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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saenz, Dustin | RP | Danville Raiders | 25 | 06/02/1999 | Corpus Christi | USA | Left | Left | 5' 11" | 190 lbs | - |
| Samaniego, Tyler | RP | Brunswick Pilots | 26 | 01/30/1999 | Huntsville | USA | Right | Left | 6' 4" | 205 lbs | - |
| Sanabria, Romeo | 1B | Newport News Destroyers | 22 | 05/02/2002 | Unknown | USA | Left | Right | 6' 2" | 200 lbs | - |
| Sanchez, Yolbert | SS | Prince William Panthers | 28 | 03/03/1997 | Havana | CUB | Right | Right | 5' 11" | 175 lbs | - |
| Sanders, Cam | RP | Kingston Buccaneers | 28 | 12/09/1996 | Thibodaux | USA | Right | Right | 6' 2" | 175 lbs | - |
| Sanoja, Javier | 2B | Kingston Buccaneers | 22 | 09/03/2002 | Maracay | VEN | Right | Right | 5' 9" | 150 lbs | - |
| Santa, Alimber | SP | Winston-Salem Smokers | 21 | 05/03/2003 | Azua | DOM | Right | Right | 5' 10" | 165 lbs | - |
| Santana, Leandro | 1B | Winston-Salem Smokers | 28 | 02/19/1997 | Santo Domingo | DOM | Right | Right | 6' 2" | 185 lbs | - |
| Santos, Junior | RP | Easton Grays | 23 | 08/16/2001 | Santiago | DOM | Right | Right | 6' 8" | 220 lbs | - |
| Scherff, Alex | RP | Brunswick Pilots | 27 | 02/05/1998 | Unknown | USA | Switch | Right | 6' 3" | 210 lbs | - |
| Schreffler, Troy | LF | Brunswick Pilots | 24 | 10/27/2000 | Unknown | USA | Right | Right | 6' 1" | 190 lbs | - |
| Seig, Hayden | RP | Kingston Buccaneers | 26 | 09/10/1998 | Mechanicsburg | USA | Right | Right | 6' 5" | 225 lbs | - |
| Sepulveda, Carlos | 2B | Kingston Buccaneers | 28 | 08/27/1996 | Monclova | MEX | Left | Right | 5' 10" | 175 lbs | - |
| Serretti, Danny | SS | Prince William Panthers | 24 | 05/07/2000 | Mound City | USA | Switch | Right | 6' 0" | 185 lbs | - |
| Severino, Jhonny | 3B | Newport News Destroyers | 20 | 11/08/2004 | Santo Domingo | DOM | Right | Right | 6' 3" | 185 lbs | - |
| Shaver, Colton | C | Alexandria Dukes | 29 | 09/18/1995 | Unknown | USA | Right | Right | 6' 1" | 210 lbs | - |
| Sisneros, Cameron | 1B | Winston-Salem Smokers | 23 | 06/01/2001 | Littleton | USA | Left | Left | 6' 2" | 230 lbs | - |
| Smelley, Colby | C | Alexandria Dukes | 25 | 03/15/2000 | Tuscaloosa | USA | Right | Right | 6' 2" | 195 lbs | - |
| Smith, Austin | SP | Wilmington Blue Rocks | 25 | 06/22/1999 | Cedar Park | USA | Right | Right | 6' 3" | 200 lbs | - |
| Sommer, Tommy | SP | Alexandria Dukes | 26 | 09/25/1998 | Carmel | USA | Left | Left | 6' 4" | 220 lbs | - |
| Soriano, George | SP | Alexandria Dukes | 26 | 03/24/1999 | San Pedro de Macorís | DOM | Right | Right | 6' 2" | 170 lbs | - |
| Sosa, Thomas | CF | Easton Grays | 20 | 01/18/2005 | Mella | DOM | Left | Left | 6' 1" | 160 lbs | - |
| Spain, Dylan | SP | Wilmington Blue Rocks | 26 | 06/21/1998 | Honolulu | USA | Right | Right | 6' 6" | 205 lbs | - |
| Sprague, Shea | SP | Wilmington Blue Rocks | 22 | 01/03/2003 | Hanover | USA | Right | Left | 6' 3" | 185 lbs | - |
| St. Laurent, Austin | 2B | Lynchburg Scouts | 22 | 07/13/2002 | Elon | USA | Right | Right | 5' 11" | 185 lbs | - |
| Stambaugh, Dalton | SP | Alexandria Dukes | 28 | 02/11/1997 | Morehead | USA | Right | Left | 6' 0" | 195 lbs | - |
| Steward, Casey | RP | Wilmington Blue Rocks | 23 | 08/02/2001 | Wichita | USA | Right | Right | 6' 5" | 260 lbs | - |
| Swan, Eriq | SP | Lynchburg Scouts | 23 | 10/31/2001 | Murfreesboro | USA | Right | Right | 6' 6" | 240 lbs | - |
| Swiney, Nick | RP | Brunswick Pilots | 26 | 02/12/1999 | Nashville | USA | Right | Left | 6' 3" | 185 lbs | - |
