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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saalfrank, Andrew | CL | Plattsburgh Beacons | 27 | 08/18/1997 | Monroeville | USA | Left | Left | 6' 3" | 205 lbs | - |
| Salazar, Cesar | C | Harrisburg Senators | 29 | 03/15/1996 | South Tucson | USA | Left | Right | 5' 9" | 185 lbs | - |
| Salinas, Royber | SP | London Wolverines | 24 | 04/10/2001 | Guarenas | VEN | Right | Right | 6' 3" | 205 lbs | - |
| Sanmartin, Reiver | SP | Quebec Castors | 29 | 04/15/1996 | Cartagena | COL | Left | Left | 6' 2" | 155 lbs | - |
| Santana, Luis | 2B | London Wolverines | 25 | 07/20/1999 | Baní | DOM | Right | Right | 5' 9" | 170 lbs | - |
| Sauer, Matt | SP | Quebec Castors | 26 | 01/21/1999 | Unknown | USA | Right | Right | 6' 4" | 200 lbs | - |
| Schulfer, Austin | RP | Champagne Black Bears | 29 | 12/22/1995 | Plover | USA | Right | Right | 6' 2" | 175 lbs | - |
| Schultz, Paxton | SP | Trenton Thunder | 27 | 01/05/1998 | Orem | USA | Left | Right | 6' 3" | 205 lbs | - |
| Sedlock, Cody | SP | Trenton Thunder | 30 | 06/19/1995 | Unknown | USA | Right | Right | 6' 4" | 215 lbs | - |
| Seise, Chris | SS | Albany Ambassadors | 26 | 01/06/1999 | Unknown | USA | Right | Right | 6' 2" | 180 lbs | - |
| Seminaris, Adam | SP | Dayton Dragons | 26 | 10/19/1998 | Pomona | USA | Right | Left | 6' 0" | 185 lbs | - |
| Senger, Hayden | C | Canton Cutters | 28 | 04/03/1997 | Virginia Beach | USA | Right | Right | 6' 1" | 210 lbs | - |
| Severino, Anderson | RP | Harrisburg Senators | 30 | 09/17/1994 | Unknown | DOM | Left | Left | 5' 10" | 165 lbs | - |
| Seymour, Carson | SP | London Wolverines | 26 | 12/16/1998 | Poway | USA | Right | Right | 6' 5" | 250 lbs | - |
| Seymour, Ian | SP | London Wolverines | 26 | 12/13/1998 | Unknown | USA | Left | Left | 6' 0" | 190 lbs | - |
| Shackelford, Aaron | 2B | Champagne Black Bears | 28 | 10/16/1996 | Murrieta | USA | Left | Right | 5' 10" | 205 lbs | - |
| Sharp, Jacob | C | Plattsburgh Beacons | 23 | 09/15/2001 | La Mirada | USA | Right | Right | 5' 11" | 195 lbs | - |
| Short, Avery | SP | Champagne Black Bears | 24 | 03/14/2001 | Indianapolis | USA | Right | Left | 6' 1" | 205 lbs | - |
| Shortridge, Aaron | SP | Plattsburgh Beacons | 28 | 05/29/1997 | Santa Rosa | USA | Right | Right | 6' 3" | 195 lbs | - |
| Sikes, Phillip | CF | Hempstead Flying Dutchmen | 26 | 04/27/1999 | Paris | USA | Right | Right | 6' 2" | 190 lbs | - |
| Skipper, Carson | RP | Reading Roughnecks | 25 | 08/12/1999 | Unknown | USA | Left | Left | 6' 3" | 210 lbs | - |
| Smeltzer, Devin | SP | Madison Millers | 29 | 09/07/1995 | Voorheesville | USA | Right | Left | 6' 3" | 190 lbs | - |
| Snider, Jake | 3B | Champagne Black Bears | 27 | 05/19/1998 | Champaign | USA | Left | Right | 6' 1" | 190 lbs | - |
| Solesky, Chase | SP | Quebec Castors | 27 | 09/26/1997 | Fort Pierce | USA | Right | Right | 6' 3" | 200 lbs | - |
| Sommers, Drew | RP | Hempstead Flying Dutchmen | 24 | 08/14/2000 | Unknown | USA | Left | Left | 6' 3" | 250 lbs | - |
| Song, Noah | SP | Canton Cutters | 28 | 05/28/1997 | Claremont | USA | Right | Right | 6' 4" | 200 lbs | - |
| Sproat, Brandon | SP | Canton Cutters | 24 | 09/17/2000 | Pace | USA | Right | Right | 6' 3" | 215 lbs | - |
| Squires, Brett | 1B | Hempstead Flying Dutchmen | 25 | 02/26/2000 | Grapevine | USA | Left | Right | 6' 3" | 205 lbs | - |
| Stallings, Garrett | RP | Canton Cutters | 27 | 08/08/1997 | Chesapeake | USA | Right | Right | 6' 2" | 200 lbs | - |
| Stauffer, Adam | SP | Hempstead Flying Dutchmen | 26 | 01/13/1999 | Coatesville | USA | Right | Right | 6' 7" | 240 lbs | - |
| Stevens, Felix | LF | Reading Roughnecks | 25 | 07/30/1999 | Havana | CUB | Right | Right | 6' 4" | 235 lbs | - |
| Strowd, Kade | RP | Quebec Castors | 27 | 09/17/1997 | Fort Worth | USA | Right | Right | 6' 2" | 175 lbs | - |
| Suarez, Andrew | SP | London Wolverines | 32 | 09/11/1992 | Unknown | USA | Left | Left | 6' 2" | 210 lbs | - |
| Suarez, Jose | SP | Dayton Dragons | 27 | 01/03/1998 | Unknown | VEN | Left | Left | 5' 10" | 175 lbs | - |
| Susac, Daniel | C | Canton Cutters | 24 | 05/14/2001 | Unknown | USA | Switch | Right | 6' 4" | 205 lbs | - |
