia | VEN | Switch | Right | 6' 1" | 190 lbs | - |
| Sullivan, Joseph | RF | Dayton Dragons | 23 | 07/01/2002 | Birmingham | USA | Left | Left | 5' 11" | 200 lbs | - |
| Sullivan, Sean | RP | Harrisburg Senators | 25 | 08/02/2000 | Woodland Hills | USA | Right | Right | 6' 1" | 175 lbs | - |
| Sundstrom, Jared | LF | Plattsburgh Beacons | 24 | 06/21/2001 | Santa Rosa | USA | Right | Right | 6' 3" | 225 lbs | - |
| Swan, Eriq | SP | London Wolverines | 24 | 10/31/2001 | Murfreesboro | USA | Right | Right | 6' 6" | 240 lbs | - |
| Szykowny, Charlie | 3B | Albany Ambassadors | 25 | 06/30/2000 | Colorado Springs | USA | Left | Right | 6' 4" | 225 lbs | - |
