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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sabol, Blake | LF | Fresno Grizzlies | 28 | 01/07/1998 | Aliso Viejo | USA | Left | Right | 6' 4" | 215 lbs | - |
| Sanchez, Yosber | RP | Roswell UFO | 25 | 05/22/2001 | Unknown | DOM | Right | Right | 6' 1" | 170 lbs | - |
| Santa, Alimber | SP | Tempe Titans | 23 | 05/03/2003 | Azua | DOM | Right | Right | 5' 10" | 165 lbs | - |
| Santana, Cristian | 3B | Fresno Grizzlies | 29 | 02/24/1997 | San Cristóbal | DOM | Right | Right | 6' 2" | 185 lbs | - |
| Santiago, Glenn | SS | Tulsa T-Bones | 25 | 12/14/2000 | Guanica | PUR | Right | Right | 6' 0" | 165 lbs | - |
| Santos, Victor | SP | Tulsa T-Bones | 26 | 07/12/2000 | Villa Tapia | DOM | Right | Right | 6' 1" | 190 lbs | - |
| Sasaki, Shane | CF | Roswell UFO | 26 | 07/01/2000 | Mililani Town | USA | Right | Right | 6' 0" | 165 lbs | - |
| Schneemann, Daniel | 3B | Roswell UFO | 29 | 01/23/1997 | Chula Vista | USA | Left | Right | 6' 1" | 185 lbs | - |
| Schofield-Sam, T.J. | 3B | Plano-Frisco Roughriders | 25 | 06/20/2001 | Unknown | CAN | Left | Right | 6' 1" | 185 lbs | - |
| Seelinger, Matt | RP | Midland Rattlers | 31 | 04/19/1995 | Westbury | USA | Right | Right | 6' 3" | 190 lbs | - |
| Serwinowski, Adam | SP | Plano-Frisco Roughriders | 22 | 06/07/2004 | Unknown | USA | Left | Left | 6' 5" | 190 lbs | - |
| Silseth, Chase | SP | Amarillo Armadillos | 26 | 05/18/2000 | Farmington | USA | Right | Right | 6' 0" | 215 lbs | - |
| Simas, Karson | 3B | Fresno Grizzlies | 25 | 06/02/2001 | Fresno | USA | Right | Right | 6' 6" | 175 lbs | - |
| Smith, Dominic | 1B | Plano-Frisco Roughriders | 31 | 06/15/1995 | Los Angeles | USA | Left | Left | 6' 1" | 205 lbs | - |
| Smith, Drew | RP | Midland Rattlers | 32 | 09/24/1993 | Unknown | USA | Right | Right | 6' 2" | 195 lbs | - |
| Smith, Hagen | SP | Amarillo Armadillos | 22 | 08/19/2003 | Bullard | USA | Left | Left | 6' 3" | 215 lbs | - |
| Snyder, Michael | 3B | Amarillo Armadillos | 25 | 09/16/2000 | Los Angeles | USA | Right | Right | 6' 4" | 225 lbs | - |
| Speas, Alex | RP | Fresno Grizzlies | 28 | 03/04/1998 | Powder Springs | USA | Right | Right | 6' 4" | 195 lbs | - |
| Spiers, Carson | SP | Fresno Grizzlies | 28 | 11/11/1997 | Unknown | USA | Right | Right | 6' 3" | 205 lbs | - |
| Spikes, Ryan | 3B | San Jose Thorns | 23 | 03/13/2003 | Conyers | USA | Right | Right | 5' 9" | 185 lbs | - |
| Stashak, Cody | RP | Roswell UFO | 32 | 06/04/1994 | Unknown | USA | Right | Right | 6' 2" | 195 lbs | - |
| Stephan, Josh | SP | Midland Rattlers | 24 | 11/01/2001 | Grand Prairie | USA | Right | Right | 6' 3" | 185 lbs | - |
| Swanson, Erik | RP | Plano-Frisco Roughriders | 32 | 09/04/1993 | Unknown | USA | Right | Right | 6' 3" | 230 lbs | - |
| Sykora, Travis | SP | Tulsa T-Bones | 22 | 04/28/2004 | Round Rock | USA | Right | Right | 6' 6" | 220 lbs | - |
